Results 121 to 130 of about 62,826 (275)

High‐throughput screening identifies bazedoxifene as a potential therapeutic for dysferlin‐deficient limb girdle muscular dystrophy

British Journal of Pharmacology, Volume 182, Issue 13, Page 2930-2949, July 2025.
Abstract Background and Purpose Limb‐girdle muscular dystrophy R2 (LGMD R2) is a rare genetic disorder characterised by progressive weakness and wasting of proximal muscles. LGMD R2 is caused by the loss of function of dysferlin, a transmembrane protein crucial for plasma membrane repair in skeletal muscles.
Celine Bruge, Nathalie Bourg, Emilie Pellier, Johana Tournois, Jerome Polentes, Manon Benabides, Noella Grossi, Anne Bigot, Anthony Brureau, Isabelle Richard, Xavier Nissan   +10 more
wiley   +1 more source

Labeling of v‐Src and BCR‐ABL tyrosine kinases with [¹⁴C]herbimycin A and its use in the elucidation of the kinase inactivation mechanism [PDF]

, 1994
Hidesuke Fukazawa, Yoshimasa Uehara, Yuko Murakami, Satoshi Mizuno, MASA HAMADA, TOMIO TAKEUCHI   +5 more
openalex   +1 more source

Diurnal Dependence of Boreal Winter Surface Air Temperature Responses to ENSO Across Global Land Areas

Geophysical Research Letters, Volume 52, Issue 11, 16 June 2025.
Abstract The El Niño‐Southern Oscillation (ENSO) significantly influences the seasonal‐to‐interannual variability of surface air temperature (SAT) over global land areas. Using the high temporal resolution ERA5 data set, we identify eight land regions where ENSO's impact on boreal winter SAT exhibits a pronounced diurnal dependence: southern North ...
Jing Xu, Xin Geng, Wenjun Zhang
wiley   +1 more source

Ready and Abl [PDF]

Nature Cell Biology, 2002
openaire   +3 more sources

T-cell immunity to the joining region of p210BCR-ABL protein. [PDF]

, 1992
W Chen, David Peace, Douglas Rovira, Shu-Han You, Martin A. Cheever   +4 more
openalex   +1 more source

Therapeutic Potential of Lipid Nanoparticle‐Encapsulated CD19‐Targeting mRNAs in Lupus and Rheumatoid Arthritis

Advanced Science, Volume 12, Issue 21, June 5, 2025.
This study develops lipid nanoparticle‐encapsulated mRNA‐encoding antibodies (mRNab‐LNPs) targeting CD19, demonstrating robust anti‐CD19 antibody production in vivo. Intramuscular injection of mRNab‐LNPs reduces CD19+ B and plasma cells in lupus and rheumatoid arthritis mice, significantly alleviating histopathological changes and tissue injuries of ...
Chipeng Guo, Yingsen Tang, Ling Zeng, Xiaomei You, Siweier Luo, Yufei Du, Le Wang, Liangchun Wang, Jianchuan Wang, Jinjin Chen, Yiming Zhou   +10 more
wiley   +1 more source

Expression of the 6C3 antigen on murine hematopoietic neoplasms. Association with expression of abl, ras, fes, src, erbB, and Cas NS-1 oncogenes but not with myc.

, 1987
Herbert C. Morse, George F. Tidmarsh, Kevin L. Holmes, Thomas Frederickson, Jacqueline Hartley, Jacalyn H. Pierce, Wallace Y. Langdon, Morris O. Dailey, I L Weissman   +8 more
openalex   +1 more source

Induction of BCR‐ABL Fusion Genes by in vitro X‐irradiation [PDF]

, 1993
Takashi Ito, Toshio Seyama, Terumi Mizuno, Tomonori Hayashi, Keisuke S. Iwamoto, Kiyohiko Dohi, Nori Nakamura, Mitoshi Akiyama   +7 more
openalex   +1 more source

Integration of Optical Genome Mapping in the Cytogenomic and Molecular Work‐Up of Hematological Malignancies: Expert Recommendations From the International Consortium for Optical Genome Mapping

American Journal of Hematology, Volume 100, Issue 6, Page 1029-1048, June 2025.
ABSTRACT The latest updates to the classification of hematolymphoid malignancies using the World Health Organization (WHO, 5th ed.) and ICC (International Consensus Classification) criteria highlight the critical need for comprehensive and precise cytogenomic data for diagnosis, prognostication, and treatment.
Rashmi Kanagal‐Shamanna, Anna Puiggros, Isabel Granada, Gordana Raca, Katrina Rack, Mar Mallo, Barbara Dewaele, Adam C. Smith, Yassmine Akkari, Brynn Levy, Robert P. Hasserjian, Adela Cisneros, Marta Salido, Guillermo Garcia‐Manero, Hui Yang, M. Anwar Iqbal, Ravindra Kolhe, Francesc Solé, Blanca Espinet   +18 more
wiley   +1 more source

Mutagenic analysis of the roles of SH2 and SH3 domains in regulation of the Abl tyrosine kinase.

, 1994
Bruce J. Mayer, David Baltimore
openalex   +1 more source