Results 71 to 80 of about 312,600 (314)

Outcomes and costs of penetrating trauma injury in England and Wales [PDF]

, 2008
The official published version of the article can be found at the link below.Background: Penetrating trauma injury is generally associated with higher short-term mortality than blunt trauma, and results in substantial societal costs given the young age ...
Christensen, MC, Lecky, FE, Morris, S, Nielsen, TG, Ridley, S   +4 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Identification and validation of parthanatos-related genes in end-stage renal disease

Renal Failure
Background End-Stage Renal Disease (ESRD) is a severe chronic kidney disease with a rising global incidence, often accompanied by various complications, severely impacting patients’ quality of life. Parthanatos plays a crucial role in the pathogenesis of
Xuan Dai, Lianfang Yuan
doaj   +1 more source

Contribution of us and ct for diagnosis of intra peritoneal focal fat infarction (iffi): a pictorial review

Journal of the Belgian Society of Radiology, 2010
The term IFFI – for Intraperitoneal Focal Fat Infarction – includes various acute abdominal clinical conditions in which focal fatty tissue necrosis represents the common pathologic denominator.
B Coulier
doaj   +1 more source

A remarkable new Anomiopus Westwood from Peru (Coleoptera: Scarabaeidae: Scarabaeinae) [PDF]

, 2013
Described and illustrated is a strikingly distinct new species of the scarabaeine genus Anomiopus Westwood, A.
Edmonds, William David, Figueroa, Luis
core   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

The Western North American Genus Androlyperus Crotch, 1873 (Coleoptera: Chrysomelidae: Galerucinae) [PDF]

, 1999
The five previously known species of Androlyperus are redescribed and diagnosed. Androlyperus nataliae n. sp. is described from the Baja California Peninsula, Mexico.
Clark, Shawn M.
core  

Primary intestinal aspergillosis resulting in acute intestinal volvulus after autologous stem cell transplantation in a patient with relapsed non-Hodgkin lymphoma : report on a rare infectious complication and a review of the literature

, 2019
Objectives: Since primary intestinal aspergillosis is a severe infectious complication with a high morbidity and mortality in immunocompromised patients, we want to draw attention to this rare entity and the importance of early recognition.
Kennes, Soetkin, Kerre, Tessa, Van de Putte, Dirk, Van Dorpe, Jo, VAN HENDE, VANESSA, Vlummens, Philip   +5 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Acute abdomen presentation in dengue fever during recent outbreak

Journal of Acute Disease, 2017
Objective: To evaluate the etiology, clinical profile and outcome of acute abdomen presentation in Dengue Fever (DF).Methods: This clinical prospective study was done on confirmed cases of DF admitted in the department of medicine during recent epidemic (
Bal Kishan Gupta, Hardeva Ram Nehara, Sahil Parmar, Shyam Lal Meena, Suresh Gajraj, Jigyasa Gupta   +5 more
doaj   +1 more source