Results 51 to 60 of about 4,110 (154)

Farnesoid x Receptor Deficiency Promotes Hepatocytic Injury in Cyp2c70‐Deficient Mice With a Human‐Like Bile Acid Composition

Liver International, Volume 46, Issue 5, May 2026.
ABSTRACT Background and Aims Loss‐of‐function mutations in bile acid (BA)‐activated farnesoid x receptor (FXR/NR1H4) cause severe neonatal liver pathology in humans, earlier referred to as progressive familial intrahepatic cholestasis type 5 (PFIC5). However, Fxr‐deficient mice do not develop early‐onset liver disease, possibly due to the predominance ...
Hilde D. de Vries, Jinxiao Li, Kirill Ustyantsev, Milaine V. Hovingh, Niels L. Mulder, Rick Havinga, Anna Palmiotti, Krisztina de Bruyn, Brecht Attema, Ellen Weersing, Rachel E. Thomas, Vincent W. Bloks, Eugene Berezikov, Martijn van Faassen, Henkjan J. Verkade, Jan Freark de Boer, Folkert Kuipers   +16 more
wiley   +1 more source

Gene expression profile of ABC transporters and cytotoxic effect of ibuprofen and acetaminophen in an epithelial ovarian cancer cell line in vitro [PDF]

Revista Brasileira de Ginecologia e Obstetrícia, 2015
PURPOSES: To determine the basic expression of ABC transporters in an epithelial ovarian cancer cell line, and to investigate whether low concentrations of acetaminophen and ibuprofen inhibited the growth of this cell line in vitro.
Renilton Aires Lima, Eduardo Batista Cândido, Flávia Perrim de Melo, Josiane Barbosa Piedade, Paula Vieira Teixeira Vidigal, Luciana Maria Silva, Agnaldo Lopes da Silva Filho   +6 more
doaj   +1 more source

Differential Expression of ABC Transporter Genes in Brain Vessels vs. Peripheral Tissues and Vessels from Human, Mouse and Rat

Pharmaceutics, 2023
Background: ATP-binding cassette (ABC) transporters comprise a superfamily of genes encoding membrane proteins with nucleotide-binding domains (NBD).
Wandong Zhang, Qing Yan Liu, Arsalan S. Haqqani, Ziying Liu, Caroline Sodja, Sonia Leclerc, Ewa Baumann, Christie E. Delaney, Eric Brunette, Danica B. Stanimirovic   +9 more
doaj   +1 more source

Deconvoluting Gut Versus Liver Cytochrome P450 3A4 Function: Drug Probes, Biomarkers, and Tissue Biopsy

The Journal of Clinical Pharmacology, Volume 66, Issue 2, February 2026.
Abstract Cytochrome P450 3A4 (CYP3A4) is an important drug‐metabolizing enzyme, whose function is impacted by age, sex, body weight, pregnancy, and disease. It is also the site of major drug interactions involving inhibition and induction. Because CYP3A4 is expressed in the intestine and liver, investigators have sought to study its function in both ...
David Rodrigues
wiley   +1 more source

Pharmacogenomics of Thiopurine Drugs: A Bench‐To‐Bedside Success Story in Thailand

Clinical and Translational Science, Volume 19, Issue 2, February 2026.
ABSTRACT Thiopurine drugs are the cornerstone treatment for many diseases such as acute lymphoblastic leukemia (ALL), organ rejection, inflammatory bowel disease (IBD), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and other autoimmune diseases.
Mohitosh Biswas, Shobana John, Murshadul Alam Murad, Chonlaphat Sukasem   +3 more
wiley   +1 more source

Zebrafish Abcc4 has functions in transport of MCB out of LLC-PK1 cells.

, 2014
(A) Western blot analysis of Flag-tagged Abcc4 or Abcc4-G1188D in stably transfected LLC-PK1 cells and the control cells (CTRL) transfected with empty vectors. The β-actin was used as a loading control.
Xing Lu (1438414), Yong Long (138508), Rongze Sun (670595), Li Lin (111038), Zongbin Cui (138513), Shan Zhong (380109)   +5 more
core   +1 more source

A Role of the ABCC4 Gene Polymorphism in Airway Inflammation of Asthmatics

Mediators of Inflammation, 2017
The ATP-binding cassette subfamily C member 4 gene encodes a transmembrane protein involved in the export of proinflammatory molecules, including leukotriene, prostaglandin, and sphingosine-1-phosphate across the plasma membrane.
Sailesh Palikhe, Udval Uuganbayar, Hoang Kim Tu Trinh, Ga-Young Ban, Eun-Mi Yang, Hae-Sim Park, Seung-Hyun Kim   +6 more
doaj   +1 more source

Zebrafish Abcc4 plays crucial roles in cellular detoxification of DDT and lindane.

, 2014
(A) Death rates of 96-hpf embryos expressing GFP, Abcc4 or Abcc4-G1188D were monitored after treatment with 100 µg/L DDT or lindane. (B) Embryos injected with pT2/CMV2-Abcc4 or pT2/CMV2-GFP were exposed to 100 µg/L DDT or lindane from 24 to 96 hpf ...
Xing Lu (1438414), Yong Long (138508), Rongze Sun (670595), Li Lin (111038), Zongbin Cui (138513), Shan Zhong (380109)   +5 more
core   +1 more source

Genome-wide association study identifies candidate loci associated with chronic pain and postherpetic neuralgia

Molecular Pain, 2021
Background Human twin studies and other studies have indicated that chronic pain has heritability that ranges from 30% to 70%. We aimed to identify potential genetic variants that contribute to the susceptibility to chronic pain and efficacy of ...
Daisuke Nishizawa, Masako Iseki, Hideko Arita, Kazuo Hanaoka, Choku Yajima, Jitsu Kato, Setsuro Ogawa, Ayako Hiranuma, Shinya Kasai, Junko Hasegawa, Masakazu Hayashida, Kazutaka Ikeda   +11 more
doaj   +1 more source

Differential Regulation of Hepatic Cholesterol Metabolism by Water Extract or Residue of Large‐Leaf Yellow Tea in High‐Fat Diet‐Fed Mice

Food Frontiers, Volume 7, Issue 1, January 2026.
This study investigates the lipid metabolism regulatory effects of large‐leaf yellow tea (YT), its aqueous extract (YAE), and its tea residue (YSR) in a high‐fat diet‐induced mouse model. we evaluated their effects on serum lipid metabolism indices and explored potential mechanisms of intervention through transcriptome analysis.
Yuzhu Shen, Denghuan Luo, Fengjuan Lu, Rongrong Dong, Xiaochun Wan, Yijun Wang, Hongyan Wang, Ying Zhang, Jun Chu, Jinbao Huang, Na Xu   +10 more
wiley   +1 more source