Results 101 to 110 of about 316,094 (303)

Adipose tissue NAD+-homeostasis, sirtuins and poly(ADP-ribose) polymerases -important players in mitochondrial metabolism and metabolic health

Redox Biology, 2017
Obesity, a chronic state of energy overload, is characterized by adipose tissue dysfunction that is considered to be the major driver for obesity associated metabolic complications.
Riikka Jokinen, Sini Pirnes-Karhu, Kirsi H. Pietiläinen, Eija Pirinen   +3 more
doaj   +1 more source

Sarcopenic obesity and risk of cardiovascular disease and mortality: a population-based cohort study of older men. [PDF]

, 2014
OBJECTIVES: To examine associations between sarcopenia, obesity, and sarcopenic obesity and risk of cardiovascular disease (CVD) and all-cause mortality in older men. DESIGN: Prospective cohort study.
Atkins, JL, Lennon, LT, Morris, RW, Papacosta, O, Wannamethee, SG, Whincup, PH   +5 more
core   +1 more source

Comparative efficacy of GLP‐1 RA, tirzepatide and SGLT‐2 inhibitors in metabolic liver disease: A network meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Aim Metabolic liver disease, including nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis, is a major cause of chronic liver dysfunction worldwide, creating an urgent need for effective treatments. This systematic literature review (SLR) and network meta‐analysis (NMA) systematically reviews and compares the efficacy and safety ...
Andrej Belančić, Christina Antza, Anastasios Poutachidis, Smaro Palaska, Elvira Meni Maria Gkrinia, Andrea Katrin Faour, Yusuf Ziya Sener, Seher Sener, Rehena Sultana   +8 more
wiley   +1 more source

Obesity, fat distribution, and risk of frailty in two population-based cohorts of older adults in Spain [PDF]

, 2015
OBJECTIVE: To evaluate for the first time the longitudinal relationship between abdominal obesity and the onset of frailty. METHODS: Study based on results from two population-based cohorts, the Seniors-ENRICA, with 1801 individuals aged ≥60, and the ...
Barzilay, Blaum, Bouchard, Brown, Bryant, Choi, Clegg, Cooper, DerSimonian, Fried, Garcia-Garcia, García-García, Guralnik, Hardy, Hubbard, Hulens, Jensen, Kahn, Kuo, León-Muñoz, Manini, Marcus, Meeuwsen, Ng, Ottenbacher, Pasco, Ritz, Rodríguez-Artalejo, Santanasto, Smit, Stenholm, Stenholm, Sternfeld, Strandberg, Tucker, Villareal, Washburn, Woo, Woods   +38 more
core   +2 more sources

Anti‐Obesity Pharmacotherapy and Emerging Multimodal Interventions for Obstructive Sleep Apnea

Chronic Diseases and Translational Medicine, EarlyView.
Cellular and molecular mechanisms of obesity‐related obstructive sleep apnea (OSA). ADMA: asymmetric dimethyrarginine, NLRP3: nucleotide‐binding domain, leucine‐rich repeat family, Pyrin domain containing 3, TLR: toll‐like receptors, IL‐1β: interleukin‐1β, IL‐6: interleukin‐6; LPS: lipopolysacharide, ROS: reactive oxygen species, TNF‐α.
Anish Preshy, Cornelius J. Fernandez, Mohammad Hamid Nedai, Joseph M. Pappachan   +3 more
wiley   +1 more source

Body composition and body fat distribution are related to cardiac autonomic control in non-alcoholic fatty liver disease patients [PDF]

, 2013
BACKGROUND/OBJECTIVES: Heart rate recovery (HRR), a cardiac autonomic control marker, was shown to be related to body composition (BC), yet this was not tested in non-alcoholic fatty liver disease (NAFLD) patients.
B Fernhall, C Panzer, CR Cole, DD Christou, DM Hadley, DP Vivekananthan, E Bertin, E Savgan-Gurol, EG Kamel, EO Nishime, ET Howley, F Kreier, G Nilsson, G Targher, GA Bray, H Cortez-Pinto, H Cortez-Pinto, H Nomura, H Santa-Clara, IJ Ketel, J Cohen, J Myers, J Silva-Nunes, JD Browning, JF Horowitz, JM Clark, K Imai, K Shetler, KM Chacko, L B Sardinha, LA Diaz, LR Davrath, M Cote, M da Lapa Rosado, M Gnacinska, M Lafontan, MA Kizilbash, MB Snijder, MJ Lipinski, MK Kim, MR Carnethon, MR Carnethon, MR Esco, MS Chen, N M Pimenta, NM Pimenta, P Angulo, P J Sousa, R Arena, R Calé, RA Bruce, RS Rector, S Bellentani, TA Hargens, TG Lohman, TJ Bartness, X Melo, YJ Cheng, YW Park   +58 more
core   +1 more source

Pancreatic Adenocarcinoma: Diagnosis by Ultrasound‐Guided Fine‐Needle Aspiration—Cyto‐Histological Correlation and Experience at a Multidisciplinary Tertiary Reference Center

Diagnostic Cytopathology, EarlyView.
ABSTRACT Background Pancreatic adenocarcinoma (PDAC) is characterized by its poor prognosis. Cytology is essential for diagnostic confirmation and ancillary studies. The endoscopic ultrasound (EUS) set a precedent, facilitating cytological sampling through fine‐needle aspiration (FNA), with a sensitivity of 93% and a specificity of 95%.
Judith González‐López, Mónica Elizabeth Bauza, Judith Pérez‐Rojas, Cecilia López‐Valdivia, Carlos Zac Romero, Óscar Castells‐Perona, Cristina Ballester‐Ibáñez, Eva Montalvá‐Orón, Rafael López‐Andújar, Lidia Argüello‐Viudez, Mireya Prieto Rodríguez   +10 more
wiley   +1 more source

An Obesity Dietary Quality Index Predicts Abdominal Obesity in Women: Potential Opportunity for New Prevention and Treatment Paradigms

Journal of Obesity, 2010
Background. Links between dietary quality and abdominal obesity are poorly understood. Objective. To examine the association between an obesity-specific dietary quality index and abdominal obesity risk in women. Methods.
Dolores M. Wolongevicz, Lei Zhu, Michael J. Pencina, Ruth W. Kimokoti, P. K. Newby, Ralph B. D'Agostino, Barbara E. Millen   +6 more
doaj   +1 more source

Prevalence and Associated Factors of Hypertension Among Civil Servants Working in Arba Minch Town, South Ethiopia [PDF]

, 2016
Despite Hypertension is a global public health challenge and a leading modifiable risk factor for cardiovascular disease and death attention was not given in developing countries.
Ayele, G. (Gistane), Girum, T. (Tadele), Kalssa, A. (Aschenaki), Tamiso, A. (Alemu)   +3 more
core   +2 more sources

Pss knockdown in the midgut causes growth retardation in Drosophila similar to that in human LMHD

Developmental Dynamics, EarlyView.
Abstract Background Phosphatidylserine synthase (PSS), localized in the mitochondrial membrane, synthesizes phosphatidylserine. In humans, mutations in Pss lead to Lenz–Majewski hyperostotic dwarfism, a disorder affecting growth and development. The effects of Pss mutations on the growth of Drosophila melanogaster are not fully known. Hence, this study
Kwan‐Young Kim, You‐Lim Hwang, Sunwoo Yeom, Seung‐Hae Kwon, Sang‐Hak Jeon   +4 more
wiley   +1 more source