PPARγ and LXR Signaling Inhibit Dendritic Cell-Mediated HIV-1 Capture and trans-Infection [PDF]
, 2010 Dendritic cells (DCs) contribute to human immunodeficiency virus type 1 (HIV-1) transmission and dissemination by capturing and transporting infectious virus from the mucosa to draining lymph nodes, and transferring these virus particles to CD4+ T cells ...
Blay Puryear, Wendy +3 more
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OSBP Negatively Regulates ABCA1 Protein Stability [PDF]
Journal of Biological Chemistry, 2008 Oxysterol binding to liver X receptors (LXR) increases the transcription of genes involved in cholesterol efflux and disposal, such as ABCA1 (ATP-binding cassette transporter A1). Other cytoplasmic sterol-binding proteins could interact with this pathway by sequestering or delivering substrates and ligands.
Kristin, Bowden, Neale D, Ridgway
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Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP in macrophages. [PDF]
, 2018 Activation of liver X receptors (LXRs) with synthetic agonists promotes reverse cholesterol transport and protects against atherosclerosis in mouse models.
Bahadorani, John +16 more
core +1 more source
Hepatocyte ABCA1 deficiency is associated with reduced HDL sphingolipids
Frontiers in Physiology, 2023 ATP binding cassette transporter A1 (ABCA1) limits the formation of high density lipoproteins (HDL) as genetic loss of ABCA1 function causes virtual HDL deficiency in patients with Tangier disease.
Alaa Othman +8 more
doaj +1 more source
High Density Lipoproteins Inhibit Oxidative Stress-Induced Prostate Cancer Cell Proliferation [PDF]
, 2018 Recent evidence suggests that oxidative stress can play a role in the pathogenesis and the progression of prostate cancer (PCa). Reactive oxygen species (ROS) generation is higher in PCa cells compared to normal prostate epithelial cells and this ...
Botta, Margherita +8 more
core +2 more sources
ABCA1, from pathology to membrane function [PDF]
Pflügers Archiv - European Journal of Physiology, 2006 The ABCA1 transporter is the prototype of the A class of mammalian adenosine triphosphate binding cassette transporters and one of the largest members of this family. ABCA1 has been originally identified as an engulfment receptor on macrophages and, more recently, it has been shown to play an essential role in the handling of cellular lipids. Indeed by
Zarubica, Ana +2 more
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Increased ABCA1 activity protects against atherosclerosis [PDF]
Journal of Clinical Investigation, 2002 The ABC transporter ABCA1 plays a key role in the first steps of the reverse cholesterol transport pathway by mediating lipid efflux from macrophages. Previously, it was demonstrated that human ABCA1 overexpression in vivo in transgenic mice results in a mild elevation of plasma HDL levels and increased efflux of cholesterol from macrophages.
Roshni R, Singaraja +11 more
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Diets containing sea cucumber (Isostichopus badionotus) meals are hypocholesterolemic in young rats [PDF]
, 2013 Peer reviewedPublisher ...
A Venkateswaran +72 more
core +8 more sources
Discover Oncology, 2023 Purpose ATP-binding cassette A1 (ABCA1) is a potential prognostic marker for various tumor types. However, the biological effects and prognostic value of ABCA1 in gastric adenocarcinoma (GAC) remain unknown.
Kaiyu Shen +3 more
doaj +1 more source
The liver X receptor pathway is highly upregulated in rheumatoid arthritis synovial macrophages and potentiates TLR-driven cytokine release [PDF]
, 2013 <p>Objectives: Macrophages are central to the inflammatory processes driving rheumatoid arthritis (RA) synovitis. The molecular pathways that are induced in synovial macrophages and thereby promote RA disease pathology remain poorly understood.</
Ananth +42 more
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