Results 91 to 100 of about 37,576 (262)

Probucol Inhibits ABCA1-Mediated Cellular Lipid Efflux [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2004
Objective— ATP-binding cassette transporter A1 (ABCA1) mediates the efflux of lipids from cells to lipid-poor apolipoproteins. In this article, we characterize the effect of probucol on cellular ABCA1-mediated lipid efflux. Methods and Results—
FAVARI, Elda, ZANOTTI, Ilaria, ZIMETTI, Francesca, RONDA, Nicoletta, BERNINI, Franco, ROTHBLAT G. H.   +5 more
openaire   +3 more sources

MP Allosterically Activates AMPK to Enhance ABCA1 Stability by Retarding the Calpain-Mediated Degradation Pathway [PDF]

, 2023
Hui Li, Mingchao Wang, Kai Qu, Rui-Ming Xu, Haibo Zhu   +4 more
openalex   +1 more source

The ATP-binding cassette transporter 1 mediates lipid efflux from Sertoli cells and influences male fertility

Journal of Lipid Research, 2004
The liver X receptor/retinoid X receptor (LXR/RXR)-regulated gene ABCA1 effluxes cellular cholesterol and phospholipid to apolipoprotein A1 (apoA1), which is the rate-limiting step in high-density lipoprotein synthesis.
David M. Selva, Veronica Hirsch-Reinshagen, Braydon Burgess, Steven Zhou, Jeniffer Chan, Sean McIsaac, Michael R. Hayden, Geoffrey L. Hammond, A. Wayne Vogl, Cheryl L. Wellington   +9 more
doaj   +1 more source

Role of ATP-binding cassette transporter A1 in suppressing lipid accumulation by glucagon-like peptide-1 agonist in hepatocytes

Molecular Metabolism, 2020
Objective: Adenosine triphosphate (ATP)-binding cassette transporter A1 (ABCA1) influences hepatic cholesterol transportation. Accumulation of hepatic cholesterol leads to fatty liver disease, which is improved by glucagon-like peptide 1 (GLP-1) in ...
Jingya Lyu, Hitomi Imachi, Kensaku Fukunaga, Seisuke Sato, Toshihiro Kobayashi, Tao Dong, Takanobu Saheki, Mari Matsumoto, Hisakazu Iwama, Huanxiang Zhang, Koji Murao   +10 more
doaj   +1 more source

Oat β‐Glucan and Galactooligosaccharides Influence Gallstone Formation by Modulating the Gut Microbiota, Particularly Desulfovibrionales

iMetaMed, EarlyView.
Oat β‐glucan and galactooligosaccharides influence the formation of gallstones by modulating the gut microbiota, particularly the abundance of Desulfovibrionales. The primary mechanism involves metabolic byproducts associated with Desulfovibrionales inhibiting hepatic bile acid synthesis via both the hepatic FXR–SHP and intestinal FXR–FGF15 signaling ...
Liang Tian, Yanyan Lin, Ping Yue, Long Gao, Leiqing Wang, Chongfei Huang, Jinyu Zhao, Ningzu Jiang, Jiahui xi, Haidong Ma, Zhen Liu, Ruyang Zhong, Wenkang Fu, Ningning Mi, Mingzhen Bai, Bodong Zhang, Lunzhi Dai, Jiang Li, Hu Chen, Jinqiu Yuan, Wenbo Meng   +20 more
wiley   +1 more source

Both STAT3 activation and cholesterol efflux contribute to the anti-inflammatory effect of apoA-I/ABCA1 interaction in macrophages

Journal of Lipid Research, 2016
ABCA1 exports excess cholesterol from cells to apoA-I and is essential for HDL synthesis. Genetic studies have shown that ABCA1 protects against cardiovascular disease.
Chongren Tang, Barbara A. Houston, Carl Storey, Renee C. LeBoeuf   +3 more
doaj   +1 more source

The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches

Medicinal Research Reviews, EarlyView.
ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi, Theodora Katavati, Angeliki P. Kourounakis   +2 more
wiley   +1 more source

Chronic hyperplastic anemia as an independent risk factor for atherosclerotic lesions: a lesson from thalassemia intermedia [PDF]

, 2010
Introduction. Cardiovascular involvement represents a well-known complication and the primary cause of mortality, both in transfusion-dependent beta thalassemia major (β-TM) and in transfusion-independent beta thalassemia intermedia (β-TI ...
Alessandra Spiga, Antonella Mandas, Fabrizio Angius, Maria Eliana Lai, Maria Paola Carta, Pier Luigi Cocco, Sandra Dessi, Stefania Vacquer   +7 more
core   +1 more source

The E-box motif in the proximal ABCA1 promoter mediates transcriptional repression of the ABCA1 gene [PDF]

Journal of Lipid Research, 2002
To identify regulatory elements in the proximal human ATP-binding cassette transporter A1 (hABCA1) gene promoter we transfected RAW cells with plasmids containing mutations in the E-box, AP1, and liver X receptor (LXR) elements as well as the two Sp1 motifs.
Xiao-Ping Yang, Lita A. Freeman, Catherine L. Knapper, Marcelo J.A. Amar, Alan Remaley, H. Bryan Brewer, Jr., Silvia Santamarina-Fojo   +6 more
openaire   +3 more sources

The Dietary Constituent Falcarindiol Promotes Cholesterol Efflux from THP-1 Macrophages by Increasing ABCA1 Gene Transcription and Protein Stability

Frontiers in Pharmacology, 2017
We report increased cholesterol efflux from macrophages in the presence of falcarindiol, an important dietary constituent present in commonly used vegetables and medicinal plants.
Limei Wang, Limei Wang, Veronika Palme, Nicole Schilcher, Angela Ladurner, Elke H. Heiss, Herbert Stangl, Rudolf Bauer, Verena M. Dirsch, Atanas G. Atanasov, Atanas G. Atanasov   +10 more
doaj   +1 more source