Advanced Biomedical Research, 2023 Background: Elevated brain cholesterol increases the risk of Alzheimer's disease. Production of 24-hydroxycholesterol (24s-OHC) by neurons prevents cholesterol accumulation in the brain. In this study, we investigated the effect of 24s-OHC on the HMG-COA
Zahra Nazeri +5 more
doaj +1 more source
Exosomes containing HIV protein Nef reorganize lipid rafts potentiating inflammatory response in bystander cells. [PDF]
, 2019 HIV infection has a profound effect on "bystander" cells causing metabolic co-morbidities. This may be mediated by exosomes secreted by HIV-infected cells and containing viral factors.
Brichacek, Beda +15 more
core +3 more sources
Arteriosclerosis, Thrombosis, and Vascular Biology, 2015 ATP-binding cassette transporter subfamily A member 1 (ABCA1) is a plasma membrane protein well known for its role in regulating cellular cholesterol efflux and high-density lipoprotein (HDL) formation.1 Carriers of loss-of-function mutations in ABCA1 are characterized by reduced HDL cholesterol levels, which are nearly absent in the rare homozygous ...
Xin, Bi, Cecilia, Vitali, Marina, Cuchel
openaire +2 more sources
Effects of Combined aerobic and resistance Exercise on miR-93, Reverse Cholesterol Transport and Serum Leptin Levels in Patients After Coronary Artery Bypass Graft Surgery [PDF]
Journal of Mazandaran University of Medical Sciences, 2023 Background and purpose: Cardiovascular diseases (CVDs) are the leading cause of death worldwide that account for 82% of all deaths in developing countries.
Fahime Sadat Jamali +2 more
doaj
Genetic obesity increases pancreatic expression of mitochondrial proteins which regulate cholesterol efflux in BRIN-BD11 insulinoma cells [PDF]
, 2019 Pancreatic β-cells are sensitive to fluctuations in cholesterol content, which can damage the insulin secretion pathway, contributing to the aetiology of type 2 diabetes mellitus.
Caridis, Anna Maria +4 more
core +1 more source
Vascular Medicine, 2005 ATP binding cassette transporter A1 (ABCA1) mediates the cellular efflux of phospholipids and cholesterol to lipid-poor apolipoprotein A1 (apoA1) and plays a significant role in high density lipoprotein (HDL) metabolism. ABCA1’s role in the causation of Tangier disease, characterized by absent HDL and premature atherosclerosis, has implicated this ...
Soumian, S +3 more
openaire +2 more sources
ABCA1 is an extracellular phospholipid translocase
Nature Communications, 2022 AbstractProduction of high density lipoprotein (HDL) requires ATP-binding cassette transporter A1 (ABCA1) to drive phospholipid (PL) from the plasma membrane into extracellular apolipoprotein A-I. Here, we use simulations to show that domains of ABCA1 within the plasma membrane remove PL from the membrane’s outer leaflet.
Jere P. Segrest +6 more
openaire +3 more sources
Tissue-specific regulation of sirtuin and nicotinamide adenine dinucleotide biosynthetic pathways identified in C57Bl/6 mice in response to high-fat feeding [PDF]
, 2016 Funding: The Scottish Government's Rural and Environment Science and Analytical Services Division.Peer ...
Drew, Janice E. +3 more
core +1 more source
Effect of a novel nutraceutical combination on serum lipoprotein functional profile and circulating PCSK9 [PDF]
, 2017 BACKGROUND: A beneficial effect on cardiovascular risk may be obtained by improving lipid-related serum lipoprotein functions such as high-density lipoproteins (HDLs) cholesterol efflux capacity (CEC) and serum cholesterol loading capacity (CLC) and by ...
Adorni, Maria Pia +7 more
core +3 more sources
The ٍeffect of Eight Weeks of Moderate and High Intensity Resistance Training on micro-RNAs Associated with Reverse Cholesterol Transport in Older Wistar rats [PDF]
فیزیولوژی ورزش و فعالیت بدنی, 2019 Purpose: Aging is associated with systemic dysfunctions in lipid metabolism and chronic inflammatory state which contribute to atherosclerotic. The purpose of this study was to investigate the effect of moderate and high intensity resistance training on ...
mehdi taheri gandomany +3 more
doaj +1 more source