Results 91 to 100 of about 1,668,474 (258)

Diabetes‐Associated Cognitive Impairment: Pathophysiology and Emerging Therapies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Diabetes‐associated cognitive impairment (DACI) is a common yet underrecognized condition, manifesting along a spectrum from mild cognitive impairment to dementia. DACI encompasses patients who develop vascular dementia (VaD) or Alzheimer's disease (AD) with diabetes as a risk factor; however, in certain patients, particularly those lacking ...
Osman Corbali, Priyanka Menon, Halil I. Corbali, Ram Jagannathan, Allan I. Levey   +4 more
wiley   +1 more source

Management of Acute Abdomen: Acute Appendicitis

Journal of Gandaki Medical College, 2019
Background: Traditionally, appendectomy has been the treatment of choice for acute appendicitis but many times diagnosis can be difficult. Clinicians are looking through different ways to come to the correct diagnosis to decrease negative appendectomy ...
B. R. Neupane, S. R. Paudel, A. Shrestha, S. `M. Bijukchhe, A. Bhattarai, P. Subedi   +5 more
doaj   +1 more source

‘ACUTE ABDOMEN’ WITH A RASH

International Journal of Clinical Practice, 2000
SUMMARYA previously fit and healthy 17‐year‐old male presented with the clinical symptoms and signs of an acute abdomen and with the secondary complaint of a rash. In view of the primary presenting complaint he was admitted to the surgical ward. The patient was initially booked for an emergency exploratory laparotomy, but after reassessment on the ward
D A, Lannon, Y M, Smyth, R, Waldron
openaire   +2 more sources

Multi-detector computed tomography of acute abdomen [PDF]

, 2018
Acute abdominal pain is one of the most common causes for referrals to the emergency department. The sudden onset of severe abdominal pain characterising the "acute abdomen” requires rapid and accurate identification of a potentially life-threatening ...
Marincek, Borut, Alkadhi, Hatem, Leschka, Sebastian, Wildermuth, Simon   +3 more
core  

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Integrative transcriptomic and machine learning analysis identifies key extracellular matrix-related genes in diabetic retinopathy

Scientific Reports
Extracellular matrix (ECM) remodeling contributes to retinal vascular basement membrane thickening, an early structural hallmark of diabetic retinopathy (DR). This study aimed to identify key ECM-related genes (ECMGs) associated with DR.
Wang Xin, Wang Ying, Feng Qiang, Chen Yan, Zhang Wei   +4 more
doaj   +1 more source

Acute abdomen as a consequence of an unusual suicide attempt: intra-abdominal injection of sulfuric acid

, 2016
Anna Lepore,1 Davide D’Antini,1 Pasquale Raimondo,2 Lucia Mirabella,1 Leonardo Pennisi,1 Giuseppe Carrillo,1 Antonella Cotoia,1 Michele Dambrosio,1 Gilda Cinnella1 1Department of Anesthesia and Intensive Care, University of Foggia, Viale Pinto ...
Cotoia A, Lepore A, D'Antini D, Raimondo P, Dambrosio M, Mirabella L, Pennisi L, Carrillo G, Cinnella G   +8 more
core  

Copine‐4 Paraneoplastic Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT We characterize copine‐4 (CPNE4)‐IgG and report clinical associations. Among 844 samples with unclassified neural IgGs identified by mouse‐brain indirect immunofluorescence assay over 2 years, 5 samples (serum, 3; CSF, 2) from 3 patients produced a distinctive cerebrum‐restricted synaptic pattern.
Mimi S. Fang, Amy Ml Quek, Clement Yong, Amir Adeli, Gabrielle N. Conway, Connie E. Lesnick, Diana Anissian, Divyanshu Dubey, John R. Mills, Sean J. Pittock, Anastasia Zekeridou, Michael Gilligan, Andrew McKeon   +12 more
wiley   +1 more source

Glucagon‐Like Peptide‐1 Receptor Agonists in Multiple Sclerosis: A Topical Narrative Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The glucagon‐like peptide‐1 (GLP‐1) receptor agonists (RAs) are a relatively new class of drugs that were initially approved by the US Food and Drug Administration to improve glycemic control in patients with type 2 diabetes mellitus and, subsequently, weight reduction in patients with obesity.
Audrey Y. Chang, Farrah J. Mateen
wiley   +1 more source

Risk factors for diabetic retinopathy in young and middle-aged patients: a retrospective study

BMC Ophthalmology
Aims/Introduction To investigate the related risk factors of retinopathy in young and middle-aged diabetic patients in order to improve the prognosis of patients.
Zhihui Wang, Xiaowen Bai, Mengdi Wang, Fei Li, Tong Sun, Wenjuan Liu, Zhenghua Xu, Dan Shen, Lu Wang, Meng li, Lian cai, Jinting Li, Yongxia Ren   +12 more
doaj   +1 more source