Results 61 to 70 of about 85,709 (260)

BIN1 and ALDH1B1 Deficiency in Colonic Smooth Muscle Drives Mitochondrial Dysfunction and Fibrosis in Slow‐Transit Constipation

Advanced Science, EarlyView.
Slow‐transit constipation (STC) is a disabling motility disorder with unclear smooth‐muscle mechanisms. Spatial proteomic analysis of STC patient colon reveals both the central pathogenic role of smooth muscle cells (SMCs) in STC and novel regulators of intestinal motility, BIN1 and ALDH1B1.
Jianbo Liu, Hao Zhang, Wenhao Qiao, Ran Liu, Jie Sun, Xiaopei Li, Qin Li, Dongbo Zhao, Dawei Chen, Jingxin Li, Shuxiao Dong   +10 more
wiley   +1 more source

Multidimensional and Multifunctional Laser‐Induced Graphene (LIG) for Point‐of‐Care and Wearable Biosensing, Theranostics, and Bioactive Interfaces Toward Personalized Healthcare and Regenerative Medicine

Advanced Science, EarlyView.
Multidimensional laser‐induced graphene (LIG) spanning from 0D to 3D architectures is comprehensively reviewed for multifunctional biomedical platforms, including biosensing, theranostics, and bioactive interface applications, which highlights its potentials for point‐of‐care diagnostics, wearable health monitoring, smart drug delivery, and tissue ...
Li Zhang, Yurou Yuan, Xiaohong Ding, Wing Cheung Mak   +3 more
wiley   +1 more source

Correlation between Rib Fractures and Intra-abdominal Organ Injuries after Blunt Chest Trauma.

Albanian Journal of Trauma and Emergency Surgery, 2020
Introduction; The most common thoracic injuries were rib fractures (40%) and simple lung contusions (35%) and the abdominal organs most commonly injured were the spleen (35%), liver (25%), and kidney (20%). Mortality varies from 3-22%.
Agron DOGJANI, Kastriot HAXHIREXHA, Henri KOLANI, Edvin SELMANI, Arben GJATA, Melita TODAJ, Artiola TODAJ, Hysni BENDO   +7 more
doaj  

Herba Lysimachiae Polysaccharide‐Modified Selenium Nanoparticles Alleviate Oxidative Injury in Kidney Stones via TOMM22‐Regulated Mitophagy Activation

Advanced Science, EarlyView.
HLP‐SeNPs, a Lysimachia christinae polysaccharide‐modified selenium nanoparticle, treat kidney stones by downregulating TOMM22 expression, which reduces PINK1 translocation into mitochondria and promotes its retention on the outer mitochondrial membrane.
Junyi Yang, Guoruiyu Lyu, Wenlong Wan, Dongfeng Yuan, Jiabo Li, Yongqi Wang, Baokang Wang, Zhilong Ma, Yuanyuan Yang, Yang Xun, Xiao Yu   +10 more
wiley   +1 more source

SURGICAL TREATMENT OF ABDOMINAL INJURIES WITH COMBINED TRAUMA AND POLYTRAUMA: A COMPARATIVE ANALYSIS OF THE STRUCTURE AND COMPONENTS OF THE ABDOMINAL INTERVENTION PHASE (MESSAGE TWO)

Клінічна та профілактична медицина
Introduction. Blunt abdominal trauma is recognized as one of the leading causes of preventable death among people of working age. In Ukraine, the system of anatomical and functional prediction of the course of trauma, which determines the time, volume ...
Serhii I. Panasenko, Serhii O. Guriev, Volodymyr V. Nehoduiko, Nizar R. Kerbazh   +3 more
doaj   +1 more source

Isolated traumatic rupture of the gallbladder

Radiology Case Reports, 2015
Gallbladder injury resulting from blunt abdominal trauma is rare, being found in only about 2% of patients who undergo laparotomy for abdominal trauma. Its small size and anatomic location—partially embedded in the liver tissue, surrounded by the omentum
Benjamin Yin Ming Kwan, MD, Paul Plantinga, BSc(H), MD, Ian Ross, BSc, MD, FRCPC   +2 more
doaj   +1 more source

A Multimodal Magnetically Driven Soft Robot With Integrated Actuation‐Sensing Based on Photothermal Reprogramming Technology

Advanced Science, EarlyView.
This work reports a thermally safe, photothermally reprogrammable magnetic soft robot with its reprogramming temperature tuned to ∼39.5°C for biocompatibility. It achieves multimodal locomotion (max speed of 1.8 BL/s) and integrates liquid‐metal capacitive sensing to monitor self‐motion and detect environmental changes in simulated gastric environments,
Liu Yang, Yuliao Dong, Kangning Li, Cheng Jing, Ben Wang, Lin Xu   +5 more
wiley   +1 more source

Engineered Exosomal miR‐146a‐5p Reprograms BMSC Fate and Restores Mitochondrial Homeostasis in Glucocorticoid‐Induced Osteonecrosis of Femoral Head

Advanced Science, EarlyView.
Exosomal miR‐146a‐5p is identified as a pivotal regulator in steroid‐induced osteonecrosis. Its reduction activates NF‐κB signaling, compromises mitophagy, and disrupts mitochondrial bioenergetics, resulting in autophagic disequilibrium. Engineered exosomes delivering miR‐146a‐5p reinstate mitochondrial function, augment oxidative phosphorylation and ...
Zehui Lv, Xuejie Cai, Yiming Xu, Xingdong Yang, Ruoying Wang, Han Wang, Yixin Bian, Jiawei Xu, Jiao Lu, Lulu Liu, Yingjie Wang, Jibin Song, Bin Feng, Xisheng Weng   +13 more
wiley   +1 more source

Pattern of Abdominal Organ Injuries in Road Traffic Accidents: An Autopsy Based Cross-sectional Study from Central Kerala, India [PDF]

Journal of Clinical and Diagnostic Research
Introduction: The abdominal wall usually avoids severe damage by transferring stress to the abdominal organs. Analysing the pattern of abdominal injuries in Road Traffic Accidents (RTAs) may help clinicians in providing more targeted treatment to
Joseph Ajin, Baby Neeraja, Rajan Boney, Neeratty Asokan Balaram, Babu Boban   +4 more
doaj   +1 more source

Intrinsically Mitochondria‐Targeting Nanozyme via Coordination‐Assembly of Natural Quercetin for Cascade Antioxidant Therapy of Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
This study uncovers that quercetin naturally targets mitochondria. By coordinating quercetin with Fe3+, we engineer an ultrasmall cascade nanozyme (MCN) with superoxide dismutase‐catalase activities. MCN crosses the damaged blood–brain barrier, scavenges mitochondrial ROS, prevents mitochondrial DNA leakage, and blocks the cGAS‐STING pathway, thereby ...
Wenxuan Zheng, Zhicheng Wang, Xin Zhou, Shuya Wang, Xiaojing Shi, Tingli Xiong, Ruishi Li, Yuting Lin, Zhen Chen, Jiawen Wei, Fei Li, Jinwen Ge, Kelong Ai, Chong Liu, Guiming Deng   +14 more
wiley   +1 more source