Results 121 to 130 of about 208,281 (313)

A Small Molecule Inhibitor, OGP46, Is Effective against Imatinib-Resistant BCR-ABL Mutations via the BCR-ABL/JAK-STAT Pathway

open access: yesMolecular Therapy: Oncolytics, 2020
Chronic myeloid leukemia (CML) is caused by the Philadelphia (Ph+) chromosome carrying the BCR-ABL oncogene, a constitutively active tyrosine kinase. The discovery of imatinib represents a major success story in the treatment against CML.
Liuya Wei   +13 more
doaj  

Persistence of chronic myelocytic leukemia despite deletion of rearranged bcr/c-abl sequences in blast crisis. [PDF]

open access: bronze, 1986
Claus R. Bartram   +4 more
openalex   +1 more source

The Development of Indo‐Iranian Voiced Fricatives

open access: yesTransactions of the Philological Society, Volume 123, Issue 1, Page 97-115, March 2025.
Abstract The development of voiced sibilants is a long‐standing puzzle in Indo‐Iranian historical phonology. In Vedic, all voiced sibilants are lost from the system, but the details of this loss are complex and subject to debate. The most intriguing development concerns the word‐final ‐aḥ to ‐o in sandhi.
Gašper Beguš
wiley   +1 more source

Health Equity Benefits All Communities (Including White Ones)

open access: yesThe Milbank Quarterly, EarlyView.
Policy Points Despite the goal of “all communities thriving,” health equity–focused scientists and advocates have inadvertently made it easier for those “opposed to equity” to falsely convince many White communities that health equity–promoting policies and programs do not benefit them or their health.
PHILIP M. ALBERTI
wiley   +1 more source

Minority Farmer and Rancher Delinquency and Local Cultural Climate: Evidence from Farm Service Agency's County Office Committees

open access: yesAmerican Journal of Agricultural Economics, EarlyView.
Abstract Farm delinquency is linked to many negative indicators of farm survival, including increased risk of bankruptcy and farm failure. Minority farmers and ranchers (MFR) have been found to exhibit higher rates of delinquency on U.S. Department of Agriculture (USDA) Farm Service Agency (FSA) loans compared to their non‐Hispanic White male ...
Lawson Connor   +3 more
wiley   +1 more source

Modeling of an Atmospheric-Boundary-Layer Profile in Support of Experiments in the NASA Langley Transonic Dynamics Tunnel [PDF]

open access: yes
This paper presents the results of the Computational Fluid Dynamics (CFD) analyses to model two atmospheric-boundary-layer (ABL) profiles inside the NASA Langley Research Center Transonic Dynamics Tunnel (TDT). The CFD models include tunnel walls and all
Chwalowski, Pawel, Ivanco, Thomas G.
core   +1 more source

892 ABL503 (TJ-L14B), PD-L1x4–1BB bispecific antibody induces superior anti-tumor activity by PD-L1-dependent 4–1BB activation with the increase of 4–1BB+CD8+ T cells in tumor microenvironment

open access: yesJournal for ImmunoTherapy of Cancer, 2021
Wenqing Jiang   +12 more
doaj   +1 more source

Imatinib decreases germ cell survival and germline stem cell proliferation in rodent testis ex vivo and in vitro

open access: yesAndrology, EarlyView.
Abstract Background Imatinib and dasatinib are tyrosine kinase inhibitors (TKIs) increasingly used to treat several diseases in both children and adults at fertile age. We have previously shown that imatinib has adverse effects on developing testis, and imatinib‐treated male patients have been reported to have reduced sperm counts.
Anna Eggert   +10 more
wiley   +1 more source

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