Results 1 to 10 of about 751 (114)

Identification of the main flavonoids of Abelmoschus manihot (L.) medik and their metabolites in the treatment of diabetic nephropathy [PDF]

Frontiers in Pharmacology, 2023
Introduction: Huangkui capsule (HKC) is made from the ethanol extract of Abelmoschus manihot (L.) Medik [Malvaceae; abelmoschi corolla] and received approval from the China Food and Drug Administration (Z19990040) in 1999.
Haitao Ge, Yu Hongmei, Sun Jianguo
exaly   +4 more sources

The pharmacological mechanism of Abelmoschus manihot in the treatment of chronic kidney disease [PDF]

Heliyon, 2023
Abelmoschus manihot (A.manihot) is a herbaceous flowering medicinal plant and flavonoids are its main pharmacological active ingredients. A.manihot is listed in the 2020 edition of the Chinese Pharmacopoeia for the treatment of chronic kidney disease ...
Cuiting Wei, Chao Wang, Run Li, Yunfeng Bai, Xue Wang, Qingyun Fang, Xiangmei Chen, Ping Li   +7 more
exaly   +4 more sources

Integrative physiological, transcriptomic, and metabolomic analysis of Abelmoschus manihot in response to Cd toxicity [PDF]

Frontiers in Plant Science
Rapid industrialization and urbanization have caused severe soil contamination with cadmium (Cd) necessitating effective remediation strategies. Phytoremediation is a widely adopted technology for remediating Cd-contaminated soil.
Mengxi Wu
exaly   +4 more sources

Effects of Abelmoschus manihot (L.) and its combination with irbesartan in the treatment of diabetic nephropathy via the gut–kidney axis [PDF]

Frontiers in Pharmacology
BackgroundClinical observations have recently shown that Abelmoschus manihot (L.) in the form of Huangkui capsule (HKC) and in combination with irbesartan (EB) is an effective therapy for diabetic nephropathy (DN) in patients with type 2 diabetes (T2D ...
Haitao Ge, Yu Hongmei, Ge Haitao
exaly   +4 more sources

Abelmoschus manihot alleviates insulin resistance in diabetic kidney disease through attenuation of inflammation [PDF]

BMC Nephrology
Background Emerging evidence implicates insulin resestance (IR) and chronic inflammation as interdependent drivers of diabetic kidney disease (DKD) progression.
Xiansen Wei, Shimin Jiang, Jiao Zhang, Xia Gu, Hongmei Gao, Jian Lu, Wenge Li   +6 more
doaj   +2 more sources

Transcriptome and Metabolome Analysis Reveal the Flavonoid Biosynthesis Mechanism of Abelmoschus manihot L. at Different Anthesis Stages [PDF]

Metabolites, 2023
Abelmoschus manihot L. (HSK) is a rare and endangered species in the wild that grows on the cliffs of deep mountains. As a natural plant, the chemical composition of HSK is relatively complex, which mainly includes flavonoids, organic acids ...
Jiaqi Hou, Yuhan Zhou, Liping Ran, Yanzhu Chen, Ting Zhang, Bowei Sun, Yimo Yang, Qianzi Sang, Li Cao   +8 more
doaj   +2 more sources

Single-cell spatial transcriptomics reveals potential molecular mechanisms of <i>Abelmoschus manihot</i> (L.) medic in treating diabetic kidney disease. [PDF]

Imeta
A clinical study reported that Abelmoschus manihot (L.) Medic (A. manihot), in the form of Huangkui capsule (HKC), combined with irbesartan (IRB) is an effective therapy for patients with diabetic kidney disease (DKD). The bioactive components of HKC are total flavones extracted from A. manihot (TFA).
Wu C, Tang H, Yu Y, Song Y, Ge H, Shen Y, Wu J, Gu HF.   +7 more
europepmc   +2 more sources

Total flavone of Abelmoschus Manihot improves colitis by promoting the growth of Akkermansia in mice [PDF]

Scientific Reports, 2021
The total flavone of Abelmoschus manihot (TFA), a compound extracted from the flowers of Abelmoschus manihot (L.) Medic, has been widely used for the treatment of Crohn's disease, chronic glomerulonephritis and other diseases.
Fan Bu, Yang Ding, Tuo Chen, Qiong Wang, Rong Wang, Jin-yong Zhou, Feng Jiang, Dan Zhang, Minmin Xu, Guoping Shi, Yugen Chen   +10 more
doaj   +2 more sources

Screening and validation of optimal real-time PCR reference genes for Abelmoschus Manihot [PDF]

Scientific Reports
Abelmoschus Manihot is an important medicinal and edible plant known for its functional secondary metabolites. However, little is known about the key genes involved in production of secondary metabolites in A. manihot.
Qixuan Wu, Meixin Deng, Xiaolan Zhao, Jianmei Long, Jianxia Zhang   +4 more
doaj   +2 more sources

Abelmoschus Manihot flowers inhibit dysbiotic Enterobacteriaceae expansion by promoting Clostridium bolteae-mediated hypoxia restoration [PDF]

Microbiome
Background Inflammatory bowel disease (IBD) is a chronic inflammatory disease that has become prevalent worldwide. Excessive expansion of Enterobacteriaceae is a key feature of dysbiosis in IBD patients, which further exacerbates intestinal inflammation.
Chengxi Li, Yumeng Wang, Qinyu Zhang, Huashi Liang, Jianping Li, Shu Zhang, Jinao Duan, Jianming Guo   +7 more
doaj   +2 more sources