Results 101 to 110 of about 377,806 (268)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Obese patients exhibit a greater enhancement in mental health-related quality of life compared to non-obese patients following thoracoscopic ablation of atrial fibrillation

Frontiers in Cardiovascular Medicine
BackgroundObesity is an important risk factor for atrial fibrillation (AF) development and progression. Furthermore, obesity reduces health-related quality of life (HRQoL), an essential indicator for treatment efficacy of AF ablation.
Eva R. Meulendijks, Eva R. Meulendijks, Manouck J. M. Roelofs, Manouck J. M. Roelofs, Tim A. C. de Vries, Tim A. C. de Vries, Robin Wesselink, Robin Wesselink, Rushd F. M. Al-Shama, Rushd F. M. Al-Shama, Wim-Jan P. van Boven, Wim-Jan P. van Boven, Antoine H. G. Driessen, Antoine H. G. Driessen, Wouter R. Berger, Jonas S. S. G. de Jong, Joris R. de Groot, Joris R. de Groot   +17 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Percutaneous ablation for adrenal metastases: a systematic review and meta-analysis

Videosurgery and Other Miniinvasive Techniques, 2022
Jian-Hua Zhang, Yu-Fei Fu, Jing-Ya Wang
doaj   +1 more source

Clinical characteristics and treatment for laryngeal cyst in children: a case series study

Frontiers in Surgery
PurposeThis study aims to present a case series of pediatric laryngeal cysts and summarize their clinical characteristics and treatment outcomes.MethodsThis retrospective case series study included pediatric patients with laryngeal cysts at the author's ...
Pei Zhou, Lili Zhong, Xiaofang Ding, Mohammd Ashkan Moslehi, Silan Liu, Li Peng, Han Huang   +6 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Predictors of long‐term success after high‐density mapping‐guided substrate ablation procedures for ventricular tachycardia in patients with ischemic cardiomyopathy

Journal of Arrhythmia
Introduction High‐density (HD) substrate mapping may increase success of catheter ablation targeting ventricular tachycardia (VT). However, despite its use, recurrent VT is not uncommon.
J. C. Balt, B. G. S. Abeln, V. F. vanDijk, M. C. E. F. Wijffels, M. Liebregts, L. V. A. Boersma   +5 more
doaj   +1 more source