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Classroom provision for the able and the exceptionally able [PDF]
Support for Learning, 1994 Ralph Callow has worked for many years with exceptionally able pupils. He describes the two recommended approaches for dealing with the challenges posed by such pupils: enrichment and acceleration. He also gives us a fascinating insight into the progress of ‘Simon’, a child of outstanding ability. It is a compliment to the profession that Simon's needs
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Blood, 2001
Chronic myelogenous leukemia (CML) has long been a hunting ground for specific therapies of cancer because the disease is initiated by a single, unique chromosomal translocation. The translocation fusion gene product is the target of the first rationally designed tumor inhibitor STI571 ...
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Chronic myelogenous leukemia (CML) has long been a hunting ground for specific therapies of cancer because the disease is initiated by a single, unique chromosomal translocation. The translocation fusion gene product is the target of the first rationally designed tumor inhibitor STI571 ...
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CRKL Binding to BCR-ABL and BCR-ABL Transformation
Leukemia & Lymphoma, 1999The SH2-SH3 domain-containing adaptor protein CRKL is the predominant tyrosine phosphorylated protein in chronic myelogenous leukemia (CML) neutrophils and BCR-ABL-expressing cell lines. The amino terminal CRKL SH3 domain binds directly to a proline-rich region in the C-terminus of BCR-ABL. BCR-ABL mutants with deletions of this region were constructed
Brian J. Druker +4 more
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Regulation of the c-Abl and Bcr–Abl tyrosine kinases
Nature Reviews Molecular Cell Biology, 2004The prototypic non-receptor tyrosine kinase c-Abl is implicated in various cellular processes. Its oncogenic counterpart, the Bcr-Abl fusion protein, causes certain human leukaemias. Recent insights into the structure and regulation of the c-Abl and Bcr-Abl tyrosine kinases have changed the way we look at these enzymes.
Oliver Hantschel, Giulio Superti-Furga
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Malignant transformation by abl and BCR/ABL
1993Activated abl oncogenes have been implicated in causing pre-B lymphoma in mice via Abelson murine leukemia virus, fibrosarcoma in cats via Hardy-Zuckerman feline sarcoma virus II, and, through the Philadelphia chromosome, are linked with the myeloproliferative syndrome chronic myelogenous leukemia and with acute lymphoid and myeloid leukemia in humans.
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Ablative and Non-ablative Fractional Resurfacing
2012Fractionated laser resurfacing leads to improvement of photodamaged skin, rhytides and acne scars. In contrast to non-fractionated ablative laser resurfacing, fractionated ablative laser resurfacing is associated with lower risk of complications and less downtime.
David H. Ciocon +3 more
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Blood Reviews, 1999
gene on chromosome 9 is the humanhomologue of a gene originally identified in a murineoncogenic virus, the Abelson murine leukaemia virus(A-MuLV). This retrovirus was isolated from a pred-nisolone treated mouse which developed lymphomafollowing innoculation with Moloney murineleukaemia virus (M-MuLV).
Qingqiu Pu +2 more
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gene on chromosome 9 is the humanhomologue of a gene originally identified in a murineoncogenic virus, the Abelson murine leukaemia virus(A-MuLV). This retrovirus was isolated from a pred-nisolone treated mouse which developed lymphomafollowing innoculation with Moloney murineleukaemia virus (M-MuLV).
Qingqiu Pu +2 more
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The International Journal of Psychoanalysis, 2003
In this paper, the author explores the phenomenon of not being able to dream (as opposed to not being able to remember one's dreams) from three different vantage points. First, from the point of view of psychoanalytic theory, he discusses Bion's idea that the work of dreaming creates the conscious and unconscious mind (and not the other way around).
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In this paper, the author explores the phenomenon of not being able to dream (as opposed to not being able to remember one's dreams) from three different vantage points. First, from the point of view of psychoanalytic theory, he discusses Bion's idea that the work of dreaming creates the conscious and unconscious mind (and not the other way around).
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Leukemia Research, 1996
This review focuses on the role of the chimeric BCR/ABL gene in leukemia development. First, we discuss and update knowledge regarding the molecular biology of BCR/ABL. We then review data regarding transforming activity of BCR/ABL. Third, we discuss the complex interactions between BCR/ABL and leukemia phenotype. We conclude with a brief discussion of
Anna Butturini +2 more
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This review focuses on the role of the chimeric BCR/ABL gene in leukemia development. First, we discuss and update knowledge regarding the molecular biology of BCR/ABL. We then review data regarding transforming activity of BCR/ABL. Third, we discuss the complex interactions between BCR/ABL and leukemia phenotype. We conclude with a brief discussion of
Anna Butturini +2 more
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Complications of Fractional Lasers (Ablative and Non-ablative)
2016Fractionated laser technology has allowed physicians to minimize downtime and complications increasing the number of treatments with lower rate of complications than non-fractionated laser treatment, especially for eyelid and perioral region treatments.
Norma Cameli, Maria Mariano
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