Results 51 to 60 of about 205,808 (310)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Association of α-SMA/FAP-positive cancer-associated fibroblasts with clinicopathological features and prognosis in extrahepatic cholangiocarcinoma

Diagnostic Pathology
Objective This study aimed to evaluate the value of cancer-associated fibroblasts (CAFs) that positively express α-smooth muscle actin (α-SMA) and fibroblast activation protein (FAP) as survival indicators for patients with extrahepatic ...
Xiaojun Sui, Zhangqiang Zheng, Lei Yang, Dapeng Zhang, Xiangyu Sun, Ximo Wang   +5 more
doaj   +1 more source

Rapunzel syndrome, a rare hairy tale: a case report [PDF]

Pediatric Emergency Medicine Journal
Rapunzel syndrome is a rare condition that typically occurs in young females with trichotillomania or trichophagia. The name “Rapunzel” was given due to the presence of trichobezoars extending from the stomach down to various parts of the ...
Nevine Macalintal, Shoshana Taube, Vinci Jones, Cornelia Muntean   +3 more
doaj   +1 more source

Estudo comparativo da celularidade da reação inflamatória aguda na serosa e mesentério intestinais às telas de poliamida e polipropileno em ratos wistar com peritonite fecal por técnica morfométrica [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-graduação em Ciências Médicas, Florianópolis, 2004A peritoneostomia é um recurso tático na condução de pacientes com peritonite aguda grave e ...
Russi, Ricardo Fantazzini
core  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Machine learning-based integration of DCE-MRI radiomics for STAT3 expression prediction and survival stratification in breast cancer

Frontiers in Immunology
ObjectiveTo explore the association between signal transducer and activator of transcription 3 (STAT3) expression, tumor immune microenvironment, and overall survival (OS) in breast cancer, and to develop a non-invasive radiomics model for early risk ...
Dong Pan, Dong Pan, Dong Pan, Cheng-Yan Zhang, Cheng-Yan Zhang, Cheng-Yan Zhang, Ya-Fei Wang, Ya-Fei Wang, Shuang Liu, Shuang Liu, Shuang Liu, Xiong-Zhi Wu, Xiong-Zhi Wu, Xiong-Zhi Wu, Xiong-Zhi Wu, Xiong-Zhi Wu   +15 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Acute pancreatitis risk in the diagnosis and management of inflammatory bowel disease: A critical focus

Open Medicine
We explored the causal relationship between pancreatitis and various autoimmune diseases using bidirectional Mendelian randomization (MR).
Zheng Feibo, Li Jinan, Ma Lina, Zhang Yu, Tu Zhengwei, Cui Yunfeng   +5 more
doaj   +1 more source

Ultrasonography in the acute abdomen

Journal of British Surgery, 1991
Abstract In a prospective study 152 consecutive patients presenting with acute abdominal pain were assessed clinically and an ultrasonographic examination was performed immediately. Of these, 16 (11 per cent) patients would normally have had an immediate ultrasonographic scan requested; routine (within 24 h of admission) ultrasonographic
A H, Davies, I, Mastorakou, R, Cobb, C, Rogers, D, Lindsell, N J, Mortensen   +5 more
openaire   +2 more sources