Results 51 to 60 of about 37,576 (262)

α1-Syntrophin Modulates Turnover of ABCA1 [PDF]

Journal of Biological Chemistry, 2004
ABCA1 (ATP-binding cassette transporter A1) mediates the release of cellular cholesterol and phospholipid to form high density lipoprotein. Functions of ABCA1 are highly regulated at the transcriptional and post-transcriptional levels, and the synthesized ABCA1 protein turns over rapidly with a half-life of 1-2 h.
Youichi, Munehira, Tomohiro, Ohnishi, Shinobu, Kawamoto, Akiko, Furuya, Kenya, Shitara, Michihiro, Imamura, Toshifumi, Yokota, Shin'ichi, Takeda, Teruo, Amachi, Michinori, Matsuo, Noriyuki, Kioka, Kazumitsu, Ueda   +11 more
openaire   +2 more sources

Histone Methyltransferase Enhancer of Zeste Homolog 2-Mediated ABCA1 Promoter DNA Methylation Contributes to the Progression of Atherosclerosis. [PDF]

PLoS ONE, 2016
ATP-binding cassette transporter A1 (ABCA1) plays a critical role in maintaining cellular cholesterol homeostasis. The purpose of this study is to identify the molecular mechanism(s) underlying ABCA1 epigenetic modification and determine its potential ...
Yun-Cheng Lv, Yan-Yan Tang, Ping Zhang, Wei Wan, Feng Yao, Ping-Ping He, Wei Xie, Zhong-Cheng Mo, Jin-Feng Shi, Jian-Feng Wu, Juan Peng, Dan Liu, Francisco S Cayabyab, Xi-Long Zheng, Xiang-Yang Tang, Xin-Ping Ouyang, Chao-Ke Tang   +16 more
doaj   +1 more source

ABCA1 Expression in Carotid Atherosclerotic Plaques [PDF]

Stroke, 2004
Background and Purpose— The ATP-binding cassette transporter A1 (ABCA1) facilitates cholesterol efflux from cells, a key process in reverse cholesterol transport. Whereas previous investigations focused on mutations causing impaired ABCA1 function, we assessed the role of ABCA1 in human carotid ...
C, Albrecht, S, Soumian, J S, Amey, A, Sardini, C F, Higgins, A H, Davies, R G J, Gibbs   +6 more
openaire   +2 more sources

The R219K polymorphism of the ATP binding cassette subfamily A member 1 gene and susceptibility to ischemic stroke in Chinese population

Open Medicine, 2020
Stroke is the major cause of death and disability worldwide. ABCA1 R219K has been suggested as a risk factor for ischemic stroke, but the results remain inconclusive in the Chinese population.
Li Jianmin, Wen Ming, Zhang Zhiping, Qiu Zhihua, Sun Yiming   +4 more
doaj   +1 more source

The secondary structure of apolipoprotein A-I on 9.6-nm reconstituted high-density lipoprotein determined by EPR spectroscopy. [PDF]

, 2013
Apolipoprotein A-I (ApoA-I) is the major protein component of high-density lipoprotein (HDL), and is critical for maintenance of cholesterol homeostasis.
Borja, Mark S, Budamagunta, Madhu S, Lagerstedt, Jens O, Oda, Michael N, Petrlova, Jitka, Voss, John C   +5 more
core   +1 more source

Ursolic acid enhances macrophage autophagy and attenuates atherogenesis [PDF]

, 2016
Macrophage autophagy has been shown to be protective against atherosclerosis. We previously discovered that ursolic acid (UA) promoted cancer cell autophagy.
Fan, Daping, Iwanowycz, Stephen, Leng, Shuilong, Razani, Babak, Saaoud, Fatma, Sergin, Ismail, Wang, Junfeng, Wang, Yuzhen   +7 more
core   +2 more sources

MiR-361-5p/abca1 and MiR-196-5p/arhgef12 Axis Involved in γ-Sitosterol Inducing Dual Anti-Proliferative Effects on Bronchial Epithelial Cells of Chronic Obstructive Pulmonary Disease

International Journal of COPD, 2021
Hui-fen Shen,1,* Ying Liu,1,* Ping-ping Qu,1 Yu Tang,1 Bing-bing Li,2 Guo-liang Cheng2 1Yantai Affiliated Hospital of Binzhou Medical University, Yantai, 264000, People’s Republic of China; 2State Key Laboratory of Generic Manufacture Technology ...
Shen HF, Liu Y, Qu PP, Tang Y, Li BB, Cheng GL   +5 more
doaj  

Feedback modulation of cholesterol metabolism by the lipid-responsive non-coding RNA LeXis. [PDF]

, 2016
Liver X receptors (LXRs) are transcriptional regulators of cellular and systemic cholesterol homeostasis. Under conditions of excess cholesterol, LXR activation induces the expression of several genes involved in cholesterol efflux, facilitates ...
Casero, David, Eskin, Ascia, Gilliland, Thomas, Hong, Cynthia, Jones, Marius C, Katz, Melanie, Lee, Richard, Sallam, Tamer, Sandhu, Jaspreet, Tontonoz, Peter, Vallim, Thomas Q de Aguiar, Whitelegge, Julian, Wu, Xiaohui, Zhang, Li   +13 more
core   +2 more sources

Characterization of Redox-Responsive LXR-Activating Nanoparticle Formulations in Primary Mouse Macrophages

Molecules, 2019
Activation of the transcription factor liver X receptor (LXR) has beneficial effects on macrophage lipid metabolism and inflammation, making it a potential candidate for therapeutic targeting in cardiometabolic disease.
Tyler K. T. Smith, Zaina Kahiel, Nicholas D. LeBlond, Peyman Ghorbani, Eliya Farah, Refel Al-Awosi, Marceline Cote, Suresh Gadde, Morgan D. Fullerton   +8 more
doaj   +1 more source

Three patients with homozygous familial hypercholesterolemia: Genomic sequencing and kindred analysis. [PDF]

, 2019
BackgroundHomozygous Familial Hypercholesterolemia (HoFH) is an inherited recessive condition associated with extremely high levels of low-density lipoprotein (LDL) cholesterol in affected individuals.
Balamir, Melek, Chu, Catherine, Gonzaludo, Nina, Grenville, Zoe, Kane, John P, Kwok, Pui-Yan, Lao, Richard, Levy-Sakin, Michal, Ma, Walfred, Mak, Angel CY, Malloy, Mary J, Poon, Annie, Pullinger, Clive R, Vaka, Dedeepya, Wong, Karen HY, Wong, Nicolas   +15 more
core   +1 more source