Results 181 to 188 of about 6,676 (188)

Multidrug resistance protein 4 (MRP4/ABCC4)

Trends in Pharmacological Sciences, 2008
Multidrug resistance protein (MRP) 4 is a member of the MRP/ABCC subfamily of ATP-binding cassette transporters, which are capable of pumping a wide variety of endogenous and xenobiotic organic anionic compounds out of the cell. In addition to its role in the body distribution and renal excretion of a wide variety of antiviral, cytostatic, antibiotic ...
Russel, Frans G M, Koenderink, Jan B, Masereeuw, R.   +2 more
openaire   +1 more source

The ABCC4 gene is a promising target for pancreatic cancer therapy

Gene, 2012
Pancreatic cancer is a malignant neoplasm of the pancreas that usually has a poor prognosis. The investigation of targets that effectively inhibit pancreatic cancer cell proliferation should provide a fundamental basis for the clinical application of gene therapy.
Zhuo, Zhang, Jiancheng, Wang, Baiyong, Shen, Chenghong, Peng, Minhua, Zheng   +4 more
openaire   +2 more sources

Multidrug resistance protein 4 (MRP4/ABCC4) mediates efflux of bimane-glutathione

The International Journal of Biochemistry & Cell Biology, 2004
Multidrug resistance proteins (MRPs) are ATP-dependent export pumps that mediate the export of organic anions. ABCC1 (MRP1), ABCC2 (MRP2) and ABCC3 (MRP3) are all able to facilitate the efflux of anionic conjugates including glutathione (GSH), glucuronide and sulfate conjugates of xenobiotics and endogenous molecules.
Bai, J., Lai, L., Tan, T.M.C., Yeo, H.C., Goh, B.C.   +4 more
openaire   +2 more sources

ABCC4 impacts megakaryopoiesis and protects megakaryocytes against 6-mercaptopurine induced cytotoxicity

Drug Resistance Updates
The role of ABCC4, an ATP-binding cassette transporter, in the process of platelet formation, megakaryopoiesis, is unknown. Here, we show that ABCC4 is highly expressed in megakaryocytes (MKs). Mining of public genomic data (ATAC-seq and genome wide chromatin interactions, Hi-C) revealed that key megakaryopoiesis transcription factors (TFs) interacted ...
Sabina, Ranjit, Yao, Wang, Jingwen, Zhu, Satish B, Cheepala, Erin G, Schuetz, Woo Jung, Cho, Beisi, Xu, Camenzind G, Robinson, Gang, Wu, Anjaparavanda P, Naren, John D, Schuetz   +10 more
openaire   +2 more sources

Androgen regulation of multidrug resistance‐associated protein 4 (MRP4/ABCC4) in prostate cancer

The Prostate, 2008
AbstractBACKGROUNDMRP4/ABCC4 is an ATP‐binding cassette transporter expressed in normal prostate. This study aimed to define the pattern of MRP4/ABCC4 expression in normal and malignant prostate tissue and the relationship of MRP4/ABCC4 expression and function in response to androgen signaling.METHODSEighty‐four radical prostatectomy specimens from ...
Ho, L.L., Kench, J.G., Handelsman, D.J., Scheffer, G.L., Stricker, P.D., Grygiel, J.G., Sutherland, R.L., Henshall, S.M., Allen, JD, Horvath, L.G.   +9 more
openaire   +3 more sources

ABCC4 Impacts Megakaryopoiesis by Regulating Intracellular cAMP levels

The Journal of Pharmacology and Experimental Therapeutics, 2023
Sabina Ranjit, Yao Wang, Satish B. Cheepala, Jingwen Zhu, Woo Jung Cho, Cam Robinson, Scott Olsen, John Schuetz   +7 more
openaire   +1 more source

Protein Kinase A Activation Promotes ABCC4 Protein Network Assembly

The Journal of Pharmacology and Experimental Therapeutics
Sabina Ranjit, Jingwen Zhu, Tomoka Gose, Amanda Nourse, Vishwajeeth Pagala, Yao Wang, Aaron Pitre, Rebecca Crawford, Junmin Peng, Juwina Wijaya, Anjaparavanda P. Naren, John Schuetz   +11 more
openaire   +1 more source

Polymorphisms of ABCC2, ABCC4, ABCC10 andSLC22A6 in Thai HIV - infected patients

Chulalongkorn Medical Journal, 2014
openaire   +1 more source