Results 241 to 250 of about 3,350,942 (312)

PRMT9 Aggravated Dopaminergic Neurodegeneration in Parkinson's Disease Model by Facilitating the Degradation of DUSP26 and Inducing Mitochondrial Dysfunction

Advanced Science, EarlyView.
In the pathological state of PD induced by MPP+, the upregulated PRMT9 in dopaminergic neurons translocates into mitochondrion and interacts with DUSP26 and catalyzes its arginine methylation, leading to the ubiquitin‐proteasomal degradation of DUSP26 mediated by Trim32.
Tengfei Liu, Xiaomeng Song, Xin Guo, Rui Xiao, Ru Sun, Qiuran Ji, Lu Yu, Yiquan Li, Qingyi Fu, Qidi Xue, Lingjun Kong, Lin Chen, Chengjiang Gao, Huiqing Liu   +13 more
wiley   +1 more source

The Silent Abdomen: The Conservative Management of Large Idiopathic Pneumoperitoneum. [PDF]

Cureus
Liu Y, Auld M, Stieler G.
europepmc   +1 more source

Intrinsically Mitochondria‐Targeting Nanozyme via Coordination‐Assembly of Natural Quercetin for Cascade Antioxidant Therapy of Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
This study uncovers that quercetin naturally targets mitochondria. By coordinating quercetin with Fe3+, we engineer an ultrasmall cascade nanozyme (MCN) with superoxide dismutase‐catalase activities. MCN crosses the damaged blood–brain barrier, scavenges mitochondrial ROS, prevents mitochondrial DNA leakage, and blocks the cGAS‐STING pathway, thereby ...
Wenxuan Zheng, Zhicheng Wang, Xin Zhou, Shuya Wang, Xiaojing Shi, Tingli Xiong, Ruishi Li, Yuting Lin, Zhen Chen, Jiawen Wei, Fei Li, Jinwen Ge, Kelong Ai, Chong Liu, Guiming Deng   +14 more
wiley   +1 more source

Nirmatrelvir-Ritonavir-Induced Pancreatitis: A Concern in the COVID Era. [PDF]

ACG Case Rep J
DeBroff J, Abraham J, Yoon BH, Cohen I.
europepmc   +1 more source

Pharmacological Inhibition of FKBP51 Mitigates Early Life Adversity‐Induced Social Deficits in Male Mice

Advanced Science, EarlyView.
Early life adversity triggers persistent social subordination and brain‐wide molecular dysregulation. Pharmacological inhibition of the stress‐mediator FKBP51 during the adversity period prevents these long‐term deficits and restores normative social hierarchy.
Joeri Bordes, Xiuqi Ji, Serena Gasperoni, Choham Sudre‐Chinsky, Amirali Kalbasi, Daniela Harbich, Cornelia Flachskamm, Paula Fontanet, Sowmya Narayan, Manfred Uhr, Christian Namendorf, Camilla Bellone, Alon Chen, Felix Hausch, Juan Pablo Lopez, Mathias V. Schmidt   +15 more
wiley   +1 more source

Duodenal ulcer perforation presenting as acute appendicitis in a child: a case report and literature review. [PDF]

Front Surg
Jin Z, Yang X, Liu Y, Yao B, Chen X, Liang L.   +5 more
europepmc   +1 more source

Catastrophic Antiphospholipid Syndrome: When STEMI Is Not Atherosclerotic. [PDF]

JACC Case Rep
Choudhury SH, Wexler A, Shah M, Farooq S, McGrody KS.   +4 more
europepmc   +1 more source

Adult Malrotation With Midgut Volvulus: A Case Requiring Temporary Abdominal Closure and Second-Look Operation. [PDF]

Cureus
Finkenthal TA, Kondajji A.
europepmc   +1 more source

Necrotizing pancreatitis with multifocal hepatic artery pseudoaneurysms: Diagnostic limitations and rare appearance of suspected IgG-4 related disease. [PDF]

Radiol Case Rep
du Preez L, Krebs T, Webster P, Reiner E.   +3 more
europepmc   +1 more source

Neonatal torsion of the vermiform appendix presenting as generalized peritonitis: a case report of a 10-day-old infant. [PDF]

Int J Surg Case Rep
Chu LV, Huynh QTV, Quy TL, Ban HT.
europepmc   +1 more source