Results 21 to 30 of about 29,542 (277)

Fiber depolymerization [PDF]

, 2006
Depolymerization is, by definition, a crucial process in the reversible assembly of various biopolymers. It may also be an important factor in the pathology of sickle cell disease.
Turner, Matthew S., Ferrone, F.A., Agarwal, G., Wang, J.C., Jones, C. W., Kwong, S., Briehl, R. W., Briehl, R.W., Wang, J. C., Ferrone, F. A., Josephs, R., Jones, C.W., Turner, M.S.   +12 more
core   +1 more source

Hematological and Genetic Predictors of Daytime Hemoglobin Saturation in Tanzanian Children with and without Sickle Cell Anemia. [PDF]

, 2013
Low hemoglobin oxygen saturation (SpO2) is common in Sickle Cell Anemia (SCA) and associated with complications including stroke, although determinants remain unknown.
Cox, Sharon E, Newton, Charles R, Makani, Julie, Prentice, Andrew M, Kirkham, Fenella J   +4 more
core   +1 more source

Sickle Cell Anemia, the First Molecular Disease: Overview of Molecular Etiology, Pathophysiology, and Therapeutic Approaches

The Scientific World Journal, 2008
The root cause of sickle cell disease is a single β-globin gene mutation coding for the sickle β-hemoglobin chain. Sickle hemoglobin tetramers polymerize when deoxygenated, damaging the sickle erythrocyte.
Martin H. Steinberg
doaj   +1 more source

Feasibility Study of the “HemoTypeSC” Test for the Rapid Screening of Sickle Cell Disease in Côte D’Ivoire

Advances in Hematology, 2021
Sickle cell disease is a hereditary disease that predominantly affects black people. It is very widespread in sub-Saharan Africa, particularly at the Lehmann “sickle belt” level, where the prevalence of the hemoglobin S involves at least 10% of the ...
Jeannette Bassimbié Kakou Danho, Yao Nicaise Atiméré, Daouda Koné, Donafologo Daouda Yéo, Line Couitchéré   +4 more
doaj   +1 more source

Prevalence of Haemoglobine s in Araraquara-SP Population.

Revista Brasileira Multidisciplinar - ReBraM /Brazilian Multidisciplinay Journal, 2015
The Sickle Cell Anemia is a genetic hemoglobionopathy, characterized by an alteration in the hemoglobin molecule struture (HbA1), called hemoglobin S (HbS), which causes a distortion in the erythocytes structure, changing from spherical shape to sickle ...
Bruno Rocha de Jesus, Heloise Brait Rin, Elza Regina Manzolli Leite, Amauri Antiquera Leite, Miriane da Costa Gileno   +4 more
doaj   +1 more source

An immune basis for malaria protection by the sickle cell trait. [PDF]

, 2005
BACKGROUND: Malaria resistance by the sickle cell trait (genotype HbAS) has served as the prime example of genetic selection for over half a century. Nevertheless, the mechanism of this resistance remains the subject of considerable debate.
Alexander, ND, Kortok, M, Wambua, S, Kevin Marsh, David J Weatherall, Snow, Robert, Roberts, DJ, Moses Kortok, Wambua, Sammy, Mwangi, TW, Thomas N Williams, Williams, TN, Mwangi, Tabitha W., Mwangi Tabitha W, Snow, Robert W, Weatherall, David J., Weatherall David J, Williams, Thomas N., Marsh Kevin, Snow, RW, Alexander, Neal D, Robert W Snow, Marsh, K, Weatherall, David J, Snow, Robert W., Wambua Sammy, Snow Robert W, Williams Thomas N, Roberts, David J, Weatherall, DJ, David J Roberts, Alexander Neal D, Williams, Thomas N, Tabitha W Mwangi, Mwangi, Tabitha W, Roberts, David J., Kortok Moses, Neal D Alexander, Williams, Thomas, Kortok, Moses, Marsh, Kevin, Alexander, Neal D., Sammy Wambua, Roberts David J   +43 more
core   +1 more source

Hemorheological risk factors of acute chest syndrome and painful vaso-occlusive crisis in children with sickle cell disease

Haematologica, 2012
Background Little is known about the effects of blood rheology on the occurrence of acute chest syndrome and painful vaso-occlusive crises in children with sickle cell anemia and hemoglobin SC disease.Design and Methods To address this issue, steady ...
Yann Lamarre, Marc Romana, Xavier Waltz, Marie-Laure Lalanne-Mistrih, Benoît Tressières, Lydia Divialle-Doumdo, Marie-Dominique Hardy-Dessources, Jens Vent-Schmidt, Marie Petras, Cedric Broquere, Frederic Maillard, Vanessa Tarer, Maryse Etienne-Julan, Philippe Connes   +13 more
doaj   +1 more source

THE STATE OF HEMOGLOBIN IN SICKLED ERYTHROCYTES [PDF]

The Journal of Experimental Medicine, 1966
Electron microscopic and other evidence have provided support for the hypothesis that the sickling phenomenon is due to the intracellular formation of long slender crystals of reduced sickle hemoglobin. The rapid growth of these crystals causing tenting of the cell membrane is responsible for the bizarre distortion of the erythrocytes and presumably ...
openaire   +2 more sources

Global Burden of Sickle Cell Anaemia in Children under Five, 2010-2050: Modelling Based on Demographics, Excess Mortality, and Interventions [PDF]

, 2013
The global burden of sickle cell anaemia (SCA) is set to rise as a consequence of improved survival in high-prevalence low- and middle-income countries and population migration to higher-income countries.
Gupta, Sunetra, Gupta Sunetra, Piel, Frederic, Gupta, S, Weatherall, DJ, Thomas N. Williams (34879), Frédéric B Piel, David J Weatherall, Hay, SI, Weatherall, David, Sunetra Gupta (42432), Hay Simon I., Sunetra Gupta, David J. Weatherall (434017), Thomas N Williams, Simon I. Hay (82582), Williams, TN, Hay, Simon, Piel Frédéric B., Simon I Hay, Weatherall David J., Frédéric B. Piel (120380), Piel, FB, Williams Thomas N.   +23 more
core   +1 more source

Sickle Retinopathy in a Person with Hemoglobin S/New York Disease

Case Reports in Genetics, 2012
A patient who presented with sickle retinopathy and hemoglobin electrophoresis results compatible with sickle cell trait was found, on further investigation, to be a compound heterozygote with hemoglobin S and hemoglobin New York disease.
Donovan Calder, Maryse Etienne-Julan, Marc Romana, Naomi Watkins, Jennifer M. Knight-Madden   +4 more
doaj   +1 more source