Results 51 to 60 of about 9,574,494 (334)

Kras oncogene ablation prevents resistance in advanced lung adenocarcinomas

Journal of Clinical Investigation, 2023
KRASG12C inhibitors have revolutionized the clinical management of patients with KRASG12C-mutant lung adenocarcinoma. However, patient exposure to these inhibitors leads to the rapid onset of resistance. In this study, we have used genetically engineered mice to compare the therapeutic efficacy and the emergence of tumor resistance between genetic ...
Marina Salmón, Ruth Álvarez-Díaz, Coral Fustero-Torre, Oksana Brehey, Carmen G. Lechuga, Manuel Sanclemente, Fernando Fernández-García, Alejandra López-García, María Carmen Martín-Guijarro, Sandra Rodríguez-Perales, Emily Bousquet-Mur, Lucía Morales-Cacho, Francisca Mulero, Fátima Al-Shahrour, Lola Martínez, Orlando Domínguez, Eduardo Caleiras, Sagrario Ortega, Carmen Guerra, Monica Musteanu, Matthias Drosten, Mariano Barbacid   +21 more
openaire   +5 more sources

Update on CO2 Laser Ablation of Polyoxymethylene [PDF]

, 2010
Polyoxymethylene (POM) propellants have been studied since the 1970's, and perhaps represent the most promising match of a propellant to the CO2 laser for laser propulsion studies.
Sinko, John Elihu, Eckel, Hans-Albert, Sasoh, Akihiro, Scharring, Stefan, Ogita, Naoya, Röser, Hans-Peter   +5 more
core  

Lorlatinib‐Containing Therapy for MYCN‐Amplified, ALK‐Mutated Neuroblastoma With Bulky Leptomeningeal Relapse: A Case Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Central nervous system (CNS) relapse of neuroblastoma carries a poor prognosis, and craniospinal irradiation (CSI) poses substantial long‐term toxicity in young children. We report a toddler with MYCN‐amplified neuroblastoma harboring somatic ALK R1275Q who developed extensive leptomeningeal relapse with paraplegia.
Jinwoo Kim, Minji Kim, Nani Jung, Sung Eun Kim, Ji Yoon Kim, Mi Ae Chu, Jung Eun Kwon, Yeo Hyang Kim, So Mi Lee, Ki‐Su Park, Jeong Eun Lee, Ye Jee Shim   +11 more
wiley   +1 more source

Multi-anion sublattice engineering enables exceptional ablation-resistant performance in Hf0.8Zr0.2B0.1C0.5N0.4–SiC ultra-high temperature ceramics

Journal of Advanced Ceramics
High-entropy ultrahigh temperature ceramics (UHTCs) have garnered significant attention for their outstanding designability and performance, yet existing strategies remain largely confined to cationic sublattice engineering, leaving the potential of ...
Xiaoyu Wang, Dewei Ni, Bowen Chen, Feiyan Cai, Yang Hu, Yanmei Kan, Yusheng Ding, Shaoming Dong   +7 more
doaj   +1 more source

Laser ablation resistance and mechanism of Si-Zr alloyed melt infiltrated C/C-SiC composite [PDF]

, 2017
Ablation resistance of C/C-SiC composite prepared via Si-Zr alloyed reactive melt infiltration was evaluated using a facile and economical laser ablation method.
Hu, Yongle, Yicong Ye, Bai, Shuxin, Qing H. Qin, Tong, Yonggang, Qin, Qing H., Yongle Hu, Xiubing Liang, Yonggang Tong, Shuxin Bai, Liang, Xiubing, Ye, Yicong   +11 more
core   +1 more source

Effectiveness of Resistance Intradialytic Exercise Compared to Aerobic Intradialytic Exercise for Patients With Chronic Kidney Disease: A Randomized Controlled Clinical Trial

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Patients with chronic kidney disease undergoing hemodialysis commonly experience reduced physical function, fatigue, poor sleep quality, and impaired health‐related quality of life. Intradialytic exercise has been proposed as a non‐pharmacological strategy to improve these outcomes.
Klebson da Silva Almeida, Gisela Cristiane Miyamoto, Daniel da Costa Torres, Ian Setubal Reis Chaves, Jonas do Carmo Paschoalin, Braúlio Lima Nascimento, Luciana Dias Chiavegato   +6 more
wiley   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Heat dissipation of carbon shell in ZrC–SiC/TaC coating to improve protective ability against ultrahigh temperature ablation

Journal of Advanced Ceramics
To efficiently decrease ablation heat accumulation and improve the ability of ZrC–SiC/TaC coatings to protect carbon/carbon (C/C) composites, a thermally conductive nanonetwork with a ceramic@carbon core–shell structure was designed and constructed ...
Yuyu Zhang, Xuemeng Zhang, Hongkang Ou, Bozhe Wang, Jia Sun, Qiangang Fu   +5 more
doaj   +1 more source

Ablation state assessment of SF6 circuit breaker contacts based on BP neural network and mean impact value

Energy Reports, 2022
In order to evaluate the ablation state of the SF6 circuit breaker contacts, simulated ablation tests were carried out on the circuit breaker, and the dynamic resistance curve as a function of contact travel was measured with three levels of injected ...
Qiang Wu, Yu Wang, Yaoping Wang, Jian Wang, Lei Lan, Yeqiang Deng, Xishan Wen, Bing Luo, Wei Xiao   +8 more
doaj   +1 more source