Results 61 to 70 of about 603,309 (249)

Beyond Biomimetics: Pathology‐Informed Engineering Rescues Reconstituted HDL From Inflammatory Dysfunction for Sepsis Immunotherapy

Advanced Science, EarlyView.
A pathology‐informed engineering strategy rescues reconstituted HDL from inflammatory dysfunction in sepsis. By integrating a ceria nanozyme‐celastrol coordination complex, the platform preserves HDL structure and endotoxin handling, sustains hierarchical intracellular delivery, and enhances immunoregulation across pathological models, translating ...
Han Zhou, Lei Zhang, Xingyu Cai, Jiajia Su, Guangyu Dai, Xue Chen, Hanming Wang, Jia Hua, Jianping Liu, Chunmeng Sun, Xiancheng Chen, Erhao Wang, Wenli Zhang   +12 more
wiley   +1 more source

HISTOPATHOLOGICAL STUDY OF SEPSIS EXPERIMENTALLY INDUCED BY CECAL LIGATION AND PUNCTURE IN RATS [PDF]

Basrah Journal of Veterinary Research, 2013
Sepsis is a syndrome involving the systemic host response to an inflammatory or infectious agents.itis a common and frequently fatal condition that occur as a result of severe infection often leading to overwhelming systemicinflammation (1 , 2) , Also ...
A. M. Al-Saidya H. Kh. Ismail
doaj   +1 more source

Estudo comparativo da celularidade da reação inflamatória aguda na serosa e mesentério intestinais às telas de poliamida e polipropileno em ratos wistar com peritonite fecal por técnica morfométrica [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-graduação em Ciências Médicas, Florianópolis, 2004A peritoneostomia é um recurso tático na condução de pacientes com peritonite aguda grave e ...
Russi, Ricardo Fantazzini
core  

LAPTM5 Downregulation‐Driven VAMP8 Phosphorylation Impairs Autophagosome‐Lysosome Fusion and Aggravates Septic Acute Lung Injury

Advanced Science, EarlyView.
LAPTM5 functions as a critical molecular scaffold bridging PGAM5 and VAMP to facilitate PGAM5‐mediated dephosphorylation of VAMP8. This cascade promotes autophagosome‐lysosome fusion, restores impaired autophagic flux, and clears damaged mitochondria, thereby mitigating cellular oxidative stress and systemic inflammation.
Lang Jiang, Qilan Li, Hao Liu, Xuehui Gao, Hongyu Nie, Lang Chen, Mei He, Xuefeng Li, Xiangming Fang, Jiqian Xu, Hao Zhang, Jiahong Xia, You Shang   +12 more
wiley   +1 more source

Selective Hemosorption of Endotoxin in the Treatment of Abdominal Sepsis

Общая реаниматология, 2009
Sepsis remains to be one of the most urgent problems of modern medicine, which are associated with a steadily high mortality (as high as 70%). The central point of the pathogenesis of abdominal pathogenesis is the translocation of the gram-negative flora
S. Ye. Khoroshilov, N. A. Karpun, S. G. Polovnikov, A. V. Nikulin, A. N. Kuzovlev   +4 more
doaj   +1 more source

National Sepsis Report 2016 [PDF]

, 2017
In 2016, the definition of sepsis was changed from a clinical syndrome defined by a systemic inflammatory response (SIRS) due to infection to a life-threatening organ dysfunction caused by a dysregulated immune response to infection (formerly severe ...
National Sepsis Programme.
core   +1 more source

NCOA4 Accelerates Abdominal Aortic Aneurysm Formation by Regulating Macrophage Activation and Ferroptosis via STAT1–CH25H Axis

Advanced Science, EarlyView.
Under pathological stimulation, NCOA4 in macrophages interacts with STAT1 to promote CH25H transcription. The subsequent increase in 25‐HC production activates macrophages, triggers inflammatory responses and ferroptosis, and accelerates the progression of AAA.
Zhinan Wu, Yuxuan Qian, Wenyi Xu, Fei Liao, Xueliang Liu, Xiao Kuang, Guqing Luo, Xinjie He, Lixian Jiang, Song Ding   +9 more
wiley   +1 more source

Determinação do GL50 em dois modelos de sepse experimental [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Ciências Médicas, Florianópolis, 2012INTRODUÇÃO Ainda não foi descrito um modelo experimental ideal de para estudo da sepse.
Locks, Giovani de Figueiredo
core  

Randomized double-blind placebo-controlled trial of 40 mg/day of atorvastatin in reducing the severity of sepsis in ward patients (ASEPSIS Trial) [PDF]

, 2012
Introduction: Several observational studies suggest that statins modulate the pathophysiology of sepsis and may prevent its progression. The aim of this study was to determine if the acute administration of atorvastatin reduces sepsis progression in ...
Matthew W Cooke, Patel, Jaimin M, Thickett, David R, David R Thickett, Alan Jones, Anthony H Barnett, Hawkey, P. M., Jaimin M Patel, Catherine Snaith, Perkins, Gavin D., Smith, F. Gao, Jones, Alan, Gao Smith, Fang; id_orcid, Fang Gao, Linhartova, Lucie, Snaith, Catherine, Hong, Tan, Gao, Fang, Tan Hong, Lucie Linhartova, Hawkey, Peter, Peter Hawkey, Cooke, Matthew W, Thickett, David R; id_orcid, Barnett, Anthony H, Cooke, Matthew, Barnett, A. H., Gavin D Perkins, Melody, Teresa, Perkins, Gavin D, Patel, Jaimin M., Thickett, David R., Teresa Melody   +32 more
core   +1 more source

Comparison of Minimally Invasive Colectomy Between Intra‐ Versus Extra‐Corporeal Anastomosis Technique (COMMIT Study): Short‐Term Analysis

Annals of Gastroenterological Surgery, EarlyView.
This multicenter propensity score‐matched study of 3213 patients compared intracorporeal (IA) and extracorporeal (EA) anastomosis during minimally invasive colectomy. IA was associated with a significantly lower incidence of intraoperative blood loss ≥ 200 mL (2.5% vs.
Takuya Takami, Takehito Yamamoto, Yoshiro Itatani, Ryosuke Mizuno, Kae Okoshi, Yasunori Deguchi, Keiji Nagata, Tomoaki Okada, Rei Mizuno, Kazutaka Obama   +9 more
wiley   +1 more source