Results 91 to 100 of about 149,144 (263)

CCDC80 Protects against Aortic Dissection and Rupture by Maintaining the Contractile Smooth Muscle Cell Phenotype

Advanced Science, EarlyView.
Aortic dissection (AD) is accompanied by a decrease in CCDC80 in vascular smooth muscle cells (VSMCs). CCDC80 can interact with JAK2, and VSMC‐specific CCDC80 deficiency accelerates the progression of AD by activating the JAK2/STAT3 pathway involved in regulating the phenotype switching and function of VSMCs.
Qingqing Xiao, Yi Li, Bin Cai, Xiying Huang, Liang Fang, Feng Liang, Long Chen, Ke Xu, Weifeng Zhang, Xiaolei Wang, Anwen Yin, Xia Wang, Zhaohua Cai, Fei Zhuang, Qin Shao, Bin Zhou, Berthold Hocher, Ben He, Linghong Shen   +18 more
wiley   +1 more source

Mechanical Stress Induced NOX2 Promotes Endothelial Dysfunction in Ventilator‐Induced Lung Injury: Potential Treatment with Quercetin

Advanced Science, EarlyView.
Abnormal mechanical stretch induced by mechanical ventilation (MV) disrupts endothelial junctions via the NOX2/ROS/CaMKII/ERK1/2 axis both in human aortic endothelial cells (HAECs) in vitro and in ventilator‐induced lung injury (VILI) in mice. Quercetin, an antioxidant predicted to bind to NOX2, can effectively prevent mechanical stretch‐induced ...
Tao Jiang, Yabing Zhang, Zhiye Guo, He Ren, Weiyi Hu, Qingping Yao, Yunlong Huo, Yingxin Qi, Kai Huang   +8 more
wiley   +1 more source

Glucose‐Responsive and Analgesic Gel for Diabetic Subcutaneous Abscess Treatment by Simultaneously Boosting Photodynamic Therapy and Relieving Hypoxia

Advanced Science, EarlyView.
The work constructs a glucose‐triggered gel for diabetic abscess treatment. The results demonstrate that the gel catalyzes glucose into oxygen, alleviates the hypoxia, and ensures sufficient ROS generation to combat pathogenic bacteria. Simultaneously, borneol within the gel can enhance the antibacterial activity of ROS and alleviate pain in patients ...
Bin Huang, Honglin An, Jianfeng Chu, Shiqi Ke, Jing Ke, Yiman Qiu, Jieping Zhang, Hanqi Zhu, Jiahui Lin, Minguang Yang, Dongliang Yang, Xuejiao Song, Weilin Liu   +12 more
wiley   +1 more source

Abdominal injuries [PDF]

Postgraduate Medical Journal, 1967
openaire   +2 more sources

SUMOylation is a Translatable Target in Hypoxic MNPs Regulating Retinal Vasculopathy

Advanced Science, EarlyView.
During ischemic retinopathy/retinal vasculopathy, UBC9‐mediated SUMOylation in retinal macrophages enhances their pro‐angiogenic capacity via hypoxia‐induced SUMOylation of FUS at K327/K502. This modification suppresses FUS binding to the Vegfa mRNA 3’UTR, stabilizing transcripts and facilitating VEGFA production. Targeting UBC9 inhibition can serve as
Zheng Zhong, Guangyu Liang, Huimin Yu, Jiaqi Li, Ruohong Wang, Xiaohong Ma, Ziqing Zhou, Yin Zhao, Fei Sun, Xufang Sun   +9 more
wiley   +1 more source

The treatment of penetrating wounds of the inferior vena cava [PDF]

, 1962
During the last 5 years, 10 gunshot and 2 stab wounds of the inferior vena cava have been treated, with 11 survivals and 1 death. The lacerations were above the renal veins in 4 cases and below in the others.
Beheler, EM, Freeark, RJ, Kaupp, HA, Starzl, TE   +3 more
core  

Inhibition of Heat Shock Protein 90β by Catalpol: A Potential Therapeutic Approach for Alleviating Inflammation‐Induced Cartilage Injuries in Osteoarthritis

Advanced Science, EarlyView.
The schematic diagram delineates the chondroprotective effects of Ca‐bMSN in OA models. The upper portion of the diagram depicts the synthesis process of Ca‐bMSN. The lower section illustrates the post‐injection of Ca‐bMSN in joint cavity, catalpol released and subsequently mediates the reduction of oxidative stress, ECM catabolism, apoptosis, and ...
Zhenwei Zhou, Binghua Zhang, Lang Liu, Jie Yang, Yuting Wang, Cheng Lv, He Zhang, Yuchi Wei, Zhanliang Jiang, Zeyu Peng, Daqing Zhao, Xiangyang Leng, Xiangyan Li, Hang Su, Haisi Dong   +14 more
wiley   +1 more source

Multi‐Omics and ‐Organ Insights into Energy Metabolic Adaptations in Early Sepsis Onset

Advanced Science, EarlyView.
This study shows that patients at risk of sepsis have a distinct metabolite and lipid signature, including serine and aminoadipic acid, in their serum before clinical diagnosis. A mouse model of sepsis with a compatible serum signature reveals underlying metabolic changes, including mitochondrial adaptation, altered serine‐dependent purine metabolism ...
Lin‐Lin Xu, Zhengyuan Zhou, Sascha Schäuble, Wolfgang Vivas, Karen Dlubatz, Michael Bauer, Sebastian Weis, Mervyn Singer, Roman Lukaszewski, Gianni Panagiotou   +9 more
wiley   +1 more source

Chinese Expert Consensus on Standardized Outpatient Management of Sarcopenia in the Elderly (2024)

AGING MEDICINE, EarlyView.
In China, specific sarcopenia clinics are not sufficient for outpatients. This consensus combines the professional advice of domestic geriatrics experts, summarizes the existing domestic experience in the establishment of sarcopenia clinics, and provides guidance for the management of sarcopenia clinics.
Zhang Qin, Kang Lin, Wang Jianye, Xi Huan, Yu Pulin, Zhang Cuntai, Hidenori Arai, Tuo Xiping, Yang Yunmei, Liu Xiaohong, Chen Chan, Chen Huaihong, Chen Xujiao, Cheng Lijuan, Deng Linzi, Ding Yi, Dong Birong, Dong Juan, Gao Yue, Gu Haifeng, Guo Yan, Han Hui, Hidenori Arai, Hu Fang, Shangcheng District, Hu Jian, Hu Yao‐min, Hu Yixin, Huang Gairong, Jian Zaijin, Jiang Wenjing, Kang Lin, Li Fuchao, Li Jian, Li Jing, Li Tianlang, Lin Fan, Liu Juan, Liu Xiaohong, Liu Xuejun, Lou Huiling, Luo Lan, Luo Man, Ma Lina, Mao Yongjun, Nie Jing, Ouyang Xiaojun, Qi Guoxian, Qiao Wei, Shi Hong, Tian Tao, Tuo Xiping, Wang Chaohui, Wang Jiaqiu, Wang Jianye, Wang Peng, Wang Quan, Wang Xiaonan, Wang Yuan, Wang Zhaodi, Wei Yanan, Wu Jun, Wu Shuhua, Wu Xiaohe, Xi Huan, Xin Xiaofeng, Xu Meiqun, Yang Yunmei, Yin Shi, Yu Plin, Zhang Cuntai, Zhang Qin, Zhang Xiaoyan, Zhang Ying, Zhao Xiaohong, Zhong Yuan, Zhou Baiyu, Zhou Houguang, Zhou Xiaohui   +78 more
wiley   +1 more source

Bowel preparation and surgical site infections in laparoscopic and robot‐assisted right‐sided colon cancer surgery with intracorporeal anastomosis: A retrospective study

Annals of Gastroenterological Surgery, EarlyView.
This retrospective study investigated risk factors for surgical site infections (SSIs) in right‐sided colon cancer surgeries using intracorporeal anastomosis (IA). The results demonstrated that preoperative oral antibiotics (OA) significantly reduced SSI rates, with OA identified as an independent protective factor, suggesting its beneficial role in ...
Naoya Ozawa, Tomohiro Yamaguchi, Takumi Kozu, Tatsuki Noguchi, Takashi Sakamoto, Shimpei Matsui, Toshiki Mukai, Takashi Akiyoshi, Yosuke Fukunaga   +8 more
wiley   +1 more source