Results 201 to 210 of about 208,281 (313)

Computational Insights into the Polypharmacological Landscape of BCR-ABL Inhibitors: Emphasis on Imatinib and Nilotinib. [PDF]

Pharmaceuticals (Basel)
Hajjo R, Sabbah DA, Alhaded R, Alquabe'h A, Bardaweel SK.   +4 more
europepmc   +1 more source

The Dimerization Property of Glutathione -Transferase Partially Reactivates Bcr-Abl Lacking the Oligomerization Domain [PDF]

, 1996
Yoshiro Maru, Daniel Afar, Owen N. Witte, Masabumi Shibuya   +3 more
openalex   +1 more source

Multi‐Target Drug Design in Alzheimer's Disease Treatment: Emerging Technologies, Advantages, Challenges, and Limitations

Pharmacology Research &Perspectives, Volume 13, Issue 4, August 2025.
ABSTRACT Alzheimer's disease (AD) is a complex and multifactorial neurodegenerative disorder, recognized as the most prevalent form of dementia. It is characterized by multiple pathological processes, including amyloid‐beta accumulation, neurofibrillary tangles, and neuroinflammation. The therapeutic efficacy of traditional single‐target drugs has been
Md Saad Hossain, Md Hamed Hussain
wiley   +1 more source

BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias.

, 1991
Alexander J. Muller, Judy Young, Ann Marie Pendergast, Mark Pondel, NR Landau, Dan R. Littman, Owen N. Witte   +6 more
openalex   +1 more source

Peptides derived from the whole sequence of BCR‐ABL bind to several class I molecules allowing specific induction of human cytotoxic T lymphocytes [PDF]

, 1997
Agnès Buzyn, Marina Ostankovitch, A. Zerbib, M. Kemula, Francine Connan, Bruno Varet, Jean‐Gérard Guillet, Jeannine Choppin   +7 more
openalex   +1 more source

Quality of life for braille users: A scoping review

Review of Education, Volume 13, Issue 2, August 2025.
Abstract Quality of life (QoL) encompasses well‐being, life satisfaction and happiness, enabling individuals to lead meaningful lives. Literacy, the ability to read and write, is essential for inclusion in education, employment and society. For people with blindness or low vision (BLV), braille is a critical tool for accessing literacy.
Aasha Rose, Melissa Fanshawe, Georgina Barton, Melissa Cain   +3 more
wiley   +1 more source

c-Abl/TFEB Pathway Activation as a Common Pathogenic Mechanism in Lysosomal Storage Diseases: Therapeutic Potential of c-Abl Inhibitors. [PDF]

Antioxidants (Basel)
Guerra MV, Castro J, Moreno A, Balboa E, Marugan JJ, Alvarez AR, Zanlungo S.   +6 more
europepmc   +1 more source

Can Active Blended Learning Instruction Enhance Reading Comprehension?

Journal of Computer Assisted Learning, Volume 41, Issue 4, August 2025.
ABSTRACT Background Reading is a multifaceted skill that plays a crucial role in language acquisition. The acquisition of this skill can be influenced by various instructional strategies and methods. There are studies in literature that show the effect of blended or collaborative teaching methods on reading skills; however, there is a lack of studies ...
Berrin Köseoğlu, Alev Ateş Çobanoğlu   +1 more
wiley   +1 more source

A dedicated skin-to-brain circuit for cool sensation in mice. [PDF]

Nat Commun
Lee H, Hor CC, Horwitz LR, Xiong A, Su XY, Soden DR, Yang S, Cai W, Zhang W, Li C, Radcliff C, Dinh A, Fung TLR, Rovcanin I, Pipe KP, Xu XZS, Duan B.   +16 more
europepmc   +1 more source

Inhibition of BCR-ABL Expression With Antisense Oligodeoxynucleotides Restores β1 Integrin-Mediated Adhesion and Proliferation Inhibition in Chronic Myelogenous Leukemia Hematopoietic Progenitors [PDF]

, 1998
Ravi Bhatia, Catherine M. Verfaillie
openalex   +1 more source