Results 81 to 90 of about 217,258 (295)
Genetic requirement for Ras in the transformation of fibroblasts and hematopoietic cells by the Bcr-Abl oncogene. [PDF]
, 1995 To determine the functional importance of Ras in transformation by Abl oncogenes, we used a genetic approach to measure the effect of impaired Ras activity on the ability of Bcr-Abl or v-Abl to transform cells.
McLaughlin, J, Sawyers, CL, Witte, ON
core
Two-scale momentum theory for very large wind farms [PDF]
, 2016 A new theoretical approach is proposed to predict a practical upper limit to the efficiency of a very large wind farm. The new theory suggests that the efficiency of ideal turbines in an ideal very large wind farm depends primarily on a non-dimensional ...
Nishino, Takafumi
core +2 more sources
Investor Perception of ESG in Earnings Calls
Business Strategy and the Environment, EarlyView.ABSTRACT This study examines how the communicator's role and the framing of ESG statements affect investor capital allocation in the context of earnings calls. Based on a virtual asset market experiment, the analysis identifies that the assurance and reinforcement of ESG messages have a positive effect of up to 8% on capital allocation, with especially
Felix Bachner
wiley +1 more source
PLoS ONE, 2014 ABL tyrosine kinase inhibitors (TKI) like Imatinib, Dasatinib and Nilotinib are the gold standard in conventional treatment of CML. However, the emergence of resistance remains a major problem.
Anna L Illert +8 more
doaj +1 more source
Tumor angiogenic switch determines sustained proliferative malignant transformation in tumorigenesis and overlaps with para-inflammatory phenomena [PDF]
, 2015 Contextual BCR-ABL tyrosine kinase over-activity determines in formulated fashion the emergence of proliferation and anti-apoptosis that arise largely as derived phenomena of otherwise homeostatic mechanisms of the c-ABL gene within hematopoietic ...
Agius, Lawrence M.
core
Chemistry – A European Journal, EarlyView.Conformational restriction strategies to increase the activity and selectivity of the STAT5b inhibitor Stafib‐2 are presented. The best conformationally restricted inhibitor Stafib‐2‐CR has threefold higher activity against STAT5b than Stafib‐2. A cell‐permeable prodrug of Stafib‐2‐CR inhibits phosphorylation of STAT5b in cultured human leukemia cells ...
Theresa Münzel +5 more
wiley +1 more source
Mofina Mendes e o pote de azeite, antes e depois
Convergência Lusíada, 2017 O Auto dos mistérios da Virgem, representado nas matinas do Natal de 1534, é uma reorganização de um ludus prophetarum medieval. Não passaria de mais um edificante auto sacro, não fosse a presença de forte figura alegórica, Mofina Mendes, ou seja a ...
Ronaldo Menegaz
doaj
A Subvoxel Correction of Boiling-Induced Susceptibility Artifacts in Magnetic Resonance Thermometry and Dosimetry for Monitoring Microwave Thermoablation: A Feasibility Study in a Swine Model. [PDF]
Magn Reson MedABSTRACT Purpose Real‐time monitoring of microwave liver ablation (MWA) using MRI thermometry can be hindered by boiling‐induced susceptibility artifacts. These artifacts cause large temperature measurement errors that prevent accurate lesion size prediction.
Dantas E +6 more
europepmc +2 more sources
Clinical Pharmacology &Therapeutics, EarlyView.Vascular leakage and its associated phenomena vasodilation and endothelial activation are pathophysiological features of various diseases. Multiple drug candidates targeting these phenomena are in development, necessitating translational models to demonstrate proof‐of‐pharmacology and proof‐of‐mechanism in early‐phase clinical trials.
Marella Cornelia Elizabeth van Ruissen +10 more
wiley +1 more source
Diagnosis of Local Land-Atmosphere Feedbacks in India [PDF]
, 2011 Following the convective triggering potential (CTP)–humidity index (HIlow) framework by Findell and Eltahir, the sensitivity of atmospheric convection to soil moisture conditions is studied for India.
Hutjes, R.W.A. +3 more
core +2 more sources