Results 91 to 100 of about 793,672 (364)

The [2Fe‐2S] cluster of mitochondrial outer membrane protein mitoNEET has an O2‐regulated nitric oxide access tunnel

open access: yesFEBS Letters, EarlyView.
The mitochondrial outer membrane iron–sulphur ([Fe‐S]) protein mitoNEET is a target of the type‐2 diabetes drug pioglitazone. Its unknown molecular function is linked to respiratory complex activity and mitochondrial function. We discovered that O2 protects the mitoNEET [2Fe‐2S] cluster against NO oxidation and desensitization towards reduction by H2S.
Thao Nghi Hoang   +9 more
wiley   +1 more source

The use of laser interstitial thermal therapy in the treatment of brain metastases: a literature review

open access: yesInternational Journal of Hyperthermia, 2020
Purpose The aim of this paper is to discuss the current evidence for Laser Interstitial Thermal Therapy (LITT) in the treatment of brain metastases, our current recommendations for patient selection and the future perspectives for this therapy.
Dhiego Chaves de Almeida Bastos   +8 more
doaj   +1 more source

Cryothermal Energy Ablation Of Cardiac Arrhythmias 2005: State Of The Art [PDF]

open access: yes, 2005
At the time of antiarrhythmic surgery, cryothermal energy application by a hand-held probe was used to complement dissections and resections and permanently abolish the arrhythmogenic substrate.
De Ponti, Roberto
core   +2 more sources

A histidine‐rich extension of the mitochondrial F0 subunit ATP6 from the ice worm Mesenchytraeus solifugus increases ATP synthase activity in bacteria

open access: yesFEBS Letters, EarlyView.
The glacier ice worm Mesenchytraeus solifugus survives year‐round at 0 °C. Its ATP6 subunit, which forms a regulatory component of the proton pore in mitochondrial ATP synthase, has a carboxy‐terminal extension not found in any other organism examined to date. Here, we show that fusion of this extension to the homologous AtpB protein in E. coli results
Truman Dunkley   +2 more
wiley   +1 more source

Radiofrequency ablation devices [PDF]

open access: yesVideoGIE, 2017
The use of RFA as a treatment modality in gastrointestinal endoscopy is expanding. RFA is frequently used in combination with focal EMR for the treatment of dysplastic BE and as standalone therapy for flat BE. Its efficacy in the treatment of esophageal squamous dysplasia appears promising.
Rahul Pannala   +9 more
openaire   +4 more sources

Ablation of LRP6 in alpha‐smooth muscle actin‐expressing cells abrogates lung inflammation and fibrosis upon bleomycin‐induced lung injury

open access: yesFEBS Letters, EarlyView.
Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung   +6 more
wiley   +1 more source

Mass diffusion and liner material effect in a MagLIF fusion-like plasma [PDF]

open access: yes, 2018
In this paper, liner - fuel mass diffusion and the effect of the liner material on mass ablation, energy and magnetic flux losses are studied in a MagLIF fusion-like plasma. The analysis performed in [Garc\'ia-Rubio and Sanz, Phys. Plasmas 24, 072710 (2017)] is extended to liner materials of an arbitrary atomic number.
arxiv   +1 more source

Laser ablation loading of a surface-electrode ion trap

open access: yes, 2007
We demonstrate loading by laser ablation of $^{88}$Sr$^+$ ions into a mm-scale surface-electrode ion trap. The laser used for ablation is a pulsed, frequency-tripled Nd:YAG with pulse energies of 1-10 mJ and durations of 3-5 ns.
C. R. Phipps   +14 more
core   +1 more source

Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases

open access: yesFEBS Letters, EarlyView.
The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher   +6 more
wiley   +1 more source

Nanosecond laser ablation of Si(111) under an aqueous medium [PDF]

open access: yes, 2018
Nanosecond laser ablation of p-type Si(111) wafer is presented under an ambient, a water and a glycerin conditions. Effects of pulse energy, number of pulses and type of environment are systematically analyzed with an Optical Profilometer, a Scanning Electron Microscope and an Atomic Force Microscope.
arxiv   +1 more source

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