Results 41 to 50 of about 149,179 (300)

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source

Tropomyosin 1 Promotes Platelet Adhesion and Clot Contraction Separate from Its Roles in Developmental Hematopoiesis

Advanced Science, EarlyView.
ABSTRACT Genome‐wide association studies (GWAS) link the Tropomyosin 1 (Tpm1) locus to quantitative blood trait variation, but related mechanisms are unclear. Tpm1 encodes an actin‐binding protein that regulates actin filament diversity, cell adhesion, signaling, and actomyosin contractility.
Po‐Lun Kung, Victor Tsao, Alina D Peshkova, Oscar A. Marcos‐Contreras, Kim Ha, Brian M Dulmovits, Nkemdilim Okoli, Anvi Sinha, Gennadiy Fonar, Rong Qiu, Rolf D Bates, Janelle Yeboah, Carson Shalaby, Tyler Truex, Soomin Jeong, Edna C Hardeman, Peter W Gunning, Vladimir R Muzykantov, Jacob W Myerson, Christopher S Thom   +19 more
wiley   +1 more source

Structural study of hemoglobin Knossos, β27 (B9) Ala→Ser A new abnormal hemoglobin present as a silent β-thalassemia

, 1982
A new electrophoretically silent hemoglobin variant is described that produces the classical phenotype of β thalassemic intermedia in association with β° thalassemia trait. This variant has the expression of a silent β thalassemia trait.
Blouquit, Y., Komis, G., N. Arous, Sellaye, M., Loukopoulos, D., D. Loukopoulos, Y. Blouquit, Fessas, Ph., Ph. Fessas, J. Rosa, Boussiou, M., Galacteros, F., F. Galacteros, M. Sellaye, G. Komis, Arous, N., M. Boussiou, Rosa, J.   +17 more
core   +1 more source

Chromatographic and Chemical Studies of Some Abnormal Human Hemoglobins and of Some Minor Hemoglobin Components [PDF]

, 1961
Major and minor components in hemoglobins A, C, D, F, H, and S were detected and compared with one another by chromatography on IRC-50 resin. A procedure utilizing radioactive hemoglobins was developed for differentiating two hemoglobins with very ...
Jones, Richard Theodore
core   +1 more source

Organ‐Specific and Conserved Regulatory Logic Orchestrates Gene Expression in the Embryonic Mesothelium

Advanced Science, EarlyView.
Integrated multi‐omic profiling maps the gene‐regulatory landscape of the coelomic mesothelium across heart, lung, and pancreas. A cardiac‐restricted regulatory program is uncovered in which TBX20 activates heart mesothelial (epicardial) cis‐regulatory elements, while MAF emerges as a conserved regulator of mesothelial identity.
Quang Minh Dang, Nicola Smart, Andia Nicole Redpath, Joaquim Miguel Vieira   +3 more
wiley   +1 more source

Abnormal hemoglobin phenotypes in carriers of mild anemia in Latin America.

, 2010
We looked for abnormal hemoglobins in blood samples sent for diagnosis of anemia. Identification of the hemoglobins was made using electrophoretic, chromatographic and molecular procedures.
Zamaro, P. J., Bonini-Domingos, C. R.
core   +1 more source

Biomimetic Ru‐Mn Nanozyme with Cascade Catalytic Activity Attenuates Secondary Brain Injury in Intracerebral Hemorrhage

Advanced Science, EarlyView.
Ru–Mn composite nanozymes are engineered to mimic dual‐enzyme cascade catalysis, enabling efficient ROS clearance and neuroinflammation suppression. In collagenase‐ and autologous blood‐induced ICH mouse models, intranasal and intravenous administration reduced hematoma volume, preserved BBB integrity, and improved neurological recovery.
Zhongxin Duan, Peng Li, Yue Wang, Xin Qi, Wanyu Wang, Yongzhong Cheng, Huabin Zhang, Xin Hu, Xiang Gao   +8 more
wiley   +1 more source

A Simple Method for Detection of Chain Anomaly of Abnormal Hemoglobin in Hemolysate without Preliminary Purification [PDF]

, 1966
A new simple and rapid method for determining chain anomaly of abnormal hemoglobin was invented. Hemolysate, without preliminary separation and purification of the abnormal hemoglobin, is treated with p-chloromercuribenzoic acid (PCMB) in acidic solution,
Miyaji, Takaoki, Ohba, Yuzo, Shibata, Susumu   +2 more
core  

Prevalence of beta-Thalassemia Trait and Abnormal Hemoglobins in Sanliurfa Province in Southeast Turkey

, 2014
Thalassemia is one of the most common hereditary disorders in Turkey, especially in the Mediterranean region of the country. The purpose of this study was to determine the frequency of the beta-thalassemia (beta-thal) trait and abnormal hemoglobins (Hbs)

core   +1 more source

Pharmacologic Modulation of ARID3A with Rimegepant Reactivates Type I Interferon Signaling and Sensitizes Triple‐Negative Breast Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
This study identifies ARID3A as a key immunosuppressive transcription factor in TNBC. Its inhibition activates the type I IFN pathway, boosting CD8+ T cell infiltration and sensitizing tumors to anti‐PD‐1. The FDA‐approved migraine drug Rimegepant targets ARID3A, enhances immunotherapy efficacy in preclinical models, and establishes a druggable axis to
Teng Zhou, Yifei Zhu, Cheng Zeng, Jinlu Han, Huiying Huang, Doudou Li, Mingxi Lin, Yizi Jin, Qin Guo, Yuxin Yan, Xinhui Mao, Yifei Zhou, Jian Zhang   +12 more
wiley   +1 more source