Results 101 to 110 of about 242,278 (345)

Evaluating the Potential for Resistance Development to Antimicrobial Blue Light (at 405 nm) in Gram-Negative Bacteria: In vitro and in vivo Studies

open access: yesFrontiers in Microbiology, 2018
Antimicrobial resistance is a threat to public health that requires our immediate attention. With increasing numbers of microbes that are becoming resistant to routinely used antimicrobials, it is vital that we look to other, non-traditional therapies ...
Leon G. Leanse   +5 more
doaj   +1 more source

Tumor angiogenic switch determines sustained proliferative malignant transformation in tumorigenesis and overlaps with para-inflammatory phenomena [PDF]

open access: yes, 2015
Contextual BCR-ABL tyrosine kinase over-activity determines in formulated fashion the emergence of proliferation and anti-apoptosis that arise largely as derived phenomena of otherwise homeostatic mechanisms of the c-ABL gene within hematopoietic ...
Agius, Lawrence M.
core  

Protein kinase Cδ and c-Abl kinase are required for transforming growth factor β induction of endothelial-mesenchymal transition in vitro. [PDF]

open access: yes, 2011
OBJECTIVE: The origin of the mesenchymal cells responsible for the intimal fibrosis in systemic sclerosis (SSc) has not been fully identified. The present study was undertaken to investigate whether subendothelial mesenchymal cells may emerge through ...
Jimenez, Sergio A., Li, zhaodong
core   +2 more sources

Uncovering the Drivers of the Equatorial Ocean Surface Winds

open access: yesQuarterly Journal of the Royal Meteorological Society, EarlyView.
Wind Patterns along the Equator. Shown are daily mean wind patterns along the equatorial basin indicated in Figure 1a as a meridional mean along −2∘$$ -{2}^{\circ } $$ to +2∘$$ +{2}^{\circ } $$ latitude, land cells included, from a 2‐year ICON simulation. Five ocean basins are shown in black. Yellow boxes outline the seasons and ocean basins, which are
Marius Winkler   +3 more
wiley   +1 more source

Mean and Flux Horizontal Variability of Virtual Potential Temperature, Moisture, and Carbon Dioxide: Aircraft Observations and LES Study [PDF]

open access: yes, 2008
The effects of the horizontal variability of surface properties on the turbulent fluxes of virtual potential temperature, moisture, and carbon dioxide are investigated by combining aircraft observations with large-eddy simulations (LESs).
Górska, M.   +3 more
core   +2 more sources

Total energy conservation for explaining discrepancies between field observations and the traditional thermal energy balance

open access: yesQuarterly Journal of the Royal Meteorological Society, EarlyView.
Motivated by discrepancies between field observations and the traditional thermal energy balance derived from the first law of thermodynamics, total energy conservation is applied to derive a generalized thermal energy balance for atmospheric applications. Total energy conservation accounts for all forms of energy variation, including kinetic, thermal,
Jielun Sun, Joseph Tribbia
wiley   +1 more source

Sensitivity of near‐surface marine winds and wind stress in coastal Antarctica to regional atmospheric model configuration

open access: yesQuarterly Journal of the Royal Meteorological Society, EarlyView.
Marine winds near coastal Antarctica are important for sea‐ice variability and ocean circulation. We test the sensitivity of simulated winds to varying uncertain aspects of the atmospheric model configuration. Winds (each configuration a coloured solid line in the figure) are sensitive to model physics, and notably we find that wind stress over a ...
Thomas Caton Harrison   +5 more
wiley   +1 more source

BCR-ABL1 tyrosine kinase sustained MECOM expression in chronic myeloid leukaemia [PDF]

open access: yes, 2012
MECOM oncogene expression correlates with chronic myeloid leukaemia (CML) progression. Here we show that the knockdown of MECOM (E) and MECOM (ME) isoforms reduces cell division at low cell density, inhibits colony-forming cells by 34% and moderately ...
Alzuherri   +53 more
core   +1 more source

Large‐eddy simulation with Lagrangian cloud modeling and large‐scale dynamics (L3$$ {\mathrm{L}}^3 $$) for studying the marine fog life cycle

open access: yesQuarterly Journal of the Royal Meteorological Society, EarlyView.
This study explores the life cycle of marine fog using a novel L3$$ {\mathrm{L}}^3 $$ coupling method, which integrates large‐eddy simulation (LES), Lagrangian cloud modeling (LCM), and large‐scale dynamics (LSD). Simulations of two fog episodes observed during the FATIMA campaign revealed key insights into the fog's microphysical and dynamic ...
Anup Barve   +4 more
wiley   +1 more source

Hyaluronic Acid‐Decorated Liposomes for the Intrapulmonary Delivery of Imatinib: A Targeted Treatment for Postinflammatory Pulmonary Fibrosis

open access: yesSmall Science, EarlyView.
Hyaluronic acid‐decorated imatinib‐loaded liposomes are developed to specific target CD44 receptor expressed by interstitial lung fibrosis cells, demonstrating higher uptake than empty liposomes. Based on promising in vitro data, they are administered intratracheally and intraperitoneally in a mouse bleomycin model, assessing their ability to decrease ...
Sara Bozzini   +13 more
wiley   +1 more source

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