Results 131 to 140 of about 1,740,227 (374)

Multifunctional Framework Nucleic Acid Vehicle for Antibiotic Sensitization and Treatment of Methicillin‐Resistant Staphylococcus aureus

open access: yesAggregate, EarlyView.
A self‐assembling, aggregation‐enhanced tetrahedral DNA nanostructure (tFNA), termed TACs, enables localized accumulation and sustained release of ceftriaxone while co‐delivering antisense oligonucleotides that silence mecA, reduce PBP2a expression, and restore β‐lactam susceptibility in MRSA.
Yicheng Zhao   +10 more
wiley   +1 more source

Hemoglobinopathies: peripheral blood analysis from academics of a university in Alfenas - MG [PDF]

open access: yes, 2020
The human hemoglobins (Hb) are globular tetramers formed by combination of two polypeptide chains of “type α” with two chains of “type β”, being Hb A1, Hb A2 and Fetal Hb the main types of hemoglobins in normal adult.
Batista, Gabriela Silva   +4 more
core   +1 more source

Cross‐Linked Protein Crystals With an Intense Nonconventional Full‐Color Photoluminescence Originating From Through‐Space Intermolecular Interaction

open access: yesAggregate, EarlyView.
Cross‐linked protein crystals are introduced as a novel class of nontraditional luminescent materials (NLMs) exhibiting tunable full‐color photoluminescence. Three polymorphic lysozyme crystals establish a clear, definitive structure–emission relationship, revealing that emission originates from intermolecular through‐space interactions (TSI).
Renbin Zhou   +7 more
wiley   +1 more source

Solving the Amyloid Paradox: Unveiling the Complex Pathogenicity of Amyloid Fibrils

open access: yesAggregate, EarlyView.
This review addresses the gap between strong evidence for the involvement of amyloid fibrils in neurodegeneration and the failure of anti‐amyloid therapies, a phenomenon herein termed the “amyloid paradox.” To address this paradox, we provide a comprehensive summary of the current understanding of fibrils' pathogenic properties and mechanisms ...
Maksim I. Sulatsky   +3 more
wiley   +1 more source

Primer caso de hemoglobina Köln (codon98 GTG>ATG) en Costa Rica First case of hemoglobin Köln (codon98 GTG>ATG) in Costa Rica

open access: yesActa Médica Costarricense, 2010
La exposición a ciertos medicamentos puede provocar anemia hemolítica con presencia de cuerpos de Heinz en sangre periférica. Esta anemia puede presentarse por sobredosis de medicamentos, tanto en individuos sanos como en personas con deficiencias ...
Walter Cartín   +7 more
doaj  

Deep‐Learning Model for Central Nervous System Infection Diagnosis and Prognosis Using Label‐Free 3D Immune‐Cell Morphology in the Cerebrospinal Fluid

open access: yesAdvanced Intelligent Systems, EarlyView.
Early diagnosis and prognosis prediction of central nervous system infections are critical. This study introduces a deep‐learning model utilizing cerebrospinal fluid immune‐cell morphology captured via 3D holotomography. The model effectively predicts infection etiology and prognosis, achieving high accuracy.
Bo Kyu Choi   +5 more
wiley   +1 more source

First Observation of Hemoglobin San Diego, a High Oxygen Affinity Hemoglobin Variant, in Turkey

open access: yesTurkish Journal of Hematology, 2017
Ebru Yılmaz Keskin   +5 more
doaj   +1 more source

Is Hemoglobin Variant Analysis Helpful in the Diagnostic Work-up of Patients Revealing Microcytic Erythrocytosis on Complete Blood Count? [PDF]

open access: yes, 2015
Introduction: Microcytic erythrocytosis is an abnormal CBC (complete blood count) finding that is under-recognized, poorly understood, and consequently under-utilized in patient care. It is characterized by decreased MCV and increased RBC count.
Dulau-Florea, Alina   +3 more
core   +1 more source

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