Results 1 to 10 of about 46,666 (209)
Journal of Pathology of Nepal, 2013 Background: Sickle Hemoglobin is the most common pathological hemoglobin mutation worldwide which forms sickle shape or elongated forms on deoxygenation.
A Shrestha, S Karki
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Elastic property of sickle and normal hemoglobin protein: Molecular dynamics
AIP Advances, 2022 This work focuses on identifying the conformational stability and binding components in sickle and normal hemoglobin to explore the elastic properties and realize the stiffness by using molecular dynamics simulation. Our investigation shows that a larger
Jhulan Powrel, Narayan Prasad Adhikari
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The Microrheology of Sickle Hemoglobin Gels [PDF]
Biophysical Journal, 2010 Sickle cell disease is a rheological disease, yet no quantitative rheological data exist on microscopic samples at physiological concentrations. We have developed a novel method for measuring the microrheology of sickle hemoglobin gels, based on magnetically driven compression of 5- to 8-microm-thick emulsions containing hemoglobin droplets ...
Zakharov, Mikhail N. +3 more
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Nonideality and the Nucleation of Sickle Hemoglobin [PDF]
Biophysical Journal, 2000 The homogeneous and heterogeneous nucleation kinetics of sickle hemoglobin (HbS) have been studied for various degrees of solution crowding by substitution of cross-linked hemoglobin A, amounting to 50% of the total hemoglobin. By cross-linking hemoglobin A, hybrid formation between hemoglobin A and hemoglobin S was prevented, thus simplifying the ...
Ivanova, Maria +4 more
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BMC Biology, 2023 Background Intracellular hemoglobin polymerization has been supposed to be the major determinant for the elevated rigidity/stiffness of sickle erythrocytes from sickle cell anemia (SCA) patients.
Kun Wang +5 more
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Journal of Applied Hematology, 2022 BACKGROUND: Sickle cell disease and its variants result from an abnormal hemoglobin, hemoglobin S (HbS), caused by a single point mutation in the Beta-Globin gene.
Hareem Alam, Natasha Ali
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Thermal properties of normal and sickled hemoglobin protein
Bibechana, 2021 Thermodynamic properties of sickled and normal hemoglobin protein are considered within the framework of classical molecular dynamics. Here we have studied the specific heat capacity and RMSD (Root Mean Square Deviation) of both types of hemoglobin ...
Jhulan Powrel, Narayan P Adhikari
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Frontiers in Medicine, 2022 Sickle cell disease (SCD) is a heterogeneous group of inherited disorders characterized by the production of sickle hemoglobin which is less soluble than an adult or fetal hemoglobin.
Awni Alshurafa, Mohamed A. Yassin
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Sickle Hemoglobin: A Specific Radioimmunoassay [PDF]
Blood, 1974 Abstract For the quantitation of hemoglobin S, a radioimmunoassay has been developed which is specific and highly sensitive. Hemoglobin S was purified by column chromatography and injected with complete Freund’s adjuvant into goats.
P T, Rowley +3 more
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Candidate sequence variants and fetal hemoglobin in children with sickle cell disease treated with hydroxyurea. [PDF]
PLoS ONE, 2013 Fetal hemoglobin level is a heritable complex trait that strongly correlates swith the clinical severity of sickle cell disease. Only few genetic loci have been identified as robustly associated with fetal hemoglobin in patients with sickle cell disease,
Nancy S Green +12 more
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