Results 151 to 160 of about 509,731 (381)

Aberrations in Incentive Learning and Responding to Heroin in Male Rats After Adolescent or Adult Chronic Binge‐Like Alcohol Exposure

, 2020
Ewa Galaj, Eddy D. Barrera, Debra Morris, Yao‐Ying Ma, Robert Ranaldi   +4 more
openalex   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Immunologic aberrations, HIV seropositivity and seroconversion rates in patients with hemophilia B [PDF]

, 1987
DB Brettler, F Brewster, Pascale Levine, A Forsberg, Sharon M. Baker, JL Sullivan   +5 more
openalex   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Genome-wide plasma DNA aberrations of systemic lupus erythematosus [PDF]

, 2016
Rossa W. K. Chiu
openalex   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

High speed multi focal plane optical system [PDF]

, 1983
An apparatus for eliminating beamsplitter generated optical aberrations in a pupil concentric optical system providing a plurality of spatially separated images on different focal planes or surfaces is presented.
Minott, P. O.
core   +1 more source

A comprehensive ocular profile using multimodal imaging systems and surgical outcome in a patient with Alport syndrome

Oman Journal of Ophthalmology, 2023
Soumen Sadhu, Janarthanam Jothi Balaji, Bhaskar Srinivasan   +2 more
doaj   +1 more source

Identifying and Engineering the Stacking Sequence in CVD Grown Few-layer MoS₂ via Aberration-corrected STEM [PDF]

, 2017
Aiming Yan, Wei Chen, Colin Ophus, Jim Ciston, Christian Merino, Alex Zettl   +5 more
openalex   +1 more source

Genomic aberrations and survival in chronic lymphocytic leukemia.

New England Journal of Medicine, 2000
H. Döhner, S. Stilgenbauer, A. Benner, E. Leupolt, A. Kröber, L. Bullinger, K. Döhner, Martin Bentz, P. Lichter   +8 more
semanticscholar   +1 more source