Results 31 to 40 of about 29,542 (277)

Sickle cell disease retinopathy: characterization among pediatric and teenage patients from northeastern Brazil

Revista Brasileira de Hematologia e Hemoterapia, 2014
Objective: The aim of the present study was to characterize sickle cell disease retinopathy in children and teenagers from Bahia, the state in northeastern Brazil with the highest incidence and prevalence of sickle cell disease.
Dayse Cury de Almeida Oliveira, Magda O.S. Carvalho, Valma Maria Lopes do Nascimento, Flávia Silva Villas-Bôas, Bernardo Galvão-Castro, Marilda Souza Goncalves   +5 more
doaj   +1 more source

Partial Red Blood Cell Exchange in Children and Young Patients with Sickle Cell Disease: Manual Versus Automated Procedure

Acta Médica Portuguesa, 2017
Introduction: The benefits of manual versus automated red blood cell exchange have rarely been documented and studies in young sickle cell disease patients are scarce. We aim to describe and compare our experience in these two procedures.
Carlos Escobar, Marta Moniz, Pedro Nunes, Clara Abadesso, Teresa Ferreira, António Barra, Anabela Lichtner, Helena Loureiro, Alexandra Dias, Helena Almeida   +9 more
doaj   +1 more source

The post-mortem diagnosis of vasocclusive crisis in sickle cell disease

Autopsy and Case Reports, 2014
Sickle cell disease (SCD) comprises a group of genetic blood disorders that affect the hemoglobin molecular structure, and in some cases, the association with hemoglobin synthesis.
Varsha Bhatia, Richa Juneja, Vijay Juvekar   +2 more
doaj   +1 more source

A clinico-hematological study of sickle cell disease among adult patients in Makkah, Saudi Arabia. [PDF]

Al-Azhar International Medical Journal, 2023
Background: Sickle cell disease is an autosomal recessive disease characterized by aberrant production of hemoglobin S (HbS). The clinical picture includes hemolytic anemia, vascular occlusion events, acute and persistent pain, and varied organ damage ...
Ahmad Arbaeen
doaj   +1 more source

Structure of Sickled Erythrocytes and of Sickle-Cell Hemoglobin Fibers [PDF]

Proceedings of the National Academy of Sciences, 1973
Deoxyhemoglobin from patients homozygous for sickle-cell anemia (deoxyhb S) aggregates into long straight fibers. These may extend through most of the length of the sickled cell, forming either square or hexagonally packed bundles with lattice constants of 170-180 Å. Each fiber is a tube made up of six thin filaments, which are wound around the tubular
J T, Finch, M F, Perutz, J F, Bertles, J, Döbler   +3 more
openaire   +2 more sources

Prevalence of hemoglobin abnormalities in an apparently healthy population in Benin

Hematology, Transfusion and Cell Therapy, 2020
Background: Sickle cell disease is the most common monogenic disorder in humans and is a major public health concern in sub-Saharan Africa. In Benin, the prevalence of sickle cell disease is estimated to be 4.8%.
Alban Zohoun, Tatiana Baglo Agbodande, Lutécia Zohoun, Ludovic Anani   +3 more
doaj   +1 more source

Hepatic Enzyme Abnormalities and Their Association With Hematological Parameters in Sickle Cell Disease: A Case-Control Study in Cameroon. [PDF]

Health Sci Rep
ABSTRACT Background and Aims The polymerization of deoxygenated hemoglobin S, resulting from a genetic mutation in sickle cell disease (SCD), leads to damage in multiple organs, including renal, cardiopulmonary, and cerebrovascular systems. The liver is also commonly affected, resulting in “sickle cell liver disease,” which may lead to progressive ...
Simo JL, Angandji PT, Tuono RM, Njinjou KF, Yong IWS, Njopwouo MS, Chuisseu PDD.   +6 more
europepmc   +2 more sources

Haptoglobin and sickle cell polymorphisms and risk of active trachoma in Gambian children. [PDF]

, 2010
BACKGROUND: Susceptibility and resistance to trachoma, the leading infectious cause of blindness, have been associated with a range of host genetic factors.
Doherty, CP, Andrew M Prentice, Martin J. Holland, Hennig, Branwen J, Bailey Robin, Kirk A Rockett, Fulford Anthony J., Kwiatkowski, DP, Fulford, AJ, Sharon E. Cox, Kwiatkowski, Dominic, Dominic P Kwiatkowski, Kwiatkowski Dominic P., Kirk A. Rockett, Sharon E Cox, Rockett, KA, Hennig Branwen J., Fulford, Anthony J, Dominic P. Kwiatkowski, Holland, MJ, Holland, Martin J, Cox, Sharon E, Mathilde Savy, Holland Martin J., Robin Bailey, Prentice, AM, Sirugo, G, Martin J Holland, Prentice, Andrew M, Anthony J Fulford, Sirugo, Giorgio, Bailey, Robin, Savy Mathilde, Conor P Doherty, Rockett, Kirk A, Bailey, R, Branwen J Hennig, Cox Sharon E., Doherty, Conor P, Cox, SE, Savy, M, Rockett Kirk A., Andrew M. Prentice, Prentice Andrew M., Anthony J. Fulford, Hennig, BJ, Conor P. Doherty, Sirugo Giorgio, Savy, Mathilde, Doherty Conor P., Branwen J. Hennig, Kwiatkowski, Dominic P, Giorgio Sirugo   +52 more
core   +1 more source

Correlation of low levels of nitrite and high levels of fetal hemoglobin in patients with sickle cell disease at baseline

Revista Brasileira de Hematologia e Hemoterapia, 2012
BACKGROUND: Sickle cell disease is a hemoglobinopathy characterized by hemolytic anemia, increased susceptibility to infections and recurrent vaso-occlusive crises that reduces the quality of life of sufferers.
Darcielle Bruna Dias Elias, Lilianne Brito da Silva Rocha, Maritza Barbosa Cavalcante, Alano Martins Pedrosa, Izabel Cristina Bandeira Justino, Romélia Pinheiro Gonçalves   +5 more
doaj   +1 more source

Acetylation of Sickle Cell Hemoglobin by Aspirin [PDF]

Proceedings of the National Academy of Sciences, 1973
Incubation of HbS (or HbA) with aspirin leads to incorporation of acetyl groups into the protein. Incorporation was followed by the use of aspirin labeled with 14 C in the acetyl group. The acetylated hemoglobins show an increase in oxygen affinity compared to the parent proteins. If acetylation also occurs
I M, Klotz, J W, Tam
openaire   +2 more sources