Results 121 to 130 of about 493,058 (315)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Radiofrequency Ablation for Post Infarction Ventricular Tachycardia

, 2004
Radiofrequency ablation has an important role in the management of post infarction ventricular tachycardia. The mapping and ablation of ventricular tachycardia (VT) is complex and technically challenging.
Voltaire Nadurata, Nadurata, Voltaire, David ODonnell, O’Donnell, David   +3 more
core  

Micro-machining Techniques for the Fabrication of Fibre Fabry-Perot Sensors [PDF]

, 2006
Fabry-Perot optical fibre sensors have been used extensively for measuring a variety of parameters such as strain, temperature, pressure and vibration. Conventional extrinsic fibre Fabry-Perot sensors are associated with problems such as calibration of ...
Machavaram, V. R.
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Obese patients exhibit a greater enhancement in mental health-related quality of life compared to non-obese patients following thoracoscopic ablation of atrial fibrillation

Frontiers in Cardiovascular Medicine
BackgroundObesity is an important risk factor for atrial fibrillation (AF) development and progression. Furthermore, obesity reduces health-related quality of life (HRQoL), an essential indicator for treatment efficacy of AF ablation.
Eva R. Meulendijks, Eva R. Meulendijks, Manouck J. M. Roelofs, Manouck J. M. Roelofs, Tim A. C. de Vries, Tim A. C. de Vries, Robin Wesselink, Robin Wesselink, Rushd F. M. Al-Shama, Rushd F. M. Al-Shama, Wim-Jan P. van Boven, Wim-Jan P. van Boven, Antoine H. G. Driessen, Antoine H. G. Driessen, Wouter R. Berger, Jonas S. S. G. de Jong, Joris R. de Groot, Joris R. de Groot   +17 more
doaj   +1 more source

Laser Propulsion Standardization Issues

, 2010
It is a relevant issue in the research on laser propulsion that experimental results are treated seriously and that meaningful scientific comparison is possible between groups using different equipment and measurement techniques.
Sinko, John Elihu, Hans-Peter Röser, John E. Sinko, Stefan Scharring, Akihiro Sasoh, Eckel, Hans-Albert, Claude Phipps, Scharring, Stefan, Sasoh, Akihiro, Hans-Albert Eckel, Röser, Hans-Peter   +10 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Percutaneous ablation for adrenal metastases: a systematic review and meta-analysis

Videosurgery and Other Miniinvasive Techniques, 2022
Jian-Hua Zhang, Yu-Fei Fu, Jing-Ya Wang
doaj   +1 more source