Results 11 to 20 of about 46,727 (267)

Natural History of Chronic Kidney Disease in Sickle Cell Disease. [PDF]

Am J Hematol
ABSTRACT Kidney complications, referred to as nephropathy, develop early in sickle cell disease (SCD). In addition to its known morbidity, abundant data show that chronic kidney disease (CKD) is associated with an increased mortality risk in SCD. Increasing evidence suggests that the natural history of SCD nephropathy is progressive. Initial glomerular
Ataga KI.
europepmc   +2 more sources

Hematologic and hemorheological determinants of resting and exercise-induced hemoglobin oxygen desaturation in children with sickle cell disease

Haematologica, 2013
The aim of the study was to determine the factors associated with resting and exercise-induced hemoglobin oxygen desaturation. The well-established six-minute walk test was conducted in 107 sickle cell children (50 with sickle hemoglobin C disease and 57
Xavier Waltz, Marc Romana, Marie-Laure Lalanne-Mistrih, Roberto F. Machado, Yann Lamarre, Vanessa Tarer, Marie-Dominique Hardy-Dessources, Benoît Tressières, Lydia Divialle-Doumdo, Marie Petras, Frederic Maillard, Maryse Etienne-Julan, Philippe Connes   +12 more
doaj   +1 more source

Study on HemoTypeSC™ test for the rapid screening of sickle cell disease patients in Government Medical College and Hospital, Ambikapur

Asian Journal of Medical Sciences, 2022
Background: Sickle cell disease (SCD), also known as sickle cell anemia, is a dangerous disease in which the body produces an abnormal form of hemoglobin, the protein in red blood cells that transport oxygen throughout the body. The body produces sickle-
Salma Mahaboob R , Obulesu G , Rajesh Kumar Srivastava , Murthy R , Parmanand Agarwal , Arya R C   +5 more
doaj   +1 more source

Perspective: A novel prognostic for sickle cell disease

Saudi Journal of Medicine and Medical Sciences, 2018
Sickle hemoglobin (α2βS2) polymerization drives disease pathophysiology in sickle cell anemia. Fetal hemoglobin (α2γ2) restricts disease severity by inhibiting the polymerization of sickle hemoglobin in a concentration-dependent manner. Clinical decision-
Brian M Mozeleski, Abdullah Al-Rubaish, Amein Al-Ali, Jose Romero   +3 more
doaj   +1 more source

The Growth of Sickle Hemoglobin Polymers [PDF]

Biophysical Journal, 2011
The measurement of polymer growth is an essential element in characterization of assembly. We have developed a precise method of measuring the growth of sickle hemoglobin polymers by observing the time required for polymers to traverse a photolytically produced channel between a region in which polymers are created and a detection region.
Aprelev, Alexey, Liu, Zenghui, Ferrone, Frank A.   +2 more
openaire   +2 more sources

Targeting sickle cell disease root-cause pathophysiology with small molecules

Haematologica, 2019
The complex, frequently devastating, multi-organ pathophysiology of sickle cell disease has a single root cause: polymerization of deoxygenated sickle hemoglobin.
Yogen Saunthararajah
doaj   +1 more source

Safety and efficacy of blood exchange transfusion for priapism complicating sickle cell disease. [PDF]

, 2016
BACKGROUND: Priapism is unwanted painful penile erection that affects about 36% of boys and men with sickle cell disease (SCD) most of whom have sickle cell anemia. Clinically, priapism could be stuttering, minor, or major.
Adeyoju, Ayache, Ballas, Ballas, Baron, Betke, Charache, Eckman, Emond, Harms, Janes, Mantadakis, Okpala, Powars, Rackoff, Rogers, Seeler, Serjeant, Serjeant, Sharpsteen, Siegel, Talacki, Teixeira, US Department of Health and Human Services   +23 more
core   +2 more sources

Stroke From Paradoxical Embolism in a Young Patient With Sickle-Cell Disease and High Fetal Hemoglobin: A Diagnostic Challenge. [PDF]

Clin Case Rep
Acute infarcts and microvascular ischemic changes in the brain of a young patient with Sickle‐Cell Disease despite High Fetal Hemoglobin. ABSTRACT Sickle‐cell disease (SCD) is characterized by abnormal hemoglobin (Hb) polymerization, leading to erythrocyte sickling and microvascular obstruction.
Luo YH, Zuberi N, Rizzolo A, Warner M, Isnard S, Routy JP.   +5 more
europepmc   +2 more sources

Prevalence of Inherited Hemoglobin Disorders and Relationships with Anemia and Micronutrient Status among Children in Yaoundé and Douala, Cameroon. [PDF]

, 2017
Information on the etiology of anemia is necessary to design effective anemia control programs. Our objective was to measure the prevalence of inherited hemoglobin disorders (IHD) in a representative sample of children in urban Cameroon, and examine the ...
Brown, Kenneth H, Engle-Stone, Reina, Gimou, Marie-Madeleine, Green, Ralph, Nankap, Martin, Ndjebayi, Alex, Oyono, Yannick, Tarini, Ann, Williams, Thomas N   +8 more
core   +1 more source

Sickle Cell Anemia, the First Molecular Disease: Overview of Molecular Etiology, Pathophysiology, and Therapeutic Approaches

The Scientific World Journal, 2008
The root cause of sickle cell disease is a single β-globin gene mutation coding for the sickle β-hemoglobin chain. Sickle hemoglobin tetramers polymerize when deoxygenated, damaging the sickle erythrocyte.
Martin H. Steinberg
doaj   +1 more source