Results 91 to 100 of about 3,414,706 (323)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Capabilities and ableism in early childhood education

peer reviewedIn this article, the authors discuss capabilities and ableism in early childhood education by drawing from the capabilities approach and ableism-critical perspectives.
PROYER, Michelle, More, Rahel
core   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Ableism a zjawisko infrahumanizacji "obcych" [PDF]

, 2016
The purpose of this article is to draw attention to the infrahumanisation phenomenon of Otherness in the context of ableism. In the discussion, a reference is made to the concept of infrahumanisation, explaining what its essence and characteristic ...
Bełza-Gajdzica, Magdalena
core  

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Részvétel és igazságosság – A posztszocializmus, a piacgazdaság és az épségizmus hatása a fogyatékossággal élő emberek társadalmi részvételére

Fogyatékosság és Társadalom
Contributing to disability studies in the post-socialist context (Mladenov, 2015, 2016), this paper explores the social injustices generated by the ableist environment.
Sára Csillag, Carmen Svastics, Zsuzsanna Győri, Anna Laura Hidegh   +3 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Structural ableism in public health and healthcare: a definition and conceptual framework

The Lancet Regional Health - Americas, 2023
Dielle J. Lundberg, Jessica A. Chen
semanticscholar   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Ableism as transformative practice

, 2014
[Introduction]: There has been an assortment of ways to think about and designate disability and corporeal difference. We are familiar with the biomedical approach and more recent concept of the social model of disability which links the designation ...
Campbell, Fiona Kumari
core