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2012 International Conference on Biomedical Engineering and Biotechnology, 2012
In this study we explored that whether PDE inhibitor rolipram affected cholesrterol efflux and ABCA1 expression in THP-1 macrophage foam cells. Cholesterol efflux in THP-1 macrophage-derived foam cells were detected by FJ-2107P type liquid scintillator. The expression of ABCA1 mRNA and protein were determined by RT-PCR and Western blotting respectively.
Ping-Ping He +8 more
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In this study we explored that whether PDE inhibitor rolipram affected cholesrterol efflux and ABCA1 expression in THP-1 macrophage foam cells. Cholesterol efflux in THP-1 macrophage-derived foam cells were detected by FJ-2107P type liquid scintillator. The expression of ABCA1 mRNA and protein were determined by RT-PCR and Western blotting respectively.
Ping-Ping He +8 more
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Placenta, 2013
Transplacental feto-maternal lipid exchange through the ATP-binding cassette transporters ABCA1 and ABCG1 is important for normal fetal development. However, only scarce and conflicting data exist on the involvement of these transporters in gestational disease.Placenta samples (n = 72) derived from common gestational diseases, including pre-eclampsia ...
Baumann M +5 more
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Transplacental feto-maternal lipid exchange through the ATP-binding cassette transporters ABCA1 and ABCG1 is important for normal fetal development. However, only scarce and conflicting data exist on the involvement of these transporters in gestational disease.Placenta samples (n = 72) derived from common gestational diseases, including pre-eclampsia ...
Baumann M +5 more
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PPARγ activates ABCA1 gene transcription but reduces the level of ABCA1 protein in HepG2 cells
Biochemical and Biophysical Research Communications, 2010Synthesis of ABCA1 protein in liver is necessary for high-density lipoproteins (HDL) formation in mammals. Nuclear receptor PPARγ is known as activator of ABCA1 expression, but details of PPARγ-mediated regulation of ABCA1 at both transcriptional and post-transcriptional levels in hepatocytes have not still been well elucidated.
Denis A, Mogilenko +4 more
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The COP9 signalosome controls ubiquitinylation of ABCA1
Biochemical and Biophysical Research Communications, 2009ATP-binding cassette protein A1 (ABCA1) mediates the transfer of cellular free cholesterol and phospholipids to apolipoprotein A-I (apoA-I), an extracellular acceptor in plasma, to form high-density lipoprotein (HDL). ABCA1 has been suggested to be degraded by proteasome in cholesterol-loaded macrophages, however, the mechanism and regulation of ...
Yuya, Azuma +4 more
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ABCA1 and the engulfment of apoptotic cells
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2002Programmed cell death is one of the major devices controlling cellular homeostasis. However, the generation of cell debris that follows the execution phase of apoptosis has to be backed up by their efficient removal by phagocyte. This highly dynamic process requires the concerted action of a number of surface molecules able to recognize early signals ...
Yannick, Hamon +2 more
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Phospholipid transporters ABCA1 and ABCA7
2003So far, a total of 12 genes have been assigned to the ABCA subclass of ABC tran sporters (Dean et al. 2001). The complete human coding regions and genomic structures have been determined for seven transporters of this subfamily. In addition to the prototypic members ABCA1 (Langman et al. 1999) and ABCA2 (Kaminski et al.
Gerd Schmitz, Wolfgang E. Kaminski
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