Results 131 to 140 of about 5,756,230 (297)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

2024 multidisciplinary consensus on image‐guided lung tumor ablation from the Taiwan Academy of Tumor Ablation

Thoracic Cancer
In this article, the multidisciplinary team of the Taiwan Academy of Tumor Ablation, who have expertise in treating lung cancer, present their perspectives on percutaneous image‐guided thermal ablation (IGTA) of lung tumors. The modified Delphi technique
Ling Kai Chang, Shun Mao Yang, Ning Chien, Chao Chun Chang, Hsin Yueh Fang, Ming Cheng Liu, Kao Lun Wang, Wei Chan Lin, Frank Cheau Feng Lin, Cheng Yen Chuang, Po Kuei Hsu, Tsai Wang Huang, Chun Ku Chen, Yeun Chung Chang, Kai Wen Huang   +14 more
doaj   +1 more source

Plasma protein profiling analysis in patients with atrial fibrillation before and after three different ablation techniques. [PDF]

Front Cardiovasc Med, 2022
Lin M, Bao Y, Du Z, Zhou Y, Zhang N, Lin C, Xie Y, Zhang R, Li Q, Quan J, Zhu T, Xie Y, Xu C, Xie Y, Wei Y, Luo Q, Pan W, Wang L, Ling T, Jin Q, Wu L, Yin T, Xie Y.   +22 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Exploring novel techniques for ablation of cardiac arrhythmia:Challenges and opportunities [PDF]

This PhD thesis investigates innovative approaches to improve the efficacy and safety of catheter ablation for cardiac arrhythmia, adressing two key challenges: identification of arrhythmia mechanisms and creation of durable ablation lesions.Part I ...
Abeln, B.G.S.
core   +4 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Nanosecond ablation of alumina with an ytterbium fibre-laser: experimental study, topography and damage evaluation [PDF]

, 2014
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Programa de Pós-Graduação em Ciência e Engenharia de Materiais, Florianópolis, 2014.Abstract : The use of advanced ceramics has been limited by the high machining costs, with grinding and ...
Gomes, Diego Ribas
core  

Impact of Extended Use of Ablation Techniques in Cirrhotic Patients with Hepatocellular Carcinoma: A Cost-Effectiveness Analysis. [PDF]

Cancers (Basel), 2022
Ramtohul T, Vilgrain V, Soubrane O, Bouattour M, Luciani A, Kobeiter H, Mule S, Tacher V, Laurent A, Amaddeo G, Regnault H, Bulsei J, Nault JC, Nahon P, Durand-Zaleski I, Seror O.   +15 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Treatment outcomes and complications of percutaneous thermal ablation for subcapsular hepatocellular carcinoma

International Journal of Gastrointestinal Intervention
Background : To evaluate treatment efficacy and safety, local tumor progression-free survival (LTPFS), and risk factors for local tumor progression (LTP) after percutaneous thermal ablation for subcapsular hepatocellular carcinomas (HCCs), defined as ...
Thanita Limsiri, Akeanong Worakitsitisatorn, Preechapon Udomchaisakul, Atiya Faungsuwan   +3 more
doaj   +1 more source