Results 31 to 40 of about 1,740,227 (374)

Identificação e caracterização de variantes novas e raras da hemoglobina humana Identification of characterization of novel and rare variants of human hemoglobin

Revista Brasileira de Hematologia e Hemoterapia, 2008
As anormalidades estruturais da hemoglobina estão entre as doenças genéticas mais comumente encontradas nas populações humanas. O Laboratório de Hemoglobinopatias do Departamento de Patologia Clínica da Faculdade de Ciências Médicas da Universidade ...
Elza M. Kimura, Denise M. Oliveira, Susan E. D. C. Jorge, Cristina F. Abreu, Dulcinéia M. Albuquerque, Fernando F. Costa, Maria de Fátima Sonati   +6 more
doaj   +1 more source

Heterozigose para hemoglobinopatias em doadores de sangue do Centro de Hemoterapia de Sergipe Heterozigosity to hemoglobinopathies in blood donors from the Hemotherapy Center in Sergipe, NE-Brazil

Revista Brasileira de Hematologia e Hemoterapia, 2006
As hemoglobinopatias, distúrbios geneticamente determinados da hemoglobina (Hb) humana, estão presentes com freqüência elevada em várias partes do mundo, sendo que no Brasil as Hb anormais S e C são as mais prevalentes.
Wanessa L. P. Vivas, Danilo S. Rebouças, Amaury L. D. Fabbro, Rosana Cipolotti   +3 more
doaj   +1 more source

Interação entre Hb C [beta6(A3)Glu>Lys] e IVS II-654 (C>T) beta-talassemia no Brasil Hb C [beta6(A3)Glu>Lys] and IVS II - 654 (C>T) beta thalassemia interaction in Brazil

Revista Brasileira de Hematologia e Hemoterapia, 2003
Thalassemias are a heterogeneous group of inherited disorders characterized by a microcytic hypochromic anemia and an imbalance in the synthesis of the globin-chains. Hb C is the second most frequently variant of hemoglobin found in Brazil.
Claudia R. Bonini-Domingos, Ana C. Bonini-Domingos, Ana R. Chinelato, Paula J. A. Zamaro, Patrícia H. O. Calderan   +4 more
doaj   +1 more source

Reaction trajectory revealed by a joint analysis of protein data bank. [PDF]

PLoS ONE, 2013
Structural motions along a reaction pathway hold the secret about how a biological macromolecule functions. If each static structure were considered as a snapshot of the protein molecule in action, a large collection of structures would constitute a ...
Zhong Ren
doaj   +1 more source

Studies on abnormal hemoglobins. V. The distribution of type S, sickle cell, hemoglobin and type F, alkali resistant, hemoglobin within the red cell population in sickle cell anemia.

Blood, 1951
1. When sufficiently concentrated sickle cell hemoglobin containing solutions are exposed to a constant stream of CO2 gas, the hemolysates gel. This gelling phenomenon is indicative of the presence of S hemoglobin and cannot be obtained with any other ...
Karl Singer, B. Fisher
semanticscholar   +1 more source

Hemoglobin stability: observations on the denaturation of normal and abnormal hemoglobins by oxidant dyes, heat, and alkali.

Journal of Clinical Investigation, 1970
Several unstable mutant hemoglobins have alterations which affect areas of the molecule involved in the attachment of heme to globin. Loss of heme from globin has been demonstrated during the denaturation of some of these unstable mutants. The importance
R. F. Rieder
semanticscholar   +1 more source

Studies of the incoporation of Fe59 into normal and abnormal hemoglobins.

Journal of Clinical Investigation, 1959
This study was undertaken to ascertain whether different normal and abnormal hemoglobin components exhibit different rates of Fe59 incorporation in human subjects and in experimental animals.
H. Ranney, P. Kono
semanticscholar   +1 more source

γA gene repeats polymorphism for the analysis of haplotypes of abnormal hemoglobins

Thalassemia Reports, 2014
Aim of this study was to analyze γ A gene repeat polymorphism for the analysis of haplotypes of hemoglobin (Hb) variants such as Hb S, Hb D-Punjab, Hb O-Arab. Sickle cell cases had mainly Benin and Arab/Indian haplotype.
Nejat Akar, Kadir Sipahi, Ece Akar, Erkan Yilmaz   +3 more
doaj   +1 more source

The first Chinese case of unstable Hemoglobin Santa Ana detected by capillary electrophoresis: a case report and literature review

Hematology, 2022
Hemoglobin Santa Ana [β88(F4)Leu→Pro (CTG > CCG) HBB: c.266T > C] is an unstable hemoglobin variant characterized by a substitution of the amino acid leucine by proline at the 88th position of the β-globin chain.
Li Du, Danqing Qin, Jicheng Wang, Cuize Yao, Juan Zhu, Hao Guo, Tenglong Yuan, Jie Liang, Aihua Yin   +8 more
doaj   +1 more source

Studies on several genetic hematologic traits of Mexicans IX. Abnormal hemoglobins and erythrocytic glucose-6-phosphate dehydrogenase deficiency in several Indian tribes.

Blood, 1966
The distribution of abnormal hemoglobins and erythrocytic glucose-6-phosphate dehydrogenase deficiency in 2000 Mexican Indians is described. It is pointed out that the frequency of hemoglobin S and G-6-PD deficiency is low and directly related to Negro ...
R. Lisker, G. Zárate, A. Loría
semanticscholar   +1 more source