Results 141 to 150 of about 5,756,230 (297)

Enhancement of skin permeability with thermal ablation techniques: concept to commercial products. [PDF]

Drug Deliv Transl Res, 2021
Parhi R, Mandru A.
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Aortic Regurgitation as a Complication of Electrophysiologic Ablation Techniques: A Narrative Review. [PDF]

Curr Cardiol Rev, 2021
Shehata E, Abdel-Samie MS, Elkoumy A, Yehia A, Soliman O, Abdelghani M.   +5 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Magnetocardiographic demonstration of complex ventricular preexcitation resulting in ablation failure

, 2013
The Wolff-Parkinson-White (WPW) syndrome affects 1 to 3 persons per 1000. Catheter ablation (CA) is nowadays proposed as the preferred therapy (with success in more than 90% of cases) and ECG is the most used non-invasive method for classification and ...
Brisinda, Donatella, Sorbo, Anna Rita, Venuti, Angela, Fenici, Riccardo   +3 more
core   +1 more source

Implications of RAS Mutations on Oncological Outcomes of Surgical Resection and Thermal Ablation Techniques in the Treatment of Colorectal Liver Metastases. [PDF]

Cancers (Basel), 2022
Rhaiem R, Rached L, Tashkandi A, Bouché O, Kianmanesh R.   +4 more
europepmc   +1 more source

Surgical Ablation Techniques

Atrial fibrillation is the most common arrhythmia affecting millions of people globally. The increasingly aging population and those with established cardiovascular risk factors (i.e., diabetes, obesity, hypertension, heart failure, and sleep apnea) are most susceptible to this arrhythmia and its dreaded complications. Although early detection, primary
openaire   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Comparison of Efficacy among Three Radiofrequency Ablation Techniques for Treating Knee Osteoarthritis: A Systematic Review and Meta-Analysis. [PDF]

Int J Environ Res Public Health, 2021
Chou SH, Shen PC, Lu CC, Liu ZM, Tien YC, Huang PJ, Chou CM, Shih CL.   +7 more
europepmc   +1 more source