Results 101 to 110 of about 1,075,356 (291)
m6A‐Driven Pexophagy Triggers Placental Ferroptosis to Impair Fetal Growth Upon Environmental Stress
Advanced Science, EarlyView.Prenatal environmental stress exposure promotes m6A modification to drive PEX2‐dependent pexophagy, thereby causing placental ferroptosis and FGR. ABSTRACT
The role and underlying mechanisms of placental ferroptosis in fetal growth restriction (FGR) induced by environmental stress remain poorly understood.Xin‐Xin Zhang, Ye‐Xin Luo, Cheng‐Fang Sun, Rui Pan, Yu‐Xi Wu, Zhi Yuan, Xin‐Run Wang, Xu‐Dong Zhang, Lan‐Lan Wu, Xiang‐Yu Yao, Zhan‐Dong Song, Wei Chang, Tian Wei, Pan‐Yuan Cai, Tian‐Ci Zhang, Yong‐Wei Xiong, De‐Xiang Xu, Hua Wang, Hua‐Long Zhu +18 morewiley +1 more sourceThe missing risk: MRI and MRS phenotyping of abdominal adiposity and ectopic fat
, 2012 Individual compartments of abdominal adiposity and lipid content within the liver and muscle are differentially associated with metabolic risk factors, obesity and insulin resistance.Robinson, Simon, Parkinson, J.R.C., Frost, G.S., James R. Parkinson, McCarthy, J., Simon D. Taylor-Robinson, Collins, Adam L., Julie A. Fitzpatrick, John P. McCarthy, Parkinson, James R., Durighel, G., Anthony P. Goldstone, Fitzpatrick, Julie, Thomas, E. Louise, Doré, Caroline J., Taylor-Robinson, S.D., McCarthy, John, Thomas, E.L., Goldstone, A.P., Giuliana Durighel, Caroline J. Doré, Bell, J.D., E. Louise Thomas, Frost, Gary S., Fitzpatrick, J., Bell, Jimmy D., Doré, C.J., Adam L. Collins, Gary S. Frost, Goldstone, Anthony P., Jimmy D. Bell, Collins, A.L., Durighel, Giuliana +32 morecore +1 more sourceClinicopathological Profile and Surgical Treatment of Abdominal Tuberculosis: A Single Centre Experience in Northwestern Tanzania. [PDF]
, 2013 Abdominal tuberculosis continues to be a major public health problem worldwide and poses diagnostic and therapeutic challenges to general surgeons practicing in resource-limited countries.Hyasinta Jaka, Joseph B Mabula, Mabula D Mchembe, Stephen E Mshana, Peter F Rambau, Chalya, Phillipo L, Mshana, Stephen E, Rambau, Peter F, McHembe, Mabula D, Phillipo L Chalya, Jaka, Hyasinta, Mabula, Joseph B +11 morecore +2 more sourcesGSTM4 Suppresses Prostate Cancer Progression by Targeting TRIM27‐mediated ACLY Ubiquitination and Lipid Metabolism
Advanced Science, EarlyView.GSTM4 enhances the interaction between ACLY and the E3 ubiquitin ligase TRIM27, thereby increasing K48‐linked ubiquitination at the K554 site of ACLY and promoting its degradation. Consequently, GSTM4 regulates lipid synthesis, as well as the proliferation and metastasis of PCa cells, by modulating ACLY stability.Kang‐Ping Xiong, Fei Liu, Wang Wang, Gang Wang, Kai‐Yu Qian, Sheng Tu, Si‐Ming Chen, Hui‐Min Xu, Shan‐Shan Zhang, Yong Li, Xing‐Huan Wang, Hong Weng +11 morewiley +1 more sourceCommonly applied positive end-expiratory pressures do not prevent functional residual capacity decline in the setting of intra-abdominal hypertension: a pig model [PDF]
, 2010 Introduction
Intra-abdominal hypertension is common in critically ill patients and is associated with increased morbidity and mortality. The optimal ventilation strategy remains unclear in these patients.Brigit Roberts, Bill Noffsinger, Musk, Gabrielle C, Bhajan Singh, Hockings, Lisen E, Peter V van Heerden, Noffsinger, B., Lisen E Hockings, Regli, Adrian, van Heerden, Peter V, Singh, Bhajan, Singh, B., Roberts, B., Noffsinger, Bill, Regli, A., Gabrielle C Musk, Adrian Regli, Hockings, L.E., Musk, G.C., van Heerden, P.V., Roberts, Brigit +20 morecore +1 more sourceRestoration of m6A‐Modified circPSMB1 Suppresses Chordoma Progression and Enables Local Nanotherapeutic Intervention
Advanced Science, EarlyView.An m6A‐modified circRNA, circPSMB1, is identified as a tumor suppressor in chordoma. METTL3‐dependent m6A promotes circPSMB1 interaction with HNRNPA2B1, limiting c‐MYC expression and malignant progression. An injectable HMnO2‐based nanohydrogel enables local circPSMB1 delivery and tumor microenvironment‐responsive therapy, offering a promising strategy Yingchuang Tang, Liang Qiu, Xingbang Ruan, Yihan Shi, Ye Wang, Hanwen Li, Kai Zhang, Kangwu Chen +7 morewiley +1 more sourceComplicated intra-abdominal infections in a worldwide context: an observational prospective study (CIAOW Study) [PDF]
, 2013 Despite advances in diagnosis, surgery, and antimicrobial therapy, mortality rates associated with complicated intra-abdominal infections remain exceedingly high.Pereira Junior, Gerson Alves, Pereira GA, El Zalabany T., Tugnoli G, Yuan, Kuo-Ching, Ishii W., Massalou D, Jovine, Elio, Abbas A., Malangoni M., Sartelli M, Guercioni G, di Saverio S., Balogh Z, Trana C., Kok K. Y. Y., di Saverio S, Wataru Ishii, Marwah S, Rajeev Sharma, Sartelli M., Carlos Augusto Gomes, Attri AK, Elia Poiasina, Sanjuan, Juan, Kong V., Massalou, Damien, Ordonez, Carlos, Zsolt Balogh, Boonying Siribumrungwong, Norio Sato, di Saverio, Salomone, Ansaloni L, Jovine E., Irahara, Takayuki, Sanjuan J, BAIOCCHI, Gian Luca, Alberto Tavares, Offir Ben-Ishay, Ben Ishay O, Luca Ansaloni, Shoko T, Jae Gil Lee, Bendinelli, Cino, Carlos Ordonez, Bendinelli C, Mefire AC, Boris Sakakushev, Suk-Kyung Hong, Baiocchi, Gianluca, Zachariah S, Tomohisa Shoko, Bendinelli C., Kluger Y, Gerych, Ihor, Gupta S, Kong, Victor, Attri A, Velmahos G, Irahara T., Ernest Moore, Salomone di Saverio, Peev MP, Lohsiriwat V, Khalifa K. A., Velmahos, George, Hong, Suk-Kyung, Walter Biffl, Hamedelneel, Ahmed O, Sato N, Rita Barnabé, Siribumrungwong B., Augustin, Goran, Biffl W, Khalifa, Khalid Al, Gerson Alves Pereira Junior, Wagih Ghnnam, Ahmed O Hamedelneel, Biffl W., Helmut Alfredo Segovia Lohse, Agresta F, Ferdinando Agresta, Gerych I., Mefire, Alain Chichom, Kok KY, Segovia Lohse HA, Skrovina M, Varut Lohsiriwat, Gupta, Sanjay, Siribumrungwong B, Ahmed A., Lee JG, Juan Sanjuan, Skrovina M., Kluger Y., Kobe Y., Zachariah, Sanoop, Malangoni, Mark, Kok KYY, Sharma R, Yoshiro Kobe, Moore E., Skrovina, Matej, Poiasina E., Zida M, Jovine E, Gupta S., Marwah, Sanjay, Poiasina, Elia, Díaz Nieto R, Leppaniemi A., Kenneth Yuh Yen Kok, Velmahos G., Khokha, Vladimir, Gomes CA, Ahmed, Adamu, Adesunkanmi A. R. K., Ashraf Abbas, Sakakushev B, Gonsaga RAT, Kenig J., Barnabé, Rita, Coimbra R., Sanjuan J., Sanjay Gupta, Ghnnam, Wagih, Sanjay Marwah, Abbas A, Tranà C, Coccolini F., Barnabe R., Junior G. A. P., Al Khalifa, Khalid, Naidoo, Noel, Gianluca Baiocchi, Tavares A., Victor Kong, Das, Koray, Bala, Miklosh, Kaoru Koike, Agresta F., Sanoop Zachariah, Ricardo Alessandro Teixeira Gonsaga, Moore, Ernest, Díaz-Nieto R, Moore E, Segovia Lohse, Helmut Alfredo, Naidoo N., Kuo-Ching Yuan, Rafael Díaz-Nieto, Ordonez C, Adamu Ahmed, Catena F., Kobe Y, Vettoretto N, AK Attri, Koray Das, Attri, AK, Ari Leppaniemi, Junior, Gerson Alves Pereira, Ishii, Wataru, Adesunkanmi, Abdul Rashid Kayode, Peev M. P., Yunfeng Cui, Kenig, Jakub, Gonsaga RA, Biffl, Walter, Siribumrungwong, Boonying, George Velmahos, Maurice Zida, Sharma R., Ahmed A, Mark Malangoni, Augustin G, Massimo Sartelli, Gonsaga R. A. T., Lohse HA, Murata K., Koike, Kaoru, Tavares A, Sartelli, Massimo, Coimbra, Raul, Hamedelneel AO, Hong SK, Ansaloni, Luca, Tavares, Alberto, Augustin G., Lohse H. A. S., Verni A, Miroslav P Peev, Coccolini, Federico, Guercioni G., Shoko T., Tranà, Cristian, Teixeira Gonsaga, Ricardo Alessandro, Gregorio Tugnoli, Gerych I, Sakakushev B., Koike K, Cui YF, Lohse HAS, Nereo Vettoretto, Sato, Norio, Yuan KC, Elio Jovine, Kok, Kenneth Yuh Yen, Massalou D., Irahara T, Ordonez C., Gonsaga, Ricardo Alessandro Teixeira, Attri, A. K., Damien Massalou, Bala M, Verni, Alfredo, El Zalabany T, Cui Y., Peev, Miroslav P., Gomes, Carlos Augusto, Ben-Ishay O., Adesunkanmi AR, Yuan K. -C., Goran Augustin, Zida, Maurice, Khokha V., Kobe, Yoshiro, Jakub Kenig, Guercioni, Gianluca, Kiyoshi Murata, Vettoretto N., Cui Y, Khokha V, Cristian Tranà, Sato N., Kong V, Gomes C. A., Ishii W, Leppaniemi, Ari, Malangoni M, Marwah S., Kluger, Yoram, Agresta, Ferdinando, 이재길, Naidoo N, Sharma, Rajeev, Vladimir Khokha, Ghnnam W, Noel Naidoo, Junior GA, Balogh Z., Abdul Rashid Kayode Adesunkanmi, Koike K., Gianluca Guercioni, Lee, Jae Gil, Matej Skrovina, Vettoretto, Nereo, Lohse, Helmut Alfredo Segovia, Barnabé R, Balogh, Zsolt, Jarry J, Alain Chichom Mefire, Peev, Miroslav V., Leppaniemi A, Catena, Fausto, Hamedelneel A. O., Raul Coimbra, Verni A., Lohsiriwat, Varut, Zachariah S., Das K., Coccolini F, Jarry, Julien, Hamedelneel, Ahmed O., Khalifa KA, Cino Bendinelli, Cui, Yunfeng, Murata K, Coimbra R, Tugnoli, Georgio, Poiasina E, Sakakushev, Boris, Das K, Federico Coccolini, Alfredo Verni, Lee J. G., Mefire A. C., Diaz-Nieto R., Ben-Ishay O, Murata, Kiyoshi, Al Khalifa K, Shoko, Tomohisa, Adesunkanmi ARK, Ihor Gerych, Jarry J., Chichom Mefire, Alain, Attri A. K., Ben-Ishay, Offir, Zida M., Baiocchi G., Yoram Kluger, Tugnoli, Gregorio, Díaz-Nieto, Rafael, Abbas, Ashraf, Hong S. -K., Catena F, Ghnnam W., Takayuki Irahara, Tamer El Zalabany, Baiocchi G, Kenig J, Ansaloni L., El Zalabany, Tamer, Tugnoli G., Bala M., Lohsiriwat V., Khalid Al Khalifa, Peev, Miroslav P, Fausto Catena, Miklosh Bala, Julien Jarry +318 morecore +1 more sourceDIXDC1 Promotes Lymphatic Metastasis and Resistance to Cuproptosis in Bladder Cancer Through Mediating DLAT
Advanced Science, EarlyView.DIXDC1 drives bladder cancer progression by binding and stabilizing DLAT. This axis enhances NEK7 and CCNE2 mRNA stability to promote proliferation and lymphatic metastasis, while limiting copper‐induced DLAT oligomerization to reduce cuproptosis sensitivity, identifying DIXDC1 as a potential target linking metastasis with cuproptosis resistance ...Hongqiong Li, Liang Cheng, Xiaole Lu, Haonan Dong, Shi Fu, Hongjin Shi, Mingsheng Liu, Chenwei Yang, Yuhang Huang, Zehua Chen, Yawei Zhang, Kaiwen Jie, Xiaoyue Zhang, Xiang Kui, Xinni Ye, Siting Chen, Xu Chen, Haifeng Wang +17 morewiley +1 more source
