Results 71 to 80 of about 1,088,189 (289)

Drug-induced acute pancreatitis

, 2015
The most common etiology for AP are gallstones and alcohol abuse. Other causes include iatrogenic injury (i.e. post-ERCP), metabolic and autoimmune disorders, inherited disorders, neoplasia (even intraductal papillary mucinous neoplasiaIPMN), anatomical ...
M. Bellocchi, P. Campagnola, L. Frulloni
semanticscholar   +1 more source

Drug induced lung disease--amiodarone in focus.

Medicinski pregled, 2014
More than 380 medications are known to cause pulmonary toxicity. Selected drugs that are important causes of pulmonary toxicity fall into the following classes: cytotoxic, cardiovascular, anti-inflammatory, antimicrobial, illicit drugs, miscellaneous ...
N. Vasic, B. Milenković, D. Pesut, R. Stević, D. Jovanovic   +4 more
semanticscholar   +1 more source

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
wiley   +1 more source

Smoke, alcohol and drug addiction and male fertility [PDF]

, 2018
In recent decades, the decline in human fertility has become increasingly more worrying: while therapeutic interventions might help, they are vexing for the couple and often burdened with high failure rates and costs.
DE ANGELIS, Cristina Concetta, Di Dato, Carla, Gianfrilli, Daniele, Isidori, Andrea, Menafra, Davide, Pivonello, Rosario, Pozza, Carlotta, Sansone, Andrea   +7 more
core   +1 more source

Fenfluramine, a serotonin‐releasing drug, prevents seizure‐induced respiratory arrest and is anticonvulsant in the DBA/1 mouse model of SUDEP

Epilepsia, 2019
Prevention of sudden unexpected death in epilepsy (SUDEP) is a critical goal for epilepsy therapy. The DBA/1 mouse model of SUDEP exhibits an elevated susceptibility to seizure‐induced death in response to electroconvulsive shock, hyperthermia ...
Srinivasan Tupal, C. Faingold
semanticscholar   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

Sperm abnormality toxicity due to cyclosporine A and the ameliorative effect of royal jelly in male rats

Journal of Basic and Applied Zoology, 2016
The immunosuppressive drug, utilized widely in Egypt, cyclosporine A was studied to evaluate its toxicity in male rats. Animals were divided into a control (untreated), 3 groups treated intraperitoneally with 20, 40 and 60 m/kg cyclosporine A for 5, 10 ...
Azza M. Gawish, Samya ElFiky, Mary Therase, Amira AbdElraaof, Wagdi Khalil, Karima A. Mohamed   +5 more
doaj   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

The Teratogenic Effects of Acetaminophen on the Mice Embryo

پزشکی بالینی ابن سینا, 2000
Acetaminophen is a  widely used  analegesis and antipyretic which is    considered  safe  at  therapeutic  levels . This  medicine is  also  a  kind  of    influensive substiution via the gut, it is metabolized in liver and  converted    to consistant 
Mahdi Jalali, Kazem Parivar, Mohammadreza Nikravesh, Mohammadreza Hossieni-Ravesh   +3 more
doaj  

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source