Results 271 to 280 of about 64,155 (301)

[Hematological malignancies driven by aberrant splicing].

[Rinsho ketsueki] The Japanese journal of clinical hematology, 2023
The process of RNA splicing plays a pivotal role in gene expression and genetic information modification by converting pre-mRNA into mature mRNA. Dysregulation of this process has been associated with aberrant gene expression and function, leading to hematopoietic malignancies. Through recent clinical and mouse model analyses, insights have been gained
Weijia, Zang, Wataru, Saika, Yumi, Aoyama, Daichi, Inoue   +3 more
openaire   +1 more source

Aberrant and alternative splicing in skeletal system disease

Gene, 2013
The main function of skeletal system is to support the body and help movement. A variety of factors can lead to skeletal system disease, including age, exercise, and of course genetic makeup and expression. Pre-mRNA splicing plays a crucial role in gene expression, by creating multiple protein variants with different biological functions.
Xin, Fan, Liling, Tang
openaire   +2 more sources

Targeting aberrant splicing

Nature Reviews Cancer, 2023
openaire   +2 more sources

Aberrant splice variants to understand ccRCC

Nature Reviews Urology, 2022
openaire   +2 more sources

Aberrant alternative splicing in cancer: Splicing events and their regulatory mechanisms (Review)

International Journal of Oncology
Alternative RNA splicing provides cells with transcriptomic and proteomic diversity by adding another layer of regulation to gene expression. Accumulating evidence has revealed that defects in alternative splicing contribute to a variety of features of cancer development, including the modulation of cancer heterogeneity, evasion of apoptosis of cancer ...
Yaxuan, Sun, Xiaohui, Hu
openaire   +2 more sources

Integrative oncology: Addressing the global challenges of cancer prevention and treatment

Ca-A Cancer Journal for Clinicians, 2022
Jun J Mao,, Msce, Lorenzo Cohen, Karen M Mustian   +2 more
exaly  

A novel NTRK1 aberrant splicing variant

a novel variant c.850+5G>A in NTRK1, which broadened the and enriched the NTRK1 mutation ...
openaire   +1 more source

Aberrant splicing of the RAS oncogenes

2019
Siden opdagelsen af RAS generne (HRAS, NRAS og KRAS) blev disse hurtigt anerkendt som lovende terapeutiske mål, og omfattende forskning har gennem de sidste tre årtier givet indsigt i grundlæggende egenskaber af RAS og deres essentielle rolle i tumorgenese samt adskillige udviklingsforstyrrelser.
openaire   +1 more source

Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention

Ca-A Cancer Journal for Clinicians, 2017
Cynthia Morata-Tarifa, Joyce M Slingerland   +1 more
exaly  

Multidisciplinary standards of care and recent progress in pancreatic ductal adenocarcinoma

Ca-A Cancer Journal for Clinicians, 2020
Aaron J Grossberg, William L Hwang, Anirban Maitra   +2 more
exaly