The post-mortem diagnosis of vasocclusive crisis in sickle cell disease
Autopsy and Case Reports, 2014 Sickle cell disease (SCD) comprises a group of genetic blood disorders that affect the hemoglobin molecular structure, and in some cases, the association with hemoglobin synthesis.
Varsha Bhatia +2 more
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Structure of Sickled Erythrocytes and of Sickle-Cell Hemoglobin Fibers [PDF]
Proceedings of the National Academy of Sciences, 1973 Deoxyhemoglobin from patients homozygous for sickle-cell anemia (deoxyhb S) aggregates into long straight fibers. These may extend through most of the length of the sickled cell, forming either square or hexagonally packed bundles with lattice constants of 170-180 Å. Each fiber is a tube made up of six thin filaments, which are wound around the tubular
J T, Finch +3 more
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The Evolving Pharmacotherapeutic Landscape for the Treatment of Sickle Cell Disease. [PDF]
, 2020 Sickle cell disease (SCD) is an extremely heterogeneous disease that has been associated with global morbidity and early mortality. More effective and inexpensive therapies are needed.
Ballas, Samir K
core +1 more source
Prevalence of hemoglobin abnormalities in an apparently healthy population in Benin
Hematology, Transfusion and Cell Therapy, 2020 Background: Sickle cell disease is the most common monogenic disorder in humans and is a major public health concern in sub-Saharan Africa. In Benin, the prevalence of sickle cell disease is estimated to be 4.8%.
Alban Zohoun +3 more
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Revista Brasileira de Hematologia e Hemoterapia, 2012 BACKGROUND: Sickle cell disease is a hemoglobinopathy characterized by hemolytic anemia, increased susceptibility to infections and recurrent vaso-occlusive crises that reduces the quality of life of sufferers.
Darcielle Bruna Dias Elias +5 more
doaj +1 more source
Comorbidities in aging patients with sickle cell disease. [PDF]
, 2018 Sickle cell disease (SCD) in general and sickle cell anemia in particular is a highly complex disorder both at the molecular and clinical levels. Although the molecular lesion is a single-point mutation, the sickle gene is pleiotropic in nature causing ...
Ballas, Samir K.
core +2 more sources
Of pools, oceans, and the Dead Sea. [PDF]
, 2017 In a comprehensive study in this issue of Blood, Carden and colleagues describe the importance of the tonicity of IV fluids used in the treatment of patients with sickle cell disease (SCD) during vaso-occlusive crises (VOCs).
Ballas, Samir K.
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Acetylation of Sickle Cell Hemoglobin by Aspirin [PDF]
Proceedings of the National Academy of Sciences, 1973 Incubation of HbS (or HbA) with aspirin leads to incorporation of acetyl groups into the protein. Incorporation was followed by the use of aspirin labeled with 14 C in the acetyl group. The acetylated hemoglobins show an increase in oxygen affinity compared to the parent proteins. If acetylation also occurs
I M, Klotz, J W, Tam
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Whole transcriptome analysis of human erythropoietic cells during ontogenesis suggests a role of VEGFA gene as modulator of fetal hemoglobin and pharmacogenomic biomarker of treatment response to hydroxyurea in β-type hemoglobinopathy patients [PDF]
, 2017 Background: Human erythropoiesis is characterized by distinct gene expression profiles at various developmental stages. Previous studies suggest that fetal-to-adult hemoglobin switch is regulated by a complex mechanism, in which many key players still ...
Ali, Bassam R. +11 more
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Reaching Community Through School Going Children for Sickle Cell Disease in Zankhvav Village of Surat District, Western India [PDF]
, 2012 Objectives: The objective of the study was to explore a method to reach the community via school going adolescents for screening tribal people for Sickle Cell disease.
Bansal, R +4 more
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