Results 91 to 100 of about 1,794,315 (321)

Disrupting the Formation of YAP Condensates Promotes the Activation of AMPKα to Inhibit the Progression of Primary Liver Cancer

Advanced Science, EarlyView.
This study systematically investigates the function and molecular mechanisms of YAP phase separation in multiple primary liver cancers. These findings provide novel insights into phase separation‐mediated primary liver cancer development and validate targeted disruption of this process as an effective therapeutic strategy for primary liver cancer ...
Shuang‐Zhou Peng, Jia‐Jia Liang, Yun‐Feng Zhan, Wei‐Xun Wu, Wan‐Li Xu, Xiao‐Kun Zhang, Li‐Jun Cai, Fu‐Quan Jiang   +7 more
wiley   +1 more source

Dual Targeting of Tau Kinases and Autophagy by Abemaciclib Independent of CDK4/6 Inhibition

Advanced Science, EarlyView.
Abemaciclib rescues cognitive function and attenuates tau pathology in Alzheimer's disease models, but not through its known cancer‐fighting mechanism. This study demonstrates that abemaciclib operates independently of CDK4/6 inhibition, instead directly targeting tau kinases CaMKII and GSK3β while simultaneously promoting autophagic clearance of ...
Jihui Han, June‐Hyun Jeong, Dongjoon Lee, Yujin Jung, Yujin Jin, Eun Sun Jung, Haeng Jun Kim, Woo Youn Kim, Chang‐Han Lee, Inhee Mook‐Jung   +9 more
wiley   +1 more source

Acute lymphoblastic leukemia in a child with hemoglobins S and Q-Iran

The Turkish Journal of Pediatrics, 1990
A 13-year-old girl with acute lymphoblastic leukemia is presented. The peripheral smear showed, in addition to lymphoblasts, marked anisocytosis, poikilocytosis, and polychromasia. In vitro sickling test was positive. Hemoglobin electrophoresis at
A Gürgey, S Ozsoylu, G Hiçsönmez, G Irken, C Altay   +4 more
doaj  

Triagem neonatal para hemoglobinopatias: um estudo piloto em Porto Alegre, Rio Grande do Sul, Brasil Neonatal screening for hemoglobinopathies: a pilot study in Porto Alegre, Rio Grande do Sul, Brazil

Cadernos de Saúde Pública, 2002
Este estudo, tem como o objetivo determinar a freqüência das hemoglobinopatias em neonatos, que realizaram a coleta para o Teste de Triagem Neonatal para Distúrbios Metabólicos no Hospital de Clínicas de Porto Alegre.
Liane Esteves Daudt, Débora Zechmaister, Liliana Portal, Eurico Camargo Neto, Lúcia Mariano da Rocha Silla, Roberto Giugliani   +5 more
doaj   +1 more source

HB Setif [A94(Gi)Asp+Tyr] in Malta [PDF]

, 1997
Since testing of newborn infants for abnormal hemoglobins (Hbs) was reinitiated in Malta in 1989, about 20,000 cord blood samples have been studied with an isoelectrofocusing (IEF) technique (1). Among these, 2% have an abnormal Hb, i.e. 1.8% have a y-
Borg, Isabella, Felice, Alex, Fiorini, A., Valentino, Mario   +3 more
core  

Korelasi antara Gula Darah 2 Jam Postprandial Danhba1c di Laboratorium Klinik Graha Spesialis RSMH Palembang [PDF]

, 2014
Pemeriksaan gula darah merupakan pemeriksaan yang dilakukan untuk menegakkan diagnosis diabetes melitus. Hasil pemeriksaan gula darah pasien tidak cukup menggambarkan kondisi gula darah pasien, sehingga diperlukan pemeriksaan lain dengan menilai kadar ...
Habib, M. (Moh), Partan, R. U. (Radiyati), R, K. Y. (Kemas)   +2 more
core   +2 more sources

Decreased Erythrocyte Survival in Hemoglobin H Disease As a Result of the Abnormal Properties of Hemoglobin H: The Benefit of Splenectomy [PDF]

, 1961
Demetrios A. Rigas, Robert D. Koler, George H. Cummings, Marie L. Duerst, Donald R. Malm, Katherine Swisher, Patricia J. Vanbellinghen   +6 more
openalex   +1 more source

Ultrasound‐Boosted Liposomal Prodrug Overcomes Age‐Associated Biodistribution Disparity in Pediatric Solid Tumor Therapy

Advanced Science, EarlyView.
The age‐associated disparity of nanocarrier biodistribution limits the nanotherapeutics of childhood solid tumors. This study developed an ultrasound‐activated liposomal prodrug (CSCPTL) to overcome the age‐associated disparity of off‐target distribution.
Danfei Chen, Junjun Xu, Jian Chen, Jue Hu, Xiaobo Xuan, Haifang Cai, Mingdong Yang, Zhuxian Zhou, Guowei Wang   +8 more
wiley   +1 more source

Hemoglobin variants with electrophoretic mobility similar to hemoglobin S [PDF]

, 2017
9ª Reunião Científica da Sociedade Portuguesa de Medicina Laboratorial, 7-8 abril 2017Hemoglobinopathies are among the most common inherited diseases around the world and are one of the world’s major health problems.
Copeto, Sandra, Costa, Alcina, Costa, Sandra, Faustino, Paula, Gonçalves, João, Loureiro, Pedro, Miranda, Armandina, Seixas, Maria Teresa, Seuanes, Filomena   +8 more
core  

A Third Abnormal Hemoglobin Associated with Hereditary Hemolytic Anemia [PDF]

, 1951
Harvey A. Itano
openalex   +1 more source