Results 51 to 60 of about 187,327 (298)

Ablation behavior of C/C–Zr1-xHfxC-SiC composites under an oxyacetylene flame at above 2500 °C

Journal of Materials Research and Technology, 2023
In order to enhance ablation resistance of C/C composites, Zr1-xHfxC and SiC were introduced into C/C composites, and ablation behavior of the composites was studied.
Xiaoyang Jiao, Qinchuan He, Mingcong Qing, Yiqun Wang, Xuemin Yin   +4 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Nature-inspired (Ti,Zr,Hf)C/SiC micro-nano composites with enhanced ablation resistance through a Gobi Desert-like protective oxide layer

Journal of Advanced Ceramics
(Ti,Zr,Hf)C/SiC composites with micro-nano structure were designed inspired by the gravel–sand structure of the wind-resistant Gobi Desert to prevent air-plasma flame scouring and obtain excellent ablation resistance.
Li Lu, Shuibin Wang, Tianxing Jiang, Pengcheng Du, Jinrun Hu, Tianci Zhou, Yichen Wang, Yi Zeng, Yalei Wang, Xiang Xiong, Qingbo Wen   +10 more
doaj   +1 more source

The carotid body as a therapeutic target for the treatment of sympathetically mediated diseases [PDF]

, 2013
[no ...
Abdala, Ana P, Burchell, Amy, Engleman, Zoar J, Fudim, Marat, Gourine, Alexander V, Hart, Emma C J, Lobo, Mel, Marina, Nepthali, McBryde, Fiona D, Nightingale, Angus, Patel, Nik, Paton, Julian F R, Ratcliffe, Laura E K, Sobotka, Paul A   +13 more
core   +2 more sources

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function [PDF]

Nature, 2014
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers in western countries, with a median survival of 6 months and an extremely low percentage of long-term surviving patients. KRAS mutations are known to be a driver event of PDAC, but targeting mutant KRAS has proved challenging.
Viale A., Pettazzoni P., Lyssiotis C. A., Ying H., Sanchez N., Marchesini M., Carugo A., Green T., Seth S., Giuliani V., Kost-Alimova M., Muller F., Colla S., Nezi L., Genovese G., Deem A. K., Kapoor A., Yao W., Brunetto E., Kang Y., Yuan M., Asara J. M., Wang Y. A., Heffernan T. P., Kimmelman A. C., Wang H., Fleming J. B., Cantley L. C., DePinho R. A., Draetta G. F.   +29 more
openaire   +3 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Expanding the members of ultra-high temperature ceramics and their maximum service temperature exceeding 3000 °C

Journal of Advanced Ceramics
Aerodynamic heating, oxidation, ablation, and high dynamic pressure represent the extreme environments that aerospace vehicles must withstand during high-Mach atmospheric or trans-atmospheric flight. The temperature of critical components on the vehicles
Fei Li, Guo-Jun Zhang, Yanchun Zhou, Xinghong Zhang   +3 more
doaj   +1 more source

Distinct immune signatures in directly treated and distant tumors result from TLR adjuvants and focal ablation. [PDF]

, 2018
Both adjuvants and focal ablation can alter the local innate immune system and trigger a highly effective systemic response. Our goal is to determine the impact of these treatments on directly treated and distant disease and the mechanisms for the ...
Borowsky, Alexander D, Chavez, Michael, Davis, Ryan R, Ferrara, Katherine W, Fite, Brett Z, Hubbard, Neil E, Ilovitsh, Asaf, Ingham, Elizabeth S, Mahakian, Lisa M, Monjazeb, Arta M, Murphy, William J, Silvestrini, Matthew T, Tam, Sarah M, Tepper, Clifford G   +13 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Research on Electrical Contact Characteristics of Brush-Rail Device With Transient Large Current

IEEE Access, 2023
An excellent electrical contact state is necessary to ensure safe and stable operation of the system. Therein, contact resistance and arc ablation are essential indexes for estimating the contact state. In view of the characteristics of brush-rail device
Yanhao Wu, Jin Xu, Junjie Zhu, Wei Xu
doaj   +1 more source