Results 31 to 40 of about 4,110 (154)

Representative Western blots for ABCC4 and actin.

, 2014
ABCC4 siRNAs (HSS115675 and HSS173510) and negative control siRNA were transfected in A549 cells for 72 h. Protein (5 µg/lane) was subjected to SDS-PAGE and then transferred onto nitrocellulose membranes.
Hiroaki Yamaguchi (440141), Nariyasu Mano (638428), Nobuaki Tanaka (638427)   +2 more
core   +1 more source

Variants in TPMT, ITPA, ABCC4 and ABCB1 genes as predictors of 6-mercaptopurine induced toxicity in children with acute lymphoblastic leukemia [PDF]

Journal of Medical Biochemistry, 2018
Background: Acute lymphoblastic leukemia is the most common childhood malignancy. Optimal use of anti leukemic drugs has led to less toxicity and adverse reactions, and a higher survival rate. Thiopurine drugs, including 6-mercaptopurine, are mostly used
Milošević Goran, Kotur Nikola, Krstovski Nada, Lazić Jelena, Zukić Branka, Stanković Biljana, Janić Dragana, Katsila Theodora, Patrinos George P., Pavlović Sonja, Dokmanović Lidija   +10 more
doaj  

Oral Availability of Cefadroxil Depends on ABCC3 and ABCC4

, 2012
Some cephalosporins, such as cefadroxil, are orally available. H+-coupled peptide transporter 1 mediates the transport of cephalosporins across the apical membrane of enterocytes.
Oude Elferink, Ronald P. J., Kunne, Cindy, Paulusma, Coen C., van de Wetering, Koen, Duijst, Suzanne, de Waart, Dirk R.   +5 more
core   +1 more source

Figure 6: Schematic Model of Platelet ABCC4 Role in HIV

, 2019
In HIV, circulating platelets have increased expression of ABCC4 as consequence of enhanced platelet activation. ABCC4 overexpression on platelet plasma membrane contributes to increased excretion of platelet mediators in the extracellular space ...
Nicole Allen (6821924), Rebecca Dann (6821930), Benjamin Kim (2070352), Aristotelis Tsirigos (7274), Tenzin Lhakhang (3424067), Emanuela Marcantoni (1947223), Matthew R. Cambria (6821927), Tilla Worgall (2517805), Adriana Heguy (596012), Jeffrey S. Berger (4239508), Michael Cammer (552585), Meagan P. O’Brien (6821933)   +11 more
core   +1 more source

Roles of ABCC1 and ABCC4 in Proliferation and Migration of Breast Cancer Cell Lines [PDF]

, 2020
ABCC1 and ABCC4 utilize energy from ATP hydrolysis to transport many different molecules, including drugs, out of the cell and, as such, have been implicated in causing drug resistance.
Floren G. Low, Kiran Shabir, Low, Floren G., James E. Brown, Roslyn M. Bill, Rothnie, Alice J., Bill, Roslyn M., Shabir, Kiran, Brown, James E., Alice J. Rothnie   +9 more
core   +1 more source

An unexpected protein interaction promotes drug resistance in leukemia

Nature Communications, 2017
ABCC4 is a chemotherapeutic drug exporter highly expressed in acute myeloid leukemia. Here, the authors demonstrate that MPP1 anchors ABCC4 to the outer cell membrane mediating drug resistance in leukemic cells and identify antimycin A as a chemical ...
Aaron Pitre, Yubin Ge, Wenwei Lin, Yao Wang, Yu Fukuda, Jamshid Temirov, Aaron H. Phillips, Jennifer L. Peters, Yiping Fan, Jing Ma, Amanda Nourse, Chandrima Sinha, Hai Lin, Richard Kriwacki, James R. Downing, Tanja A. Gruber, Victoria E. Centonze, Anjaparavanda P. Naren, Taosheng Chen, John D. Schuetz   +19 more
doaj   +1 more source

Malaria mosquito antimicrobial defence requires immunity and detoxification gene regulation by Lola

Insect Molecular Biology, EarlyView.
Malaria mosquito antimicrobial defence requires upregulation of lola. Attenuation of lola in the midgut of Anopheles albimanus mosquitoes inhibits the upregulation of immunity genes induced by challenge. Putative target genes of the Lola transcription factor were revealed by lola attenuation, including Cecropin‐C, Draper, PPAF2, Clip‐domain serine ...
Heidi Espadas‐Álvarez, Verónica Valverde‐Garduño   +1 more
wiley   +1 more source

Characteristics of ABCC4 and ABCG2 High Expression Subpopulations in CRC—A New Opportunity to Predict Therapy Response

, 2023
Background: Our previous findings proved that ABCC4 and ABCG2 proteins present much more complex roles in colorectal cancer (CRC) than typically cancer-associated functions as drug exporters.
Jakub Kryczka, Joanna Boncela
core   +1 more source

Impact of NR1I2, adenosine triphosphate–binding cassette transporters genetic polymorphisms on the pharmacokinetics of ginsenoside compound K in healthy Chinese volunteers

Journal of Ginseng Research, 2019
Background: Ginsenoside compound K (CK) is a promising drug candidate for rheumatoid arthritis. This study examined the impact of polymorphisms in NR1I2, adenosine triphosphate–binding cassette (ABC) transporter genes on the pharmacokinetics of CK in ...
Luping Zhou, Lulu Chen, Yaqin Wang, Jie Huang, Guoping Yang, Zhirong Tan, Yicheng Wang, Jianwei Liao, Gan Zhou, Kai Hu, Zhenyu Li, Dongsheng Ouyang   +11 more
doaj   +1 more source

Physiological and anatomical determinants of placental drug transfer

The Journal of Physiology, EarlyView.
Abstract figure legend Fetal exposure to pharmaceuticals and their subsequent clearance back to the maternal circulation are governed by placental transfer. Passive diffusion down a maternal‐to‐fetal concentration gradient is the primary route of fetal drug exposure, with specific compounds undergoing transporter‐mediated transfer.
Rohan M. Lewis, Anandita Umapathy, Jane K. Cleal, Bram G. Sengers   +3 more
wiley   +1 more source