Results 21 to 30 of about 92 (58)
Anti-topoisomerase drugs as potent inducers of chromosomal aberrations
Genetics and Molecular Biology, 2000 DNA topoisomerases catalyze topological changes in DNA that are essential for normal cell cycle progression and therefore they are a preferential target for the development of anticancer drugs.
Loredana Bassi, Fabrizio Palitti
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Associação na mesma família das doenças de Charcot-Marie-Tooth e de Friedreich
Arquivos de Neuro-Psiquiatria, 1972 Quatro irmãos com moléstias de Charcot-Marie-Tooth são estudados do ponto de vista clínico e genético. São ressaltadas, mediante análise da sintomatologia, as formas de transição no grande grupo de moléstias heredodegenerativas, sendo atribuída ...
Charles Peter Tilbery +3 more
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Chromosome damage induced by DNA topoisomerase II inhibitors combined with g-radiation in vitro
Genetics and Molecular Biology, 1998 Combined radiation and antineoplastic drug treatment have important applications in cancer therapy. In the present work, an evaluation was made of two known topoisomerase II inhibitors, doxorubicin (DXR) and mitoxantrone (MXN), with g-radiation.
Maria Cristina P. Araújo +4 more
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Genetics and Molecular Biology, 1999 The effect of butylated hydroxytoluene (BHT), a widely used food additive, on chromosomal alterations induced by cadmium chloride (CC) and potassium dichromate (PD) in Chinese hamster ovary (CHO) cells was studied both at metaphase and anaphase-telophase.
Claudia A. Grillo +2 more
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Hansenologia Internationalis, 1978 As linhas de pesquisa que foram exploradas para avaliar a importância da constituição genética humana na determinação da resistência e suscetibilidade ao Mycobacterium leprae foram revistas no presente trabalho.
BERNARDO BEIGUELMAN
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Prevalência das malformações congênitas identificadas em fetos com trissomia dos cromossomos 13, 18 e 21 [PDF]
Revista Brasileira de Ginecologia e Obstetrícia, 2015 OBJETIVO: Descrever a prevalência das malformações encontradas nos fetos com trissomia dos cromossomos 13, 18 e 21, identificando as mais frequentes em cada condição.
Caroline Soares Cristofari Emer +6 more
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Revista Brasileira de Cancerologia, 2023 Enfermeiras, atendentes e assistentes de enfermagem que preparam e aplicam antineoplásicos em unidades hospitalares apresentaram freqüências aumentadas de anomalias e de trocas entre cromátides-irmãs (TCI) em cromossomos de linfócitos periféricos.
Eny Maria Goloni-Bertollo +2 more
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Genotoxic action of the sesquiterpene lactone glaucolide B on mammalian cells in vitro and in vivo
Genetics and Molecular Biology, 1999 Glaucolide B is a sesquiterpene lactone isolated from Vernonia eremophila Mart. (Vernonieae, Asteraceae) and has schistosomicidal, antimicrobial and analgesic activities.
Regislaine V. Burim +3 more
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Clonal chromosome abnormalites found in three non-neoplastic proliferative brain lesions
Genetics and Molecular Biology, 1999 Chromosome analysis was made of brain lesions from three patients which, according to classical histopathological criteria, did not contain tumor cells.
Cláudia Aparecida Rainho +3 more
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Cadernos de Saúde Pública, 1998 Pesticides can cause gene mutations and chromosomal aberrations in exposed individuals. We have investigated 24 workers exposed to pesticides. Clinical examinations and cytogenetic and toxicological tests were performed.
Salete Marcia Bréga +6 more
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