Results 101 to 110 of about 1,794,315 (321)
Advanced Science, EarlyView.This study reveals that photothermal therapy, while inducing immunogenic cell death in triple‐negative breast cancer, paradoxically activates the oncogenic mTOR pathway to drive immune evasion. To counter this, a smart nanocomposite is engineered to co‐deliver localized hyperthermia and mTOR inhibition.
Yujie Zhao +13 more
wiley +1 more source
Spin Label Studies of the Hemoglobin–Membrane Interaction During Sickle Hemoglobin Polymerization [PDF]
, 2010 An enhanced hemoglobin–membrane association has been previously documented in sickle cell anemia. However, it is not known how this interaction is modified during the hemoglobin S polymerization process.
Falcón Dieguez, Jose +3 more
core +1 more source
Combinations of β chain abnormal hemoglobins with each other or with β-thalassemia determinants with known mutations: influence on phenotype [PDF]
, 1997 Titus H.J. Huisman
openalex +1 more source
Advanced Science, EarlyView.Nap1l4a is required in erythropoiesis and hypoxia responses via physical interaction with Klf1 and Scl to recruit the histone variant H2A.Z. This facilitates its associated cis‐regulatory element (CRE) remodeling and the consequent chromatin assembly, and activates the transcription of erythroid lineage‐specific genes.
JiaHao Shi +10 more
wiley +1 more source
Hemoglobin Himeji and inconsistent hemoglobin A1c values: a case report
Journal of Medical Case Reports, 2017 Background Hemoglobin A1c is used to evaluate the glycemic control in patients with diabetes and is a risk marker for chronic complications of diabetes. Hemoglobin variants are reported to falsely lower or increase hemoglobin A1c test results. We present
Vânia Guedes +5 more
doaj +1 more source
Evolution of placental function in mammals:the molecular basis of gas and nutrient transfer, hormone secretion, and immune responses [PDF]
, 2012 Placenta has a wide range of functions. Some are supported by novel genes that have evolved following gene duplication events while others require acquisition of gene expression by the trophoblast.
Carter, Anthony Michael
core +1 more source
Advanced Science, EarlyView.This study shows that Salmonella VNP20009 recruits pro‐tumor neutrophils that reduce its anticancer efficacy. Combining VNP with amodiaquine selectively eliminates these neutrophils by targeting glutathione reductase. A GR‐shRNA‐loaded VNP strain was further developed, demonstrating an innovative strategy integrating drug repurposing with synthetic ...
Wanfa Dong +13 more
wiley +1 more source
Atlas of protein sequence and structure [PDF]
Atlas of protein sequence and ...
Chang, M. A. +3 more
core +1 more source
Targeting DESI2 as a Novel Therapeutic Strategy for JAK2‐Mutant Leukemias
Advanced Science, EarlyView.Mass spectrometry‐based proteomics identify DESI2 as a novel component of the JAK2‐V617F complex, which associates with and stabilizes mutant JAK2 through deSUMOylation and deubiquitination, therefore promoting JAK2 mutant cell growth and MPN disease onset in vivo.
Husheng Mei +32 more
wiley +1 more source