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Association of ATP-Binding Cassette Transporter A1 (ABCA1)-565 C/T Gene Polymorphism with Hypoalphalipoproteinemia and Serum Lipids, IL-6 and CRP Levels.

, 2017
Babashamsi Mohammad Mahdi, Sohrab Halalkhor, Moradi Firouzjah Hamid, Hadi Parsian, Farzad Jalali, Mohammad Babashamsi   +5 more
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ABCA1, ABCG1, and Cholesterol Homeostasis

2022
Cholesterol is a major component of mammalian cell membranes and plays important structural and functional roles. However, excessive cholesterol accumulation is toxic to cells and constitutes the molecular basis for many diseases, especially atherosclerotic cardiovascular disease.
Xiao-Hua, Yu, Chao-Ke, Tang
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Calpain-mediated ABCA1 degradation: Post-translational regulation of ABCA1 for HDL biogenesis

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2012
Helical apolipoproteins remove cellular phospholipid and cholesterol to generate nascent HDL and this reaction is the major source of plasma HDL. ABCA1 is mandatory and rate-limiting for this reaction. Besides regulation of the gene expression by transcriptional factors including LXR, AP2 and SREBP, the ABCA1 activity is regulated post-translationally ...
Shinji, Yokoyama, Reijiro, Arakawa, Cheng-Ai, Wu, Noriyuki, Iwamoto, Rui, Lu, Maki, Tsujita, Sumiko, Abe-Dohmae   +6 more
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Serum Amyloid a promotes ABCA1-dependent and ABCA1-independent lipid efflux from cells

Biochemical and Biophysical Research Communications, 2004
Serum amyloid A (SAA) is an acute phase protein that associates with HDL. In order to examine the role of SAA in reverse-cholesterol transport, lipid efflux was tested to SAA from HeLa cells before and after transfection with the ABCA1 transporter.
John A, Stonik, Alan T, Remaley, Steve J, Demosky, Edward B, Neufeld, Alexander, Bocharov, H Bryan, Brewer   +5 more
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Tangier disease and ABCA1

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2000
Tangier disease is an autosomal recessive genetic disorder characterized by a severe high-density lipoprotein (HDL) deficiency, sterol deposition in tissue macrophages, and prevalent atherosclerosis. Mutations in the ATP binding cassette transporter ABCA1 cause Tangier disease and other familial HDL deficiencies.
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Molecular mechanisms for ABCA1-mediated cholesterol efflux

Cell Cycle, 2022
The maintenance of cellular cholesterol homeostasis is essential for normal cell function and viability. Excessive cholesterol accumulation is detrimental to cells and serves as the molecular basis of many diseases, such as atherosclerosis, Alzheimer's disease, and diabetes mellitus.
Lei, Chen, Zhen-Wang, Zhao, Peng-Hui, Zeng, Ying-Jie, Zhou, Wen-Jun, Yin   +4 more
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History and Development of ABCA1

Current Problems in Cardiology
ATP-binding cassette protein A1 (ABCA1) is a key protein in the transport of intracellular cholesterol to the extracellular and plays an important role in reducing cholesterol accumulation in surrounding tissues. Bibliometric analysis refers to the cross-science of quantitative analysis of a variety of documents by mathematical and statistical methods.
Yang Wang, Min Guo, Chao-Ke Tang
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New insights into cholesterol efflux via ABCA1

Nature Cardiovascular Research, 2022
ABCA1 promotes the efflux of cholesterol from cells to HDL and has anti-atherogenic activities. Sun and Li present cryo-EM structures of ABCA1 in the ATP-free and ATP-bound states, which reveal bound cholesterol molecules and suggest a transmembrane cholesterol-transport mechanism.
Alan R. Tall, Nan Wang
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