Results 61 to 70 of about 4,110 (154)

Mass spectrometry in ocular drug research

Mass Spectrometry Reviews, Volume 45, Issue 1, Page 37-68, January/February 2026.
Abstract Mass spectrometry (MS) has been proven as an excellent tool in ocular drug research allowing analyzes from small samples and low concentrations. This review begins with a short introduction to eye physiology and ocular pharmacokinetics and the relevance of advancing ophthalmic treatments.
Eva M. del Amo, Kati‐Sisko Vellonen, Arto Urtti, Tetsuya Terasaki, Anam Hammid, Paavo Honkakoski, Seppo Auriola   +6 more
wiley   +1 more source

Abstract 1528: Abcc4 (Mrp4)-deficiency leads to decreased oral absorption of dasatinib

, 2010
Dasatinib, an orally available multikinase inhibitor, has been recently approved for imatinib- resistant chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia.
Li Lie, Brian D. Furmanski, Sharyn D. Baker, Shelley Orwick, John D. Schuetz, Praveen Potukuchi, Alex Sparreboom, Ken-ichi Fujita   +7 more
core   +1 more source

French‐Speaking Network of Pharmacogenetics (RNPGx) Recommendations for Gene Panel Analysis Through Genotyping or Sequencing in Pharmacogenetics

Fundamental &Clinical Pharmacology, Volume 40, Issue 1, January 2026.
ABSTRACT Background The implementation of pharmacogenetics in clinical practice increasingly relies on multigene panels. Objectives The objective of this study is to develop harmonized recommendations for the design and analytical implementation of multigene pharmacogenetic panels, defining clinically relevant genes and associated regions of interest ...
Nicolas Picard, Estelle Ayme‐Dietrich, Sylvie Quaranta, Tiphaine Adam‐De‐Beaumais, Abd El Kader Ait Tayeb, Hugo Alarcan, Dorra Amor, David Barthelemy, Mouna Ben Sassi, Séverine Cunat, Mouna Daldoul, Hervé Delacour, Marie‐Christine Etienne‐Grimaldi, Xavier Fonrose, Benjamin Hennart, Louis Lebreton, Stephanie Malard, Céline Narjoz, Asma Omezzine, Nicolas Pallet, Léa Payen, Jeanne Petit, Fabienne Thomas, Sameh Trabelsi, Camille Tron, Céline Verstuyft, Paul Vilquin, Jean‐Christophe Boyer, Vincent Haufroid, French‐Speaking Network of Pharmacogenetics (RNPGx)   +29 more
wiley   +1 more source

Arsenic Cellular Handling by Human Multidrug Resistance Protein 1 (MRP1/ABCC1) and MRP4 (ABCC4)

, 2021
Arsenic is a proven human carcinogen to which hundreds of millions of people are chronically exposed at unsafe levels, primarily through contaminated drinking water.
Whitlock, Brayden D
core   +2 more sources

The expression ofABCC4/MRP4andABCC5/MRP5gene in the NK/T cell lymphoma and its relationship with clinical efficacy

Zhongguo aizheng zazhi, 2014
Background and purpose: Natural killer/T cell lymphoma in poor effects, the production of multidrug resistance is one of the reasons to reduce the chemotherapy effect or failure.
李汝平, 韩丽娟, 张旭东, 张明智, 胡腾鹏, 秦贝贝, 文建国   +6 more
doaj  

Population Pharmacokinetic and Pharmacodynamic Analysis of Voriconazole‐Induced Liver Injury in Chinese Lung Transplant Patients

Journal of Clinical Pharmacy and Therapeutics, Volume 2026, Issue 1, 2026.
Background Voriconazole (VCZ) served as primary therapy for invasive aspergillosis in lung transplant recipients. However, VCZ‐induced hepatotoxicity emerged as a frequent adverse effect that critically compromised postoperative management and complication prevention in this vulnerable population.
Dan Zhang, Wenwen Du, Wei Qin, Bo Li, Pengmei Li, Xiaoxing Wang, Wenqian Chen, Anjali Chauhan   +7 more
wiley   +1 more source

Lack of the multidrug transporter MRP4/ABCC4 defines the PEL-negative blood group and impairs platelet aggregation

, 2019
International audienceThe rare PEL-negative phenotype is one of the last blood groups with an unknown genetic basis. By combining whole-exome sequencing and comparative global proteomic investigations, we found a large deletion in the ABCC4/MRP4 gene ...
Robitaille, Nancy, Vrignaud, Cedric, Azouzi, Slim, Gautier, Emilie-Fleur, Salnot, Virginie, Ethier, Carole, Jedlitschky, Gabriele, Le van Kim, Caroline, Hermand, Patricia, Nicolas, Gaël, Hermine, Olivier, Mayeux, Patrick, Nitschké, Patrick, Raneri, Alexandre, Cartron, Jean-Pierre, Colin, Yves, Bole-Feysot, Christine, Willemetz, Alexandra, Cloutier, Marc, Mikdar, Mahmoud, Constanzo-Yanez, Jessica, St-Louis, Maryse, Peyrard, Thierry   +22 more
core   +1 more source

Expression and DNA methylation of 20S proteasome subunits as prognostic and resistance markers in cancer

Molecular Oncology, Volume 19, Issue 12, Page 3729-3749, December 2025.
Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla, Simone Venz, Ruslan Al‐Ali, Martin Wendlandt, Mandy Radefeldt, Elke Krüger   +5 more
wiley   +1 more source

Kinetic parameters of ABCC4-mediated prostanoids.

, 2014
Rates of ATP-dependent transport were calculated by subtracting the uptake in the presence of AMP from that in the presence of ATP for three independent experiments. The values of Km and Vmax were calculated from Eadie-Hofstee plots. Data represent mean ±
Hiroaki Yamaguchi (440141), Nariyasu Mano (638428), Nobuaki Tanaka (638427)   +2 more
core   +1 more source

Lamivudine and tenofovir pharmacokinetic variability in people with HIV in Papua New Guinea

British Journal of Clinical Pharmacology, Volume 91, Issue 12, Page 3412-3421, December 2025.
Aims Demographics and kidney function contribute to variability in lamivudine and tenofovir drug concentrations. The aim was to assess, for the first time, the pharmacokinetic variability of lamivudine and tenofovir in Papua New Guinean (PNG) HIV/AIDS patients.
Natália Bordin Andriguetti, Daniel Thomas Barratt, Joseph Tucci, Paul Pumuye, Andrew Alexander Somogyi   +4 more
wiley   +1 more source