Results 91 to 100 of about 1,171,990 (253)

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

Laboratory tests in patients treated with isotretinoin: occurrence of liver and muscle abnormalities and failure of AST and ALT to predict liver abnormality. [PDF]

, 2017
Current laboratory monitoring may not be optimal. A retrospective chart review was performed on thelaboratory results of 246 patients who were treated with isotretinoin for acne over a 9-year period.
Grimes, Lorraine R., Webster, Guy F., Webster, Timothy G.   +2 more
core   +1 more source

Long‐term culture of skin biopsies: maintenance of fibroblast production and competency of reprogramming

FEBS Open Bio, EarlyView.
Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar, Michael A. Ripperger, Grant M. Westlake, Kevin C. Ess   +3 more
wiley   +1 more source

Human papillomavirus genotyping among the women with cervical abnormalities in Ulaanbaatar, Mongolia [PDF]

, 2019
学位記番号 ...
TSEDENBAL, BATCHIMEG, TSEDENBAL, BATCHIMEG, ツェデンバル, バトチメグ   +2 more
core  

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

Anatomical Abnormalities in Multiple Permanent Teeth [PDF]

Journal of Clinical and Diagnostic Research, 2015
Karthik Venkataraghavan, Vidhi Shah, Prashant Choudhary, Krishna Trivedi, Shalin Shah   +4 more
doaj   +1 more source

Analysis of Treacher Collins syndrome 4‐associated mutations in Schizosaccharomyces pombe

FEBS Open Bio, EarlyView.
Fission yeast models carrying Treacher Collins syndrome type 4‐associated mutations reveal that impaired processivity of RNA polymerase I leads to defective rRNA transcription. This study highlights the essential role of a conserved arginine residue in Pol I elongation and provides mechanistic insight into the pathogenesis of ribosomopathies.
Kei Kawakami, Hiroaki Kato
wiley   +1 more source

Flower-Like Plasma Cell Nuclei in Multiple Myeloma

Turkish Journal of Hematology, 2021
Abibatou Sall, Moussa Seck, Diama Samb, Blaise Félix Faye, Macoura Gadji, Saliou Diop, Awa Oumar Touré   +6 more
doaj   +1 more source

Optical genome mapping reveals complex cytogenetic abnormalities in multiple myeloma

Haematologica
Not available.
Jorge A. Palacios, Mónica Bernal, Jose R. Vílchez, Pilar Garrido, Pilar Jiménez, Juan F. Gutiérrez-Bautista, María C. Barrera-Aguilera, Lucía Ballesta, Teresa Rodríguez, María J. Olivares-Durán, Francisco Ruiz-Cabello   +10 more
doaj   +1 more source

Experience of the diagnosis and observation of a child with wolf-hirschhorn syndrome

Zdorovʹe Rebenka, 2017
Modern data about the causes, course peculiarities, principles of diagnosis and symptomatic treatment of Wolf-Hirshhorn syndrome are given in the article. The description of own clinical case is presented.
L.V. Besh, O.I. Matsyura, G.V. Bulak, V.N. Chyrun, V.P. Bobyk, D.V. Stakhnyak   +5 more
doaj   +1 more source