Results 121 to 130 of about 217,258 (295)

Restoration of Mir-185 in Combination with BCR-ABL Downregulation By Therapeutic Delivery of siRNA with Lipid Nanoparticle Carriers Targets Drug Resistant Leukemic Stem/Progenitor Cells [PDF]

, 2023
Athena Phoa, Min Chen, Xiaoyan Jiang
openalex   +1 more source

Remnant Case Forms and Patterns of Syncretism in Early West Germanic

Transactions of the Philological Society, EarlyView.
Abstract Early stages of the Old West Germanic languages differ from the other two branches, Gothic and Norse, by showing remnants of a fifth case in a‐ and ō‐stem nouns. The forms in question, which have the ending ‐i or ‐u, are conventionally labelled ‘instrumental’ and cover a range of functions, such as instrument, means, comitative and locative ...
Will Thurlwell
wiley   +1 more source

Universal Cytomegalovirus Screening in the First Trimester of Pregnancy: The Multicentre Observational Cohort Study in the Area of Barcelona (CITEMB Study)

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To determine the CMV seroprevalence among pregnant women and assess the rate of primary CMV infections during the first trimester. Design Prospective multicentre observational cohort study. Setting Four primary care centres (ASSIRs) and two tertiary hospitals in Barcelona and its metropolitan area. Pupulation or Sample Pregnant women
María Ángeles Sánchez‐Durán, Juliana Esperalba, Elena Scazzocchio, Irene Fernández‐Torm, Eva Vázquez‐Segura, Olga Gracia‐Salazar, Marta Calveiro‐Hermo, Jordina Munrós‐Feliu, Astrid Francesch‐Campi, Laia Alcoverro‐Bedos, Aleida Ribas‐Tristany, Cristina del Viso‐Lajara, Julia Mitjans‐Carrasco, Mercedes Guerrero‐Martínez, Gema Fernández‐Rivas, Aneta Monika Zientalska, Liudmila Liutsko, Gemma Falguera‐Puig, Cristina Martínez‐Bueno, Nerea Maiz, Roser Gol, the CITEMB group   +21 more
wiley   +1 more source

Helicobacter pylori-controlled c-Abl localization promotes cell migration and limits apoptosis

Cell Communication and Signaling, 2019
Background Deregulated c-Abl activity has been intensively studied in a variety of solid tumors and leukemia. The class-I carcinogen Helicobacter pylori (Hp) activates the non-receptor tyrosine kinase c-Abl to phosphorylate the oncoprotein cytotoxin ...
Gernot Posselt, Maria Wiesauer, Bianca E. Chichirau, Daniela Engler, Linda M. Krisch, Gabriele Gadermaier, Peter Briza, Sabine Schneider, Francesco Boccellato, Thomas F. Meyer, Cornelia Hauser-Kronberger, Daniel Neureiter, Anne Müller, Silja Wessler   +13 more
doaj   +1 more source

Supplementary Figure 3 from Extracellular Visfatin-Promoted Malignant Behavior in Breast Cancer Is Mediated Through c-Abl and STAT3 Activation

, 2023
Amos C. Hung, Steven Lo, Ming‐Feng Hou, Yi‐Chen Lee, Chun‐Hao Tsai, Yuanyin Chen, Wangta Liu, Yu‐Han Su, Yi-Hsuan Lo, Chie‐Hong Wang, Shiou-Chen Wu, Ya‐Ching Hsieh, Stephen Chu‐Sung Hu, Ming‐Hong Tai, Yun‐Ming Wang, Shyng‐Shiou F. Yuan   +15 more
openalex   +1 more source

Calcitonin‐like diuretic hormone influences reproduction in adult female Rhodnius prolixus

Insect Science, EarlyView.
Highlights • CT/DH‐like immunoreactivity is present in female reproductive tissues • CT/DH receptor transcripts are expressed in the fat body and ovaries • RNAi knockdown of CT/DH receptors reduces egg number and hatching rate • Rhopr‐CT/DH increases RhoprVg1 and RhoprVgR expression in ovaries in vitro • Rhopr‐CT/DH stimulates oviduct contractions in a
Areej N. Al‐Dailami, Ian Orchard, Angela B. Lange   +2 more
wiley   +1 more source

Novel methotrexate long-acting system using ambroxol coating and hydroxypropyl methylcellulose encapsulation for preferential and enhanced lung cancer efficiency.

PLoS ONE
Methotrexate (MTX) is classified as an antimetabolite. It's commonly used to treat lung cancer. MTX is an immunosuppressant following the above-mentioned mechanism of action due to its poor selectivity.
Samaa Abdullah, Najla Altwaijry, Meaad Alnakhli, Ghezlan ALenezi, Alaa A Al-Masud, Hanan Henidi, Yahya F Jamous   +6 more
doaj   +1 more source

Dissection of the BCR-ABL signaling network using highly specific monobody inhibitors to the SHP2 SH2 domains [PDF]

, 2013
Fern Sha, Emel Başak Gençer, Sandrine Georgeon, Akiko Koide, N. Yasui, Shohei Koide, Oliver Hantschel   +6 more
openalex   +1 more source

Supplementary Figure 2 from <i>In vitro</i> Activity of Bcr-Abl Inhibitors AMN107 and BMS-354825 against Clinically Relevant Imatinib-Resistant Abl Kinase Domain Mutants

, 2023
Thomas O’Hare, Denise K. Walters, Eric P. Stoffregen, Taiping Jia, Paul W. Manley, Jürgen Mestan, Sandra W. Cowan‐Jacob, Francis Y. Lee, Michael C. Heinrich, Michael W. Deininger, Brian Druker   +10 more
openalex   +1 more source

Optimizing Donor Kidneys During Normothermic Machine Perfusion With Sevoflurane: Design of a Research Model

Artificial Organs, EarlyView.
A stable kidney normothermic machine perfusion model with sevoflurane delivery via a vaporizer was established, enabling mechanistic and therapeutic studies of ischemia–reperfusion injury. ABSTRACT Normothermic machine perfusion (NMP) of donor kidneys provides an opportunity not only for organ preservation but also for therapeutic intervention to ...
Philip N. Günkel, Shuqi Yang, Rozemarijn S. Tuinhout, Sebastiaan J. Luttik, Roland F. Hoffmann, Petra J. Ottens, Damien Richard, Matthieu Jabaudon, Michel M. R. F. Struys, Henri G. D. Leuvenink, Gertrude J. Nieuwenhuijs‐Moeke   +10 more
wiley   +1 more source