ABCA1 influences neuroinflammation and neuronal death
Neurobiology of Disease, 2013 ATP-binding cassette transporter A1 (ABCA1) mediates cellular cholesterol efflux in the brain and influences whole brain cholesterol homeostasis. Activation of liver X receptors (LXRs), transcription factors that increase the expression of cholesterol ...
Joanna M. Karasinska +10 more
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Origins of intestinal ABCA1-mediated HDL-cholesterol* [PDF]
Journal of Lipid Research, 2008 The origins of cholesterol utilized by intestinal ABCA1 were investigated in the human intestinal cell line Caco-2. Influx of apical membrane cholesterol increases ABCA1 mRNA and mass, resulting in enhanced efflux of HDL-cholesterol.
F. Jeffrey Field +2 more
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Model system for the analysis of cell surface expression of human ABCA1 [PDF]
BMC Cell Biology, 2009 Background The ABCA1 protein plays a pivotal role in reverse cholesterol transport, by mediating the generation of HDL particles and removing cellular cholesterol.
Sarkadi Balázs +7 more
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Angiotensin II induces cholesterol accumulation and impairs insulin secretion by regulating ABCA1 in beta cells [PDF]
Journal of Lipid Research, 2018 In pancreatic β cells, ABCA1, a 254 kDa membrane protein, affects cholesterol homeostasis and insulin secretion. Angiotensin II, as the main effector of the renin–angiotensin system, decreases glucose-stimulated insulin secretion (GSIS).
Jingya Lyu +11 more
doaj +2 more sources
The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease. [PDF]
, 2005 J Biol Chem. 2005 Dec 30;280(52):43243-56. Epub 2005 Oct 5. The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease.
BLAIN, J.F. +12 more
core +4 more sources
Neural Regeneration Research, 2023 Alzheimer’s disease, the primary cause of dementia, is characterized by neuropathologies, such as amyloid plaques, synaptic and neuronal degeneration, and neurofibrillary tangles.
Beibei Wu +6 more
doaj +1 more source
Role of high-density lipoprotein cholesterol in health and diseases
Indian Journal of Rheumatology, 2021 Primary function of high-density lipoprotein cholesterol is to reverse transport the cholesterol from extrahepatic cell to liver for its metabolism and excretion.
Brijesh Yadav, Narayan Prasad
doaj +1 more source
Differences between the Molecular Mechanisms Underlying Ruptured and Non-Ruptured Carotid Plaques, and the Significance of ABCA1 [PDF]
Journal of Stroke, 2018 Background and Purpose Carotid plaques are a strong risk factor for ischemic stroke, and plaque rupture poses an even higher risk. Although many studies have investigated the pathogenic mechanisms of carotid plaque formation, few have studied the ...
Sung Hyuk Heo +8 more
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ABCA1 có thể đích tiềm năng của miRNA-144 trong tế bào sụn
Tạp chí Khoa học Đại học Mở Thành phố Hồ Chí Minh - Kỹ thuật và Công nghệ, 2022 MiR-144-3p trước đây được chứng minh là có vai trò quan trọng trong sinh học sụn, với các tác động tiềm ẩn trong thoái hóa khớp (OA). Một cái nhìn sâu sắc về chức năng của miRNA này có thể có tầm quan trọng thực tế đối với liệu pháp điều trị dựa trên ...
Mai Thị Cẩm Ngân +1 more
doaj +1 more source
Evaluating correlation between the ocular biometry and genetic variants of MYOC and ABCA1 with primary angle-closure glaucoma in a cohort from northern China [PDF]
International Journal of Ophthalmology, 2019 AIM: To investigate whether the gene variants in MYOC and ABCA1 are associated with primary angle-closure glaucoma (PACG) and anterior chamber depth (ACD) and axial length (AL) in samples from northern China.
Shao-Lin Wang +9 more
doaj +1 more source