Results 81 to 90 of about 85,709 (260)

Mucoadhesive Peptide‐Catalase Self‐Assembled Nano‐Formulation for Effective Treatment of Mucosal Inflammatory Diseases

open access: yesAdvanced Science, EarlyView.
CR8L10 is self‐assembled with catalase (CAT) to form CR8L10@CAT nanocomplexes, which can anchor to mucosal surfaces via thiol‐disulfide exchange with mucin, thereby enhancing their mucosal retention. The efficient reactive oxygen species (ROS) scavenging at inflamed sites would then result in successful treatment in both the intravesical IC/BPS model ...
Xinzhu Li   +13 more
wiley   +1 more source

­Musculoskeletal Injuries in Recreational Athletes as a Diagnostic Challenge in Acute Pain Syndromes – A Narrative Review

open access: yesJournal of Education, Health and Sport
Background. Musculoskeletal injuries are a common consequence of recreational physical activity. In some cases, they may present as acute pain syndromes with a non-specific clinical presentation that can mimic symptoms of internal diseases.
Sabina Ściążko-Gancarczyk   +4 more
doaj   +1 more source

Bioengineered Exosome‐Loaded Immunomodulatory Bioadhesive Spray Reverses Liver Fibrosis and Metabolic Dysfunction That Triggers Beneficial Gut‐Liver Crosstalk in Chronic Fatty Liver Disease

open access: yesAdvanced Science, EarlyView.
Umbilical cord stem cell‐derived exosomes encapsulated in an immunomodulatory bioadhesive hydrogel spray enable localized therapy, sustained vesicle delivery, macrophage polarization, suppress systemic inflammation, and mitigate glucose and insulin homeostasis impairments in MAFLD.
Triya Saha   +4 more
wiley   +1 more source

CXCL10/SLC11A1 Axis Exacerbates Septic Liver Injury by Regulating Neutrophil Extracellular Traps Formation to Drive Macrophage Pro‑Inflammatory Polarization

open access: yesAdvanced Science, EarlyView.
In sepsis‐induced liver injury, marked neutrophil infiltration correlates with disease severity. Neutrophil SLC11A1 drives intracellular Fe2+ and ROS via the Fenton reaction, promoting NETs formation. Hepatocyte‐derived CXCL10 recruits neutrophils and activates the JAK/STAT1/SLC11A1 axis, enhancing NETs‐mediated inflammation.
Haiping Lin   +8 more
wiley   +1 more source

Extrahepatic bile ducts injury: a report on 14 cases

open access: yesSão Paulo Medical Journal
Traumatic injuries of the extrahepatic biliary tract are infrequent, occurring in approximately 0.5 % of all patients with blunt and penetrating abdominal trauma. The incidence of this injury due to blunt abdominal trauma is rare.
Luiz Fernando Correa Zantut   +4 more
doaj   +1 more source

Introducing Borsantrazole: A Trifunctional Boron‐Based Pyrazole That Extends the Lifespan of Amyotrophic Lateral Sclerosis Mice

open access: yesAdvanced Science, EarlyView.
Herein we report a boron‐based pyrazole, (Borsantrazole ‐ a small molecule that selectively targets oxidative stress) that significantly increases survival, reduces weight loss, delays disease onset, and affects global protein changes in the SOD1‐G37R mouse model of ALS.
Nitesh Sanghai   +9 more
wiley   +1 more source

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