Results 251 to 260 of about 190,415 (313)

High resolution genome-wide SNP array analyses on matched colorectal-based lung and brain metastases. [PDF]

J Cancer Res Clin Oncol
Brandt VP, Sander C, Holland L, Koschny R, Müller WC, Bläker H, Nestler U, Güresir E, Holland H.   +8 more
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Within-cohort associations between corneal epithelial remodeling and anterior corneal higher-order aberrations after FS-LASIK and KLEx (SMILE): a two-cohort descriptive study. [PDF]

Sci Rep
Yang X, Niu J, Wu H, Song S, Zhou Y.
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

A decade of ibrutinib for CLL with and without TP53 aberration: final report on an investigator-sponsored phase 2 study.

Blood
Itsara A, Rogness VM, Samples L, Yuan CM, Wang HW, Ahn IE, Farooqui MZH, Tian X, Sun C, Tomasulo E, Soto S, Superata J, Bezkorovaynaya L, Hughes TE, Nierman P, Wiestner A.   +15 more
europepmc   +1 more source

Research progress on postoperative higher-order aberrations after ICL implantation: patterns of change, influencing factors, and associated visual disturbances. [PDF]

Front Med (Lausanne)
Hao Z, Zhao L, Pei Y, Nie L.
europepmc   +1 more source

Leveraging a spectrum of cytogenomics methods for profiling complex karyotypes in chronic lymphocytic leukemia. [PDF]

Hum Genomics
Cernovska K, Penazova S, Stranska K, Porc JP, Skalakova P, Ondrouskova E, Rausch T, Svaton J, Tausova K, Kazdova N, Pal K, Hynst J, Benes V, Jarosova M, Pospisilova S, Kotaskova J, Plevova K.   +16 more
europepmc   +1 more source

Preliminary diagnosis of eye health via wavefront parameters based on statistical frequency distributions. [PDF]

Eur J Med Res
Yang Y, Chen S, Yue X, Chen H, Yang F, Huang Q.   +5 more
europepmc   +1 more source

Interleukin-2 transcriptomic expression correlates with prolonged survival and with GNAS alterations in patients with advanced cancers. [PDF]

ESMO Open
Ahmed J, Nishizaki D, Fujiwara Y, DePietro P, Jensen TJ, McFall T, Kato S, Kurzrock R.   +7 more
europepmc   +1 more source