Results 91 to 100 of about 361,060 (267)

Obese patients exhibit a greater enhancement in mental health-related quality of life compared to non-obese patients following thoracoscopic ablation of atrial fibrillation

Frontiers in Cardiovascular Medicine
BackgroundObesity is an important risk factor for atrial fibrillation (AF) development and progression. Furthermore, obesity reduces health-related quality of life (HRQoL), an essential indicator for treatment efficacy of AF ablation.
Eva R. Meulendijks, Eva R. Meulendijks, Manouck J. M. Roelofs, Manouck J. M. Roelofs, Tim A. C. de Vries, Tim A. C. de Vries, Robin Wesselink, Robin Wesselink, Rushd F. M. Al-Shama, Rushd F. M. Al-Shama, Wim-Jan P. van Boven, Wim-Jan P. van Boven, Antoine H. G. Driessen, Antoine H. G. Driessen, Wouter R. Berger, Jonas S. S. G. de Jong, Joris R. de Groot, Joris R. de Groot   +17 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Percutaneous ablation for adrenal metastases: a systematic review and meta-analysis

Videosurgery and Other Miniinvasive Techniques, 2022
Jian-Hua Zhang, Yu-Fei Fu, Jing-Ya Wang
doaj   +1 more source

Clinical characteristics and treatment for laryngeal cyst in children: a case series study

Frontiers in Surgery
PurposeThis study aims to present a case series of pediatric laryngeal cysts and summarize their clinical characteristics and treatment outcomes.MethodsThis retrospective case series study included pediatric patients with laryngeal cysts at the author's ...
Pei Zhou, Lili Zhong, Xiaofang Ding, Mohammd Ashkan Moslehi, Silan Liu, Li Peng, Han Huang   +6 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Predictors of long‐term success after high‐density mapping‐guided substrate ablation procedures for ventricular tachycardia in patients with ischemic cardiomyopathy

Journal of Arrhythmia
Introduction High‐density (HD) substrate mapping may increase success of catheter ablation targeting ventricular tachycardia (VT). However, despite its use, recurrent VT is not uncommon.
J. C. Balt, B. G. S. Abeln, V. F. vanDijk, M. C. E. F. Wijffels, M. Liebregts, L. V. A. Boersma   +5 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source