Results 91 to 100 of about 1,740,227 (374)

A Self‐Assembling LYTAC Mediates CTGF Degradation and Remodels Inflammatory Tumor Microenvironment for Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
A CTGF‐LYTAC nanoplatform is developed to selectively degrade connective tissue growth factor (CTGF) in triple‐negative breast cancer (TNBC), inhibiting TGF‐β signaling and cell interactions in the tumor microenvironment (TME). This strategy effectively suppresses tumor growth and metastasis, outperforming antibody‐based therapy.
Jia‐Yi Lin, Ye Wu, Xiao‐Hui Liang, Min Tang, Xin Sun, Sheng‐Xin Lu, Jin‐Mei Jin, Xin Guo, Bei Wang, Hong‐Zhuan Chen, Wei‐Dong Zhang, Xin Luan   +11 more
wiley   +1 more source

Speciation in the baboon and its relation to gamma-chain heterogeneity and to the response to induction of HbF by 5-azacytidine [PDF]

, 1984
In the baboon (Papio species), the two nonallelic gamma-genes produce gamma-chains that differ at a minimum at residue 75, where isoleucine (I gamma-chain) or valine (V gamma) may be present.
DeSimone, Joseph, Espinueva, Zenaida, Hall, Lemuel, Huynh, Van, Schroeder, W. A., Shelton, J. Roger, Shelton, Joan B., Zwiers, David   +7 more
core  

Methemoglobin and Sulfhemoglobin Levels in Students of Walailak University

Walailak Journal of Science and Technology, 2011
Methemoglobin (MHb) and Sulfhemoglobin (SHb) are abnormal oxygen-carrying protein hemoglobins (Hbs) in blood circulation which can be used to represent the degree of pollution in the surrounding environment including air, food and drinks.
Uthai TRIAPIRUX, Prasit NA-EK, Chinnaphat KITTHIPONGVIVAT, Surachate CHALAJIT   +3 more
doaj   +1 more source

Enhanced Catalytic Cycle of Glucose Oxidation and Reactive Species with ROS and RHS Generation Mediated by Galvanic Engineering of Dual Atomic Sites on Covalent Organic Frameworks Demonstrating Synergistic Bimetal Tumor Treatment

Advanced Science, EarlyView.
A galvanic replacement is used to control dual atomic metals (Au and Ir) on a covalent organic framework (COF) nanoparticle and then coated with hyaluronic acid (HA). Under a specific bimetallic ratio (COF/Aux/Ir1‐x), the optimization can be achieved for the conversion of intracellular nutrients into reactive species (HOCl and O2• ─) and effectively ...
Wei‐Chung Pan, Cheng‐Hung Luo, Wen‐Ling Lin, Liu‐Chun Wang, Divinah Manoharan, Po‐Ya Chang, Hwo‐Shuenn Sheu, Chen‐Hao Yeh, Chia‐Jui Yen, Chen‐Sheng Yeh   +9 more
wiley   +1 more source

HB UBE-2 variant hemoglobin case detected during HBA1C measurement

Cukurova Medical Journal, 2021
Hemoglobin A1c is used in the diagnosis and the management of Diabetes Mellitus. The accuracy of hemoglobin A1c measurements may be affected by various factors and the most common interferences are variant hemoglobins.
Evin Kocatürk, Zeynep Kusku Kiraz, Şükrü Demir, Hava Üsküdar Teke, İ. Özkan Alataş, Oğuz Çilingir   +5 more
doaj  

FABP4 as a Mediator of Lipid Metabolism and Pregnant Uterine Dysfunction in Obesity

Advanced Science, EarlyView.
Obesity during late pregnancy contributes to uterine smooth muscle dysfunction, but the underlying mechanisms are unclear. This study identifies fatty acid binding protein 4 (FABP4) as a key player in the process, mediating excessive fatty acid uptake, lipid accumulation, and mitochondrial dysfunction in myometrial cells. FABP4 could be a novel uterine
Xuan Li, Huihui Yu, Ruixian Tian, Xingxing Wang, Ting Xing, Chenyi Xu, Tengteng Li, Xue Du, Qianqian Cui, Biao Yu, Yunxia Cao, Zongzhi Yin   +11 more
wiley   +1 more source

Prevalence and problem of hemoglobinopathy in the population of Lampang Province

Journal of Associated Medical Sciences, 2014
Objectives: To determine prevalence and problem of abnormal hemoglobins (Hbs) on interpreting hemoglobin (Hb) identification results in Lampang hospital. Materials and methods: PCR was performed to identify globin gene defects in 102 from 14,909 routine
Tiemjan Keowkarnkah
doaj  

De novo alpha 2 hemoglobin gene (HBA2) mutation in a child with hemoglobin M Iwate and symptomatic methemoglobinemia since birth

Revista Brasileira de Hematologia e Hemoterapia, 2014
Cyanosis in an apparently healthy newborn baby may be caused by hemoglobin variants associated with the formation of methemoglobin, collectively known as M hemoglobins.
Marcos Borato Viana, André Rolim Belisário   +1 more
doaj   +1 more source

Mechanical Biomimetic Nanocomposites for Multidimensional Treatment of Arterial Thrombosis

Advanced Science, EarlyView.
In this study, a mechanical biomimetic nanocomposite is developed, guided by photoacoustic imaging, to achieve highly efficient and safe thrombolysis through the synergistic effects of photothermal therapy and pharmacological intervention. Most notably, the nanoparticle improves the microenvironment of arterial thrombi, marked by high shear stress and ...
Ying Li, Qi Xiang, Yan Zhang, Fuxue Luo, Yunfang Wu, Haitao Ran, Yang Cao   +6 more
wiley   +1 more source

Spin Label Studies of the Hemoglobin–Membrane Interaction During Sickle Hemoglobin Polymerization [PDF]

, 2010
An enhanced hemoglobin–membrane association has been previously documented in sickle cell anemia. However, it is not known how this interaction is modified during the hemoglobin S polymerization process.
Falcón Dieguez, Jose, Gennaro, Ana Maria, Lores Guevara, Manuel, Rodi, Pablo Marcelo   +3 more
core   +1 more source